A5002500234- Autoimmune Bullous Skin Diseases
- Skin and Cellular Biology Research
- Cutaneous Melanoma Detection and Management
- Urticaria and Related Conditions
- Hair Growth and Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders
- Nonmelanoma Skin Cancer Studies
- Hedgehog Signaling Pathway Studies
- Dermatology and Skin Diseases
- Nail Diseases and Treatments
- melanin and skin pigmentation
- Skin Protection and Aging
- Vascular Malformations and Hemangiomas
- Contact Dermatitis and Allergies
- Mast cells and histamine
- Vascular Tumors and Angiosarcomas
- Allergic Rhinitis and Sensitization
- Oral Health Pathology and Treatment
- Soft tissue tumors and treatment
- Antimicrobial agents and applications
- Silk-based biomaterials and applications
Iuliu Hațieganu University of Medicine and Pharmacy
2015-2025
Spitalul Clinic CF Cluj-Napoca
2022
Factors associated with survival in pemphigus have not yet been thoroughly addressed. Therefore, the present study, risk factors for overall mortality a large group of patients vulgaris and foliaceus were investigated. A retrospective hospital-based cohort study was carried out, between October 1998 November 2012, Department Dermatology University Medicine Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania. The investigated prognostic endpoint patients. total 130 studied (108 22 foliaceus). In...
Importance Kindler epidermolysis bullosa is a genetic skin-blistering disease associated with recessive inherited pathogenic variants in FERMT1 , which encodes kindlin-1. Severe orofacial manifestations of bullosa, including early oral squamous cell carcinoma, have been reported. Objective To determine whether hypoplastic pitted amelogenesis imperfecta feature bullosa. Design, Settings, and Participants This longitudinal, 2-center cohort study was performed from 2003 to 2023 at the...
Background/Objectives: Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, with diverse clinical presentations. This study aims to correlate findings from dermoscopy, ultrasonography, ex vivo confocal microscopy, and histology improve diagnostic accuracy guide better management of cSCC. Methods: cross-sectional study, conducted between July 2022 December 2024, included 26 patients 35 clinically suspicious cSCC tumors, analyzed through clinical, dermoscopic,...
Mucous membrane pemphigoid is a group of chronic subepithelial autoimmune blistering diseases that mainly affect mucous membranes. Laminin 332-specific autoantibodies are present in approximately 1/3 the patients, being associated with an increased risk malignancy. Because severe complications, early recognition disease allowing timely therapy essential. The gold standard methods for detection laminin autoantibodies, including immunoprecipitation and immunoblotting non-quantitative,...
Background: Oral cancer is highly aggressive due to difficult diagnosis, therapy resistance and increasing frequency; thus finding prevention therapies very important. Aim: This study evaluates the use of gold silver nanoparticles (NPs), phyto-synthesized with Cornus mas extract against oral dysplastic lesions. Methods: NPs were characterized by UV-Vis, Fourier-transform infrared spectroscopy, transmission electron microscopy, x-ray diffraction laser Doppler microelectrophoresis. Biological...
Abstract Background Epidermolysis bullosa ( EB ) is a rare and so far incurable genetic disease, affecting mainly the skin mucosal membranes, manifesting with blisters triggered by minor mechanical trauma. Since only few epidemiological data on are available, we established Registry for implemented molecular diagnostic methods. Objective We present epidemiologic from genotype–phenotype correlations. Methods In 2006, registry of patients was initiated in Department Dermatology University...
(1) Background: the aim of study was to demonstrate its usefulness in field imaging evaluation plaque morphology psoriasis vulgaris, with an emphasis on use confocal microscopy and other advanced skin-imaging techniques. (2) Methods: we conducted a prospective over two years (July 2022–April 2024), patients diagnosed moderate or severe treated dermatology department our institution. We selected 30 patients, whom 15 became eligible according inclusion exclusion criteria. A total 60 plaques...
Background/Objectives: Epidermolysis bullosa (EB) is a hereditary condition characterized by skin and mucosal fragility, with various degrees of severity. This study’s objectives are to obtain updated epidemiological data that will help identify the specific types subtypes EB, determine case distribution in Romania, establish incidence prevalence condition. Methods: population-based observational study included Romanian patients collected from 2012 2024. The following information was...
Summary Background and objectives Incontinentia pigmenti is a rare X‐linked dominantly inherited systemic disease affecting primarily the skin but also other neuroectodermal tissues such as teeth, hair, eyes, central nervous system. Patients methods This multicenter case series study was conducted at three European departments of Dermatology including 30 patients with incontinentia pigmenti. Twenty were evaluated clinically genetically, another ten only genetically. Results The included 28...
Severe, extensive, therapy resistant alopecia areata represents a clinical challenge. Systemic corticosteroids are therapeutic tool that still needs to be evaluated.The purpose of this study was assess the efficacy and safety methylprednisolone pulse in find prognostic factors for favourable outcome.A total 32 patients with severe multifocal (more than 40% scalp hair loss), totalis, universalis were treated infusions 500 mg 3 days every month consecutive months. The end point 12 months.Of...
Cutaneous squamous cell carcinoma, a type of non-melanoma skin cancer, is form keratinocyte carcinoma that stands as one the most prevalent cancers, exhibiting rising frequency. This review provides an overview latest literature on imaging methods for diagnosing (SCC) and actinic keratosis (AK). It discusses diagnostic criteria, advantages, disadvantages various techniques such dermatoscopy, ultrasound (US), in vivo ex-vivo reflectance confocal microscopy (RCM), line-field optical coherence...
In contrast to Western Europe, in Central and Eastern Europe reports show higher rates of advanced melanoma lower survival. Our aim was document compare risk factors skin health behaviour patients diagnosed with people not affected by this disease a large medical university centre from Romania (Cluj-Napoca). Two hundred forty-seven followed-up the Department Dermatology at Cluj-Napoca Emergency County Hospital 956 completed paper-based questionnaire regarding factors, self-protecting...
(1) Background: Photodynamic therapy (PDT) involves the selective killing of tumor cells by generation reactive oxygen species using a photosensitizer (PS) activated irradiation. In melanoma, PDT efficiency is altered several mechanisms, such as presence melanin and melanosomes pro-survival pathways mediated transcription factors as: AP-1 (activator protein), MITF (microphthalmia inducible factor), HIF1α (hypoxia NF-kB (nuclear factor kappa B). The study aimed to investigate anti-melanoma...
(1) Background: The aim of this study was to correlate the diagnostic criteria described in dermatoscopy, ultrasonography (US), ex vivo confocal microscopy, and histology most common subtypes basal cell carcinoma (BCC). (2) Methods: We conducted a prospective including 46 BCC cases, which were analyzed with dermatoscopy using Delta 30 dermatoscope Vidix 4.0 videodermoscope, US high-resolution 20 MHz linear probe, along histopathological analysis. (3) Results: This categorized by histological...
Progesterone hypersensitivity or autoimmune progesterone dermatitis is characterized by heterogeneous skin eruptions that cyclically aggravate during the second half of menstrual cycle, corresponding to a rise in level. Clinical presentation highly variable and includes all urticaria manifestations with without angioedema, vesiculobullous, eczematous, purpuric target‑like lesions on mucous membrane. Both endogenous as well exogenous progestogens may represent an initial trigger. We report...