A5005148314- Enzyme Structure and Function
- Amino Acid Enzymes and Metabolism
- Diet, Metabolism, and Disease
- Neurotransmitter Receptor Influence on Behavior
- Parkinson's Disease Mechanisms and Treatments
- Advanced Glycation End Products research
- Alcoholism and Thiamine Deficiency
- Spatial Neglect and Hemispheric Dysfunction
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Child Development and Digital Technology
- Protein Structure and Dynamics
- Fuzzy and Soft Set Theory
- Adipose Tissue and Metabolism
- Genomics and Phylogenetic Studies
- Cognitive and developmental aspects of mathematical skills
- Dementia and Cognitive Impairment Research
- Hemispheric Asymmetry in Neuroscience
- Folate and B Vitamins Research
- Advanced Neuroimaging Techniques and Applications
- Cannabis and Cannabinoid Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Biochemical Analysis and Sensing Techniques
- Glycosylation and Glycoproteins Research
- Neural and Behavioral Psychology Studies
- Advanced Algebra and Logic
Incheon Medical Center
2008-2022
Yonsei University
2021
Catholic University of Korea
2011
Kangbuk Samsung Hospital
2011
Sungkyunkwan University
2011
Seoul St. Mary's Hospital
2011
Korea National Institute of Health
2011
Ministry of Health and Welfare
2011
Bucheon St. Mary's Hospital
2011
Korea Advanced Institute of Science and Technology
2000-2004
Industrial production of antibiotics, such as semisynthetic penicillins and cephalosporins, requires optically pure d-p-hydroxylphenylglycine its derivatives important side-chain precursors. To produce d-amino acids, microbial d-hydantoinase (E.C. 3.5.2.2) is used for stereospecific hydrolysis chemically synthesized cyclic hydantoins. We report the apo-crystal structure from B. stearothermophilus SD1 at 3.0 Å resolution. The has a classic TIM barrel fold. Despite an undetectable similarity...
There is compelling evidence that alcohol-induced neurotoxicity related to glutamate excitotoxicity. It was hypothesized the low-affinity NMDA receptor antagonist memantine would improve cognitive function of patients with alcoholic dementia. The aim this study test hypothesis and evaluate effect on improvement alcohol-related dementia (ARD). designed as a 12-wk open-label investigating efficacy 20 mg memantine, antagonist, treatment for behavioural problems in 19 probable ARD according...
The primary aim of this study was to investigate the genetic predisposition Internet gaming disorder (IGD), and secondary compare results those alcohol dependence (AD). Two independent case-control studies were conducted. A total 30 male participants with IGD, diagnosed according 5th edition Diagnostic Statistical Manual Mental Disorders (DSM-5) criteria, sex-matched controls participated in 1. We designed targeted exome sequencing (TES) test for 72 candidate genes that have been implicated...
We previously proposed that the stereochemistry gate loops (SGLs) constituting substrate binding pocket of d-hydantoinase, a (β/α)8-barrel enzyme, might be major structural determinants specificity [Cheon, Y. H., et al. (2002) Biochemistry 41, 9410−9417]. To construct mutant d-hydantoinase with favorable for synthesis commercially important non-natural amino acids, SGL enzyme were rationally manipulated on basis analysis and sequence alignment three hydantoinases distinct specificities. In...
The purpose of this study was to investigate regional cerebral blood flow (rCBF) changes using 1110 MBq Tc-99m ECD SPECT in alcohol-related dementia (ARD) patients. Twenty-five patients with ARD and 22 healthy control subjects were included the study. Mini-Mental Status Examination applied controls. showed drastically reduced rCBF frontal cortices, basal ganglia, thalami. results indicate that is associated hypoperfusion both cortical subcortical regions. These findings support previous...
There have been lots of studies about the relationship between chronic use alcohol and development type 2 diabetes mellitus (T2DM). Chronic can be affected by altered level ghrelin leptin which regulate food-seeking behavior having similar mechanism controlling alcohol-craving behavior. Those peptides are known to correlated with T2DM. Ghrelin also regarded as possible regulators glucose metabolism insulin function. Hence, there is possibility that related deteriorated pathophysiology T2DM...
Hye-Rim Hwang, MD, Jung-Ah Min, Min Kwon, MS, Young-Hoon Cheon, Jae-Woo Park, MA, Sook-Hee Chai, PhD and Dai-Jin Kim, Department of Psychiatry, The Catholic University Korea College Medicine, Seoul, Addiction Clinic, Seoul St. Mary’s Hospital, Korea, Incheon Chamsarang Incheon, Psychology, Social Science, Bucheon, Rehabilitation with Welfare, Eulji Seongnam,
A variety of different methods to generate diverse proteins, including random mutagenesis and recombination, are currently available most them accumulate the mutations on target gene a protein, whose sequence space remains unchanged. On other hand, pool genes, which is generated by insertions, deletions exchange homologous domains with lengths in gene, would present protein lineages resulting new fitness landscapes. Here we report method variants spaces employing green fluorescent (GFP) as...
Abstract Background The adolescent brain may be susceptible to the influences of illicit drug use. While compensatory network reorganization is a unique developmental characteristic that restore several disorders, its association with methamphetamine (MA) use-induced damage during adolescence unclear. Methods Using independent component (IC) analysis on structural magnetic resonance imaging data, spatially ICs described as morphometric networks were extracted examine effects MA use gray...