A5040022001- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Influenza Virus Research Studies
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Cancer, Lipids, and Metabolism
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- Nicotinic Acetylcholine Receptors Study
- CAR-T cell therapy research
- Click Chemistry and Applications
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Cancer Cells and Metastasis
- Chemical Synthesis and Analysis
Secretaría de Salud de Jalisco
2025
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco
2025
AstraZeneca (United States)
2022
TRIA Bioscience (United States)
2014-2019
Seattle University
2019
Bristol-Myers Squibb (Germany)
2013
Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, there remains a need for more prevention and treatment options individuals remaining at risk disease 2019 (COVID-19). Monoclonal antibodies (mAbs) against viral spike protein have potential to both prevent treat COVID-19 reduce death. Here, we describe AZD7442, combination two mAbs, AZD8895 (tixagevimab) AZD1061 (cilgavimab), that simultaneously bind distinct, nonoverlapping epitopes on receptor...
Immune response, inflammation, and lipid metabolism have important effects on cancer development progression. Several proteins in tumoral cells and/or tumor microenvironment are involved any of these processes, whereas some them participate all three, such as the zinc finger E-box-binding homeobox 1 (ZEB1) protein. This protein has been proposed to an role invasion metastasis cells, well be malignant transformation resistance treatments. So, this study, we present participation ZEB1 immune,...
The ongoing threat from Influenza necessitates the development of new vaccine and adjuvant technologies that can maximize immunogenicity, shorten production cycles, increase global supply. Currently, most successful adjuvants for vaccines are squalene-based oil-in-water emulsions. These enhance seroprotective antibody titers to homologous heterologous strains virus, augment a significant dose sparing activity could improve manufacturing capacity. As an alternative emulsion, we tested simple...
Nanoparticle-based delivery systems are being used to simplify and accelerate new vaccine development. Previously, we described the solid-phase synthesis of a 61-amino acid conjugate carrier comprising α-helical domain followed by two universal T cell epitopes. Circular dichroism, analytical centrifugation, dynamic light scattering indicate that this forms coiled-coil nanoparticles. Here expand potential appending B epitopes its amino sequence, thereby eliminating need for traditional...
Rituximab, a monoclonal antibody targeting CD20 on B cells, is currently used to treat many subtypes of cell lymphomas. However, treatment not curative and response rates are variable. Recombinant interleukin-21 (rIL-21) cytokine that enhances immune effector function affects both primary transformed differentiation. We hypothesized the combination rIL-21 plus rituximab would be more efficacious for malignancies than alone. cultured human cynomolgus monkey NK cells with found their activity...
Clinical outcomes of anti-nicotine vaccines may be improved through enhancements in serum antibody affinity and concentration. Two strategies were explored to improve vaccine efficacy outbred mice: the use enantiopure haptens formulation a bivalent vaccine. Vaccines incorporating natural (-) nicotine relative affinities >10-fold over (+) haptens, stimulated two-fold boost binding capacity, following injection with 3 cigarette equivalents nicotine, prevented larger proportion (>85%) from...
TACI-Ig is a soluble glycoprotein comprised of human IgG1-Fc fused with the extracellular domain TACI receptor. Chronic exposure to associated reduced circulating B cells in mouse and non-human primates, concomitant decrease immunoglobulin. Because these activities, clinical evaluation for treatment various autoimmune diseases cell malignancies. In this study, effect on ability C57Bl/6 mice clear influenza virus was evaluated. were exposed vehicle (negative control), dexamethasone (positive...
The rapid rate of influenza virus mutation drives the emergence new strains that inflict serious seasonal epidemics and less frequent, but more deadly, pandemics. While vaccination provides best protection against influenza, its utility is often diminished by unpredictability pathogenic strains. Consequently, efforts are underway to identify antiviral drugs monoclonal antibodies can be used treat recently infected individuals prevent disease in vulnerable populations. Next Generation...