A5077972812- Cardiac and Coronary Surgery Techniques
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Schizophrenia research and treatment
- Statistical Methods in Clinical Trials
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Meta-analysis and systematic reviews
- Organ Transplantation Techniques and Outcomes
- Treatment of Major Depression
- Coronary Interventions and Diagnostics
- Healthcare Policy and Management
- Pharmaceutical studies and practices
- Organ Donation and Transplantation
- Ethics in Clinical Research
- Cardiac Health and Mental Health
- Genetic Associations and Epidemiology
- Intraocular Surgery and Lenses
- Ophthalmology and Visual Impairment Studies
- Primary Care and Health Outcomes
UCLouvain Saint-Louis Brussels
2024
Robert Gordon University
2023
Program Support Center
2010-2022
Perry Point VA Medical Center
2008-2022
University of Maryland, Baltimore
2003-2018
The Coordinating Center
1989-2018
VA West Los Angeles Medical Center
2017
VA Greater Los Angeles Healthcare System
2017
VA Eastern Colorado Health Care System
2012-2015
University of Colorado Anschutz Medical Campus
2015
• We investigated the effectiveness of two brief psychotherapies, interpersonal psychotherapy and cognitive behavior therapy, for treatment outpatients with major depressive disorder diagnosed by Research Diagnostic Criteria. Two hundred fifty patients were randomly assigned to one four 16-week conditions: psychotherapy, imipramine hydrochloride plus clinical management (as a standard reference treatment), placebo management. Patients in all treatments showed signifi-cant reduction symptoms...
Although generalized convulsive status epilepticus is a life-threatening emergency, the best initial drug treatment uncertain. We conducted five-year randomized, double-blind, multicenter trial of four intravenous regimens: diazepam (0.15 mg per kilogram body weight) followed by phenytoin (18 kilogram), lorazepam (0.1 phenobarbital (15 and kilogram). Patients were classified as having either overt (defined easily visible convulsions) or subtle (indicated coma ictal discharges on...
We conducted a 10-center, double-blind trial to compare the efficacy and toxicity of four antiepileptic drugs in treatment partial secondarily generalized tonic-clonic seizures 622 adults. Patients were randomly assigned with carbamazepine, phenobarbital, phenytoin, or primidone followed for two years until drug failed control caused unacceptable side effects. Overall success was highest carbamazepine intermediate lowest (P less than 0.002). Differences failure rates explained primarily by...
Coronary-artery bypass grafting (CABG) has traditionally been performed with the use of cardiopulmonary (on-pump CABG). CABG without (off-pump CABG) might reduce number complications related to heart-lung machine.We randomly assigned 2203 patients scheduled for urgent or elective either on-pump off-pump procedures. The primary short-term end point was a composite death (reoperation, new mechanical support, cardiac arrest, coma, stroke, renal failure) before discharge within 30 days after...
Valproate is approved for use primarily in patients with absence seizures, but the drug has a broad spectrum of activity against seizures all types. Partial or secondarily generalized tonic—clonic are often difficult to control adequately standard treatment, usually carbamazepine phenytoin.
Office-based treatment of opiate addiction with a sublingual-tablet formulation buprenorphine and naloxone has been proposed, but its efficacy safety have not well studied.We conducted multicenter, randomized, placebo-controlled trial involving 326 opiate-addicted persons who were assigned to office-based sublingual tablets consisting (16 mg) in combination (4 mg), alone or placebo given daily for four weeks. The primary outcome measures the percentage urine samples negative opiates...
• We studied the course of depressive symptoms during an 18-month naturalistic follow-up period for outpatients with Major Depressive Disorder treated in National Institute Mental Health Treatment Depression Collaborative Research Program. The treatment phase consisted 16 weeks randomly assigned following: cognitive behavior therapy, interpersonal imipramine hydrochloride plus clinical management (CM), or placebo CM. Follow-up assessments were conducted at 6,12, and 18 months after...
<b>Objective: </b> To determine the relative tolerability and efficacy of two newer antiepileptic drugs, lamotrigine (LTG) gabapentin (GBP), as compared to carbamazepine (CBZ) in older patients with epilepsy. <b>Methods: This was an 18-center, randomized, double-blind, double dummy, parallel study 593 elderly subjects newly diagnosed seizures. Patients were randomly assigned one three treatment groups: GBP 1,500 mg/day, LTG 150 CBZ 600 mg/day. The primary outcome measure retention trial for...
To evaluate the safety and efficacy of an 8 mg/day sublingual dose buprenorphine in maintenance treatment heroin addicts by comparison with a 1 over 16-week period. As secondary objective, outcomes were determined concurrently for patients treated two other levels.Patients randomized to four dosage groups double-blind.Twelve outpatient opiate centers throughout United States.Two hundred thirty-nine women 497 men who met DSM-III-R criteria opioid dependence seeking treatment.Patients received...
