Two new sesquiterpene coumarins, designated 5'-acetoxy-8'-hydroxyumbelliprenin (1) and 10'R-acetoxy-11'-hydroxyumbelliprenin (2), a diterpene, 15-hydroxy-6-en-dehydroabietic acid (3), along with 27 known compounds, were isolated from CHCl(3)-soluble extract of Ferula assa-foetida through bioassay-guided fractionation. The structures the metabolites 1-3 identified by spectroscopic data interpretation Mosher ester method. Compounds 4 6-13 showed greater potency against influenza A virus...

Chemical studies on the plants of genus Ferula (Apiaceae) show presence many compounds belonging mainly to groups monoterpene coumarins, sesquiterpene sesquiterpenes, furanocoumarins and aromatic compounds. Biological reveal significant activities, such as an anti-HIV activity, inhibition cytokine release early events carcinogenesis. Extracts some species have long been used in folk medicine for treating various diseases, possess antimicrobial estrogenic actions, are natural plant growth...

Five known furofuran lignans, dia-sesamin (1), 5-methoxysesamin (2), epi-magnolin (3), kobusin (4) and yangambin (5) were isolated for the first-time from oleo-gum resin of Commiphora wightii. This is first report on 13C NMR assignments (3). Each compounds was evaluated its ability to inhibit MIA PaCa-2 pancreatic cancer cell line. Among them, (3) displayed potential activity (IC50 = 29 nM) compared colchicine 56 nM). 3D-flexible alignment revealed that has great matching with tubulin...

To identify antimicrobial leads for medical applications, metabolites from the aerial part of Artemisia herba-alba were extracted and chromatographically purified. Two new sesquiterpenes, 1β,8α-dihydroxyeudesm-4-en-6β,7α,11βH-12,6-olide (1) 1β,6α,8α-trihydroxy, 11α-methyl-eudesma-4(15)-en-13-propanoate (2) along with a known eudesmanolide 11-epi-artapshin (3) identified. Structures determined by spectroscopic methods including 1D- 2D-NMR as well mass spectroscopy. Compound 3 inhibited...

Due to the various hazards of using synthetic chemical compounds in pharmaceutics, agriculture, and industry, scientists researchers do their best explore assess new green natural from resources with potent activity. The essential oil (EO) resin collected Araucaria heterophylla Salisb. was extracted by microwave technique chemically characterized via GC-MS analysis. Furthermore, extract EO assessed for its antioxidant phytotoxic activities. has 33 compounds, mainly terpenes (98.23%), major...

Abstract A thorough investigation of the ethyl acetate soluble fraction from a methanol extract resin Ferula foetida has resulted in isolation new sesquiterpene coumarin namely epi ‐conferdione ( 1 ), along with four known compounds, colladonin 2 karatavicinol 3 8‐acetoxy‐5‐hydroxyumbelliprenin 4 and asacoumarin 5 ). These structures were elucidated on basis extensive spectroscopic techniques, including 1D 2D NMR spectroscopy. The absolute configuration compound was established by circular...

Six new xenicane-type diterpenoids, designated as asterolaurins A-F (1-6), have been isolated from the organic extract of soft coral Asterospicularia laurae, collected in southern Taiwan. Compounds 1-4 possess a xenicin skeleton with 2-oxabicyclo[7.4.0]tridecane ring system, while 5 and 6 are xeniolide A-type compounds. The structures secondary metabolites, including their configurations, were established on basis an extensive spectroscopic analysis, 1D 2D NMR (1H-1H COSY, HMQC, HMBC,...

Phytochemical characterisation of the polar fraction Erigeron annuus extract led to isolation glycerylerigeroside (1), a unique γ-pyrone derivative. Structure 1 was decided by intensive study NMR and mass spectra as 3-O-[4'-((1,3-dihydroxypropan-2-yl)oxy)-β-D-glucopyranoside)]-4H-pyran-4-one, with uncommon glyceroxy side chain attached 4' position pyromeconic acid β-D-glucopyranoside. Antimicrobial potential tested against Staphylococcus aureus, Salmonella enterica, Candida albicans....

A new glucose derivative (1) and 2-C-methyl-d-erythritol (2) were isolated from the leaves of Ferula sinaica. The two structures elucidated by highfield NMR spectroscopy, that 1 was confirmed X-ray diffraction analysis.

Re-investigation of the chloroform extract aerial part Tephrosia apollinea afforded seven new 8-prenylated flavonoids namely tephroapollin A-G (1-7).The structures were established by spectroscopic methods, including HR-CI-MS, 1 H, 13 C, DEPT, HMQC, HMBC and ROESY experiments.The relative configuration analysis stereocenters for 5-7 was carried out on basis reported J-based method.General toxicity isolated compounds determined brine shrimp lethality bioassay.

A new caffeic acid cinnamyl ester (1) was isolated from the n-hexane-soluble fraction of an MeOH extract gum resin Ferula assa-foetida L. The structure determined to be (2E)-3,4-dimethoxycinnamyl-3-(3,4 diacetoxyphenyl) acrylate on basis spectroscopic data including 1D- and 2D-NMR. Compound 1 showed moderate activity for inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.7 cells, with IC50 value 54.9 microm.

