A5025089247- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Colorectal and Anal Carcinomas
- Dermatological and Skeletal Disorders
- Hidradenitis Suppurativa and Treatments
- Autoimmune Bullous Skin Diseases
- Nonmelanoma Skin Cancer Studies
- NF-κB Signaling Pathways
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- TGF-β signaling in diseases
- Drug-Induced Ocular Toxicity
- Pituitary Gland Disorders and Treatments
- Skin Diseases and Diabetes
- Psoriasis: Treatment and Pathogenesis
- Cutaneous lymphoproliferative disorders research
- RNA regulation and disease
- Myasthenia Gravis and Thymoma
- PI3K/AKT/mTOR signaling in cancer
- Hereditary Neurological Disorders
- Protein Kinase Regulation and GTPase Signaling
Alfaisal University
2015-2025
King Faisal Specialist Hospital & Research Centre
2016-2025
AbbVie (United States)
2024
King Saud bin Abdulaziz University for Health Sciences
2018
University of Toronto
2012-2013
McGill University
2010-2012
McGill University Health Centre
2010-2011
Abstract Background Current treat‐to‐target recommendations for atopic dermatitis (AD) may not include high enough treatment targets and do fully consider patient needs. Objective To develop optimized AD management, including disease severity assessments, goals targets, guidance escalation/modification. Methods An international group of expert dermatologists drafted a series management using insights from global study 87 44 countries. Experts voted on modified eDelphi voting process. Results...
Abstract: Transforming growth factor (TGF)-β is an important cytokine that negatively regulates keratinocyte proliferation. Deregulation of TGF-β signalling has been reported in psoriasis, where despite increased expression TGF-β, psoriatic keratinocytes continue to hyperproliferate. Recently, we have identified CD109, a glycosyl phosphatidylinositol (GPI)-anchored protein, as novel co-receptor and negative regulator signalling. In the current work, demonstrate release CD109 from cell...
Abstract Inconsistent criteria are used to identify patients with atopic dermatitis (AD) who candidates for systemic therapy and assess their response therapy. This may lead undertreatment treatment dissatisfaction. A treat-to-target (T2T) framework was previously proposed guide decisions in moderate-to-severe AD.1 While patient representatives were included the T2T consensus voting process, no or caregiver stakeholders development of recommendations. Additionally, a recent analysis...
Psoriasis is a chronic inflammatory skin disorder with significant global burden, impacting patients both physically and psychologically. While its exact etiology remains unclear, genetic predisposition environmental triggers play key roles. Biologic therapies have revolutionized psoriasis management, offering targeted effective disease control. However, despite their proven benefits, these treatments remain underutilized, limiting optimal outcomes contributing to disparities in care. This...
Abstract The objective was to study a large, international, ethnically diverse population of patients with atopic dermatitis (AD) support the creation patient-centric recommendations for AD management. Qualitative data were generated from 45-min, 1:1 telephone interviews conducted across 15 countries in each patient’s native language. Interviews explored impact on patients’ lives, most important symptoms, treatment expectations, and decision-making. Participants also questioned their current...
Hereditary sensory autonomic neuropathy type IV (HSAN-IV) is a rare autosomal recessive disorder that usually begins in infancy and characterized by anhidrosis, insensitivity to noxious stimuli leading self-mutilating behavior, intellectual disability. HSAN-IV caused mutations the neurotrophic tyrosine kinase receptor 1 gene, NTRK1, encoding high-affinity of nerve growth factor (NGF) which maps chromosome 1q21-q22. Patients with lack all NGF-dependent neurons, primary afferents sympathetic...
Skin cancer is the most common worldwide; one in every three diagnosed malignancies a skin cancer. However, rarely reported Saudi Arabia so we conducted this study to highlight these underreported neoplasms.Determine prevalence and patterns of basal cell carcinoma (BCC) primary squamous (SCC), types nonmelanoma (NMSC) with respect age, sex, anatomic location identify potentially associated risk factors.Retrospective, descriptive medical record review.A tertiary care centre.We did...
Abstract Background Vitiligo is an autoimmune disease characterized by depigmented patches and macules. It associated with many diseases, the most common of which thyroid disease. The association between Interferon (IFN) therapy vitiligo rarely reported in literature, despite its usage hepatitis B viral infection, C infection (HCV), hematological malignancies melanoma. Case We are reporting eight cases that appeared after treating HCV IFN. Conclusion unmasks susceptible individuals.
