A5041711215- Plant biochemistry and biosynthesis
- Microbial Natural Products and Biosynthesis
- Carbohydrate Chemistry and Synthesis
- Steroid Chemistry and Biochemistry
- Chemical Synthesis and Analysis
- Microbial Metabolic Engineering and Bioproduction
- Genomics and Phylogenetic Studies
- Pharmacological Effects of Natural Compounds
- Biotin and Related Studies
- Click Chemistry and Applications
- Pharmacogenetics and Drug Metabolism
- Pesticide and Herbicide Environmental Studies
- Cholesterol and Lipid Metabolism
- Enzyme Catalysis and Immobilization
- Wastewater Treatment and Nitrogen Removal
- Microbial Metabolites in Food Biotechnology
Tottori University
2019-2023
RIKEN Center for Sustainable Resource Science
2021-2022
Enzymes catalyzing [4+2] cycloaddition have attracted increasing attention because of their key roles in natural product biosynthesis. Here, we solved the X-ray crystal structures a pair decalin synthases, Fsa2 and Phm7, that catalyze intramolecular cycloadditions to form enantiomeric scaffolds during biosynthesis HIV-1 integrase inhibitor equisetin its stereochemical opposite, phomasetin. Computational modeling, using molecular dynamics simulations as well quantum chemical calculations,...
Steroid hormones modulate numerous physiological processes in various higher organisms. Research on the physiology, biosynthesis, and metabolic degradation of steroid is crucial for developing drugs, agrochemicals, anthelmintics. Most hormone biosynthetic pathways, excluding those insects, have been elucidated, roles several cytochrome P450s (CYPs, P450s), heme (iron protoporphyrin IX)-containing monooxygenases, identified. Specifically, animal pathways their three dimensional structures...
Ladderane lipids (found in the membranes of anaerobic ammonium-oxidizing [anammox] bacteria) have unique ladder-like hydrophobic groups, and their highly strained exotic structure has attracted attention scientists. Although enzymes encoded type II fatty acid biosynthesis (FASII) gene clusters anammox bacteria, such as S-adenosyl-l-methionine (SAM)-dependent enzymes, been proposed to construct a using substrate connected acyl carrier protein from bacteria (AmxACP), no experimental evidence...
Abstract Enzymes catalyzing [4+2] cycloaddition have attracted increasing attention because of their key roles in natural product biosynthesis. Here, we solved the X‐ray crystal structures a pair decalin synthases, Fsa2 and Phm7, that catalyze intramolecular cycloadditions to form enantiomeric scaffolds during biosynthesis HIV‐1 integrase inhibitor equisetin its stereochemical opposite, phomasetin. Computational modeling, using molecular dynamics simulations as well quantum chemical...
Summary Molecular chirality, discovered by Louis Pasteur in the middle of 19th century 1 , is found most primary and secondary metabolites. Particularly, so-called natural products are rich chiral centres 2 . The stereochemistry strictly recognized living organisms, thus closely related to their biological functions. Diels–Alder (DA) reaction, which forms a six-membered ring with up four centres, fundamental practical reaction for C–C bond formation synthetic chemistry 3 Nature has also...
Bindung einer linksdrehenden oder rechtsdrehenden Faltung mit Flip: Eine lineare Kohlenwasserstoffkette, die ein Dien und Dienophil enthält, wird gefaltet durch intramolekulare [4+2]-Cycloaddition in Dekalingrundgerüst umgewandelt. Die Substrate falten entgegengesetzt, binden aber der gleichen Ausrichtung Taschen eines Paares von Diels-Alderasen, um Dekalingerüste enantiomeren Konformationen zu liefern, wie Naoki Kato, Shunji Takahashi Shingo Nagano im Forschungsartikel auf S. 22575 berichten.