Background— Chronic heart failure remains a major cause of mortality and morbidity. The role antithrombotic therapy in patients with chronic has long been debated. objective this study was to determine the optimal agent for reduced ejection fractions who are sinus rhythm. Methods Results— This prospective, randomized clinical trial open-label warfarin (target international normalized ratio 2.5 3.0) double-blind treatment either aspirin (162 mg once daily) or clopidogrel (75 had 30-month...
Coronary-artery bypass grafting (CABG) surgery may be performed either with cardiopulmonary (on pump) or without (off pump). We report the 5-year clinical outcomes in patients who had been included Veterans Affairs trial of on-pump versus off-pump CABG.From February 2002 through June 2007, we randomly assigned 2203 at 18 medical centers to undergo CABG, 1-year assessments completed by May 2008. The two primary were death from any cause and a composite outcome major adverse cardiovascular...
Background— The Department of Veterans Affairs Randomized On/Off Bypass (ROOBY) trial compared clinical and angiographic outcomes in off-pump versus on-pump coronary artery bypass graft (CABG) surgery to ascertain the relative efficacy 2 techniques. Methods Results— From February 2002 May 2007, ROOBY randomized 2203 patients CABG. Follow-up angiography was obtained 685 (62%) patients. Angiograms were analyzed (blinded treatment) for FitzGibbon classification (A=widely patent, B=flow limited,...
Summary: : In 1985 a 5‐year multicenter Veterans Administration Cooperative Study was completed that compared the efficacy and toxicity of phenobarbital, carbamazepine, phenytoin, primidone in double‐blind prospective study design. A total 622 patients, either previously untreated or undertreated, were entered into study. Strict exclusion criteria limited confounding factors such as drug alcohol abuse. Results showed each four drugs used monotherapy similarly effective treatment generalized...
INTRODUCTION: Telemedicine has shown promise in inflammatory bowel disease (IBD). The objective of this study was to compare activity and quality life (QoL) a 1-year randomized trial IBD patients receiving telemedicine vs. standard care. METHODS: Patients with worsening symptoms the prior 2 years were eligible for randomization (monitoring via texts EOW or weekly) primary outcomes differences change QoL between groups; healthcare utilization among groups secondary aim. RESULTS: 348...
In Brief Background Hormonal therapy to the brain-dead potential organ donor can include thyroid hormone (triiodothyronine [T3] or levothyroxine [T4]), corticosteroids, antidiuretic hormone, and insulin. Methods Data on 66,629 donors (2000–2009) were retrospectively reviewed. Documentation T3/T4 was available in 63,593 (study 1), but 23,469 had incomplete documentation of other hormones. 40,124, details all four hormones recorded 2). this cohort, group A (received T3/T4) consisted 23,022, B...
The long-term benefits of off-pump ("beating heart") vs on-pump coronary artery bypass grafting (CABG) remain controversial.To evaluate the 10-year outcomes and costs CABG in Department Veterans Affairs (VA) Randomized On/Off Bypass (ROOBY) trial.From February 27, 2002, to May 7, 2007, 2203 veterans ROOBY trial were randomly assigned or procedures at 18 participating VA medical centers. Per protocol, observed for 10 years; 10-year, post-CABG clinical assessed via centralized abstraction...
The design of clinical trials antiepileptic drugs should include explicit methods for numeric quantification seizures and side effects. Rating scales were developed to assess frequency severity (partial generalized tonic-clonic), systemic toxicity, neurotoxicity. These are combined form a single composite rating that reflects the overall effect drug on patient. system can be adapted compare efficacy toxicity any drugs, types seizures.
<b>Background: </b> Two prospective observations of adults with symptomatic, localization-related (partial) epilepsy included 1,102 patients in VA multicenter studies (VA-118 and VA-264). Analyses assessed the likelihood remaining seizure free for 12 24 months after initiating adequate antiepileptic drug therapy. Methods: Patients were grouped as having only secondarily generalized tonic-clonic seizures (GTC), complex partial (CPS), or both types (MIXED) at entry. The cumulative proportion...
Summary: Using neuropsychological testing procedures, we measured the behavioral characteristics of patients with epilepsy unaffected by anticonvulsant drugs and compared these results control subjects matched for age, sex, education. In a nationwide VA Cooperative study, 622 well‐defined seizure types were given selected battery tests prior to at 1 month after initiation drug therapy. Seventy‐four administered same test under standardized conditions centers. All controls also repeated...
Background: Despite advances in developing medications to treat alcohol dependence, few such have been approved by the Food and Drug Administration. Identified molecular targets are encouraging can lead development testing of new compounds. Atypical antipsychotic explored with varying results. Prior research suggests that quetiapine may be beneficial an alcohol‐dependent population very heavy drinkers. Methods: In this double‐blind, placebo‐controlled trial, 224 patients who reported...