Abstract Four new diterpenes, cespihypotins W–Z ( 1 – 4 ), having the verticillane skeleton and characterized by an α , β ‐unsaturated γ ‐hydroxycyclopentanone moiety, a eudesmanolide‐type sesquiterpene, cespilactam A 5 containing ‐lactam residue, were isolated from AcOEt‐soluble fraction of Taiwanese soft coral Cespitularia hypotentaculata. The structure relative configuration these metabolites was elucidated through extensive interpretation MS, COSY, HSQC, HMBC, NOESY experiments...

Since ancient times, the three Salvia L. species: aegyptiaca L., lanigera Poir., and multicaulis Vahl, have been utilised in traditional medicine all across world. These species are now subjected to in-depth chemical pharmacological investigations order find physiologically active chemicals. In present study, essential oil composition biological activity of these were studied. Using various extraction methods: hydrodistillation (HD) microwave-assisted (MAHD) compare efficiency, volatile...

Abstract Five new diterpenes, cespihypotins W–Z ( 1 – 4 , resp.) and cespihypotone 5 ) have been isolated from the AcOEt‐soluble fraction of Formosan soft coral Cespitularia hypotentaculata. Two them having norverticillane skeleton, i.e. 2 other three, 3 possessing a verticillane skeleton. The structures were established as (+)‐(1 β H,7 E )‐6 ,11 ‐dihydroxynorverticilla‐4(18),7‐diene‐10,12‐dione ), ‐acetoxy‐11 ‐hydroxynorverticilla‐4(18),7‐diene‐10,12‐dione (−)‐(1...

The methanolic extract of the root wood Michelia compressa (Maxim.)Sargent showed cytotoxicity against MCF-7, NCI-H460 and SF-268 cancer cell lines.Bioassay-guided fractionation chloroform-soluble layer led to isolation costunolide liriodenine with cytotoxic activities, along twenty-seven known compounds.The active existed as major constituent in this study.

Abstract A phytochemical investigation of the MeOH extract Illicium arborescens yielded two new phytoquinoid epimers, 2,3‐didehydro‐5‐ O ‐methyl‐11‐epiillifunone E ( 1 ) and ‐methylillifunone 2 ), as well five sesquiterpene lactones (8,9‐secoprezizaane‐type sesquiterpenes). Two them, i.e. , 3 4 were minwanensin‐type sesquiterpenes, other two, 5 6 had anisatin‐type (or floridanolide type) skeleton, fifth, 7 was a dunnianin‐type sesquiterpene. Their structures established by analyses 1D‐...

Four new oxygenated dibenzocyclooctadiene lignans, arisanschinins A–D (1–4), and a 1,4-bis(phenyl)-2,3-dimethylbutane lignan, arisanschinin E (5), together with 15 known compounds, were isolated from the EtOAc-soluble fraction of aerial parts Schisandra arisanensis Hay. The structures 1–5 elucidated on basis extensive spectroscopic analyses, including 2D NMR (HMQC, HMBC, NOESY) experiments. configurations biphenyl octadiene moieties deduced circular dichroism (CD) NOESY spectra,...

Natural products and chemical analogues are widely used in drug discovery, notably cancer infectious disease pharmacotherapy. Sarcophyton convolutum (Alcyoniidae) a Red Sea-derived soft coral has been shown to be rich source of macrocyclic diterpenes cyclized derivatives. Two previously undescribed polyoxygenated cembrane-type diterpenoids, sarcoconvolutums F (1) G (2), as well four identified (3-6) together with furan derivate (7) were isolated from solvent extract. Compounds by...

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Abstract Five new taxoids, including a 2(3→20)‐ abeo ‐taxane with 6/10/6‐membered ring system and four 3,8‐ seco ‐taxanes having 6/12‐membered system, were isolated from an acetone extract of the leaves twigs Taiwanese yew ( Taxus sumatrana , Taxaceae). The structures established as 2 α ,7 β ,10 ‐triacetoxy‐5 ‐hydroxy‐2(3→20)‐ ‐taxa‐4(20),11‐dien‐9,13‐dione 1 ), (3 E ,8 )‐2 ,9,10 13 ,20‐pentaacetoxy‐7 ‐hydroxy‐3,8‐secotaxa‐3,8,11‐trien‐5‐one ,13 ,20‐pentaacetoxy‐5...

Stereospecific olefin (C=C) and carbonyl (C=O) reduction of the readily available prochiral compound ketoisophorone (2,2,6-trimethyl-2-cyclohexene-1,4-dione) (1) by Marchantia polymorpha Nicotiana tabacum cell suspension cultures produce chiral products (6R)-levodione (2), (4R,5S)-4-hydroxy-3,3,5-trimethylcyclohexanone (3), (4R,6R)-actinol (4) as well minor components (4R)-hydroxyisophorone (5) (4S)-phorenol (6).