A5056004909- Congenital heart defects research
- Single-cell and spatial transcriptomics
- Pluripotent Stem Cells Research
- Genomics and Chromatin Dynamics
- Gene Regulatory Network Analysis
Brotman Baty Institute
2022-2024
Abstract The house mouse ( Mus musculus ) is an exceptional model system, combining genetic tractability with close evolutionary affinity to humans 1,2 . Mouse gestation lasts only 3 weeks, during which the genome orchestrates astonishing transformation of a single-cell zygote into free-living pup composed more than 500 million cells. Here, establish global framework for exploring mammalian development, we applied optimized combinatorial indexing profile transcriptional states 12.4 nuclei...
Abstract The house mouse, Mus musculus , is an exceptional model system, combining genetic tractability with close homology to human biology. Gestation in mouse development lasts just under three weeks, a period during which its genome orchestrates the astonishing transformation of single cell zygote into free-living pup composed >500 million cells. Towards global framework for exploring mammalian development, we applied combinatorial indexing (sci-*) profile transcriptional states 12.4...
Abstract Sex differences and age-related changes in the human heart at tissue, cell, molecular level have been well-documented many may be relevant for cardiovascular disease. However, how programs within individual cell types vary across individuals by age sex remains poorly characterized. To better understand this variation, we performed single-nucleus combinatorial indexing (sci) ATAC- RNA-Seq samples from nine donors. We identify hundreds of differentially expressed genes find epigenetic...
Abstract Sex differences and age-related changes in the human heart at tissue, cell, molecular level have been well-documented many may be relevant for cardiovascular disease. However, how programs within individual cell types vary across individuals by age sex remains poorly characterized. To better understand this variation, we performed single-nucleus combinatorial indexing (sci) ATAC- RNA-Seq samples from nine donors. We identify hundreds of differentially expressed genes sex. dependent...