Acute hemorrhagic edema of infancy (AHEI) is a rare type leuckocytoclastic vasculitis. It affects mainly children less than two years age. Many precipitating factors have been reported, including infectious etiology and vaccination. We are reporting two-year-old boy with AHEI after measles, mumps, rubella (MMR) vaccine. To our knowledge this the second reported case an MMR
Atopic dermatitis (AD) is a long-term, pruritic, recurrent, systemic, inflammatory skin disorder. In the Middle East region, burden of AD understudied, and there dearth guideline documents for practitioners.An expert panel meeting, encompassing 12 dermatologists from Kingdom Saudi Arabia (KSA), was congregated to develop evidence- experience-based consensus recommendations management, especially in adults KSA. They completed questionnaire with seven clinical statements, defined when...
Abstract Atopic dermatitis (AD) is a common, chronic inflammatory skin disease often associated with significant long-term burden. AD can profoundly impact patient’s physical and mental health. Current management recommendations do not capture patient perspectives on their treatment needs, expectations drivers of decision-making. Qualitative research needed to support the creation patient-centric for assessment management. To study large, international, ethnically diverse population patients...
Keratinocyte differentiation factor (KDF)1 has been shown to cause ectodermal dysplasia with or without hidradenitis suppurativa in a single family. KDF1 is known regulate epidermal through its interaction IκB kinase (IKK)α. We report novel de novo variant (p.His254Tyr) 20-year-old male patient presenting and dysplasia. demonstrate that variants associated actually pathogenic gain-of-function of upregulation IKKα. Ectodermal may be present subset individuals should investigated. Inhibition...
Pemphigus is a chronic potentially life-threatening autoimmune blistering disease affecting the skin and/or mucous membranes. Rituximab being increasingly used and found efficacious in treatment of pemphigus.To present Middle-Eastern experience with use rituximab pemphigus.A retrospective analysis patient files was conducted which revealed 23 patients pemphigus who were treated (either alone or IVIG) dermatology department tertiary care hospital from July 2004 to December 2014.The mean time...
Many dermatologic and systemic diseases have been reported in association with hidradenitis suppurativa, but its Down syndrome is rarely mentioned the literature. The objective of current study was to assess frequency suppurativa patients who visited our clinic over 4 years.We recorded presenting complaints problems from January 2011 December 2014. Medical photographs were taken. Patients assessed according severity treated topical medications.Twenty-nine new during this period. Eleven had...
Purpose: There is limited information about the diagnosis and treatment of hidradenitis suppurativa (HS) in Kingdom Saudi Arabia (KSA). This Delphi consensus study was conducted to develop recommendations for management HS KSA.Methods: The expert panel including 12 dermatologists with extensive experience treating patients provided nine statements on assessment, management, comorbidities multidisciplinary approach, education. experts also developed clinical questions pertaining rolled out as...
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder caused by defective DNA repair that results in extreme sensitivity to ultraviolet (UV) rays. Depending on the type of XP, disease may affect skin, eyes and nervous system.Describe dermatologic manifestations patients suffering from XP.Retrospective, descriptive review medical records.Dermatology clinic at tertiary care center Riyadh.This study included Saudi with clinically confirmed XP.Demographic clinical data including...
Abstract Background Autosomal recessive congenital ichthyosis ( ARCI ) is a rare disorder of keratinization. Infants (10–15%) born with this condition are encapsulated in hyperkeratotic membrane covering the entire body and called “collodion babies.” So far, mutations nine different genes have been identified as causative implicated pathogenesis clinically genetically heterogeneous group disorders. Among these, TGM 1 gene most commonly mutated . Methods We 11 patients from five...
D-penicillamine (DPA)-induced pseudo-pseudoxanthoma elasticum (PXE) and elastosis perforans serpiginosa (EPS) has been reported in the past, but most of treatment modalities used before have a sub.optimal response. We report case DPA-induced pseudo-PXE with extensive EPS who had an excellent rapid response to acitretin. To best our knowledge no such published even though there is single effectiveness isotretinoin serpiginosa. SIMILAR CASES PUBLISHED: One similar different medication (reference 13).
Autosomal recessive congenital ichthyosis (ARCI), is a rare form of with multiple mutations identified. Ichthyin (NIPAL4) gene mutation identified in about 18% cases. In addition to the usual phenotype we are presenting new association between ARCI and atopic diathesis allergies. To best our knowledge this second case report such an diathesis.