A5010351872- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Supramolecular Self-Assembly in Materials
- Genetics, Bioinformatics, and Biomedical Research
- Biomedical and Engineering Education
- Teaching and Learning Programming
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Chemical Synthesis and Analysis
University of Washington
2020-2022
Abstract Cyclic symmetry is frequent in protein and peptide homo‐oligomers, but extremely rare within a single chain, as it not compatible with free N‐ C‐termini. Here we describe the computational design of mixed‐chirality macrocycles rigid structures that feature internal cyclic symmetries or improper rotational inaccessible to natural proteins. Crystal three C2‐ C3‐symmetric macrocycles, six diverse S2‐symmetric match computationally‐designed models backbone heavy‐atom RMSD values 1 Å...
Despite remarkable advances in the assembly of highly structured coordination polymers and metal–organic frameworks, rational design such materials using more conformationally flexible organic ligands as peptides remains challenging. In an effort to make fully programmable, we first developed a computational method for generating metal-mediated 3D frameworks rigid symmetric peptide macrocycles with metal-coordinating sidechains. We solved structures six crystalline networks involving...
Undergraduate research experiences can improve student success in graduate education and STEM careers. During the COVID-19 pandemic, undergraduate researchers at our institution many others lost their work–study positions due to interruption of in-person activities. This imposed a financial burden on students eliminated an important learning opportunity. To address these challenges, we created paid, fully remote, cohort-based curriculum computational protein design. Our used existing design...
Abstract Undergraduate research experiences can improve student success in graduate education and STEM careers. During the COVID-19 pandemic, undergraduate researchers at our institution many others lost their work-study positions due to interruption of in-person activities. This imposed a financial burden on students eliminated an important learning opportunity. To address these challenges, we created paid, fully-remote, cohort-based curriculum computational protein design. Our used...