A5037874477- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- HIV Research and Treatment
- Reproductive System and Pregnancy
- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
- Neurological Complications and Syndromes
- Immune Response and Inflammation
- Polyomavirus and related diseases
- Parvovirus B19 Infection Studies
- Organ Donation and Transplantation
- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Blood groups and transfusion
- Renal and Vascular Pathologies
- Metabolism and Genetic Disorders
- Complement system in diseases
- Transplantation: Methods and Outcomes
- Toxoplasma gondii Research Studies
- Viral Infections and Vectors
Heidelberg University
2012-2023
Commonwealth Scientific and Industrial Research Organisation
2023
Babol University of Medical Sciences
2013-2022
Isfahan University of Medical Sciences
2005-2022
University Hospital Heidelberg
2013-2017
Mazandaran University of Medical Sciences
2015
Mashhad University of Medical Sciences
2013
Institute of Immunology
2009-2010
Zero to Three
2009
Weatherford College
2009
Summary The proteasome constitutes the central proteolytic component of highly conserved ubiquitin–proteasome system, which is required for maintenance and regulation basic cellular processes, including differentiation, proliferation, cell cycling, gene transcription apoptosis. Here we show that inhibition proteasomal activity by inhibitors bortezomib lactacystin suppresses essential immune functions human CD4 + T cells activated allogeneic dendritic (DCs). In cells, induces apoptosis...
Abstract Background Hantaviruses of the family Bunyaviridae are emerging zoonotic pathogens which cause hemorrhagic fever with renal syndrome (HFRS) in Old World and hantavirus pulmonary (HPS) New World. An immune-mediated pathogenesis is discussed for both syndromes. The aim our study was to investigate cytokine expression during course acute Puumala infection. Results We retrospectively studied 64 patients hospitalised infection 2010 a epidemic Germany. Hantavirus confirmed by positive...
Most hepatocellular carcinomas (HCCs) are diagnosed at an advanced stage. The prognostic value of serum tumour markers alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) is limited. aim our study to evaluate the diagnostic growth factors, apoptotic inflammatory mediators cirrhotic patients with without HCC.Serum samples were collected from potential liver transplant (LTx) (n=61) HCC (n=78) as well healthy controls (HCs; n=39). Serum concentrations CRP, neopterin IL-6...
Reliable markers for assessing the biological effect of immunosuppressive drugs and identification transplant recipients at risk developing rejection are not available.In a prospective multicenter study, we investigated whether posttransplant measurement T-cell activation marker soluble CD30 (sCD30) can be used estimating graft loss in kidney recipients. Pre- sera 2322 adult deceased-donor were tested serum sCD30 content using commercial enzyme-linked immunosorbent assay.sCD30 decreased...
The polyclonal rabbit antithymocyte and anti-T-cell immunoglobulins (ATGs) Thymoglobulin (TG) ATG-Fresenius S (ATG-F) have been widely used for the prevention therapy of allograft rejection graft versus host disease in transplantation. Although immunosuppressive mechanisms ATGs on T cells are well studied, less is known about their impact dendritic (DCs).Effects TG ATG-F immune functions signaling pathways human monocyte-derived DCs were determined by flow cytometry, enzyme-linked...
Background. Adverse events occurring early after kidney transplantation were reported to influence graft outcome. Methods. In a prospective multicenter study initiated in 2001, we investigated the relationship between human leukocyte antigen (HLA) alloantibodies, adverse events, and Results. Pretransplant presence of HLA class I antibodies was associated with higher rate no immediate function (NIF) (odds ratio [OR] 1.78, P=0.023) acute rejection episodes (ARE) during first 3 months (OR 2.53,...
In this retrospective study, we tried to define pre- and post-transplant immunological parameters that identify patients at risk for early acute rejection. Lymphocyte subpopulations plasma levels of cytokines neopterin were determined in 32 renal transplant recipients with biopsy-proven graft Recipients without rejection served as controls. High pre-transplant interferon-gamma (IFN-gamma) (p = 0.006), consistently high 0.008), a switch from Th1 Th2 cytokine pattern decreasing IFN-gamma...
The ubiquitin-proteasome pathway is the principal system for extralysosomal protein degradation in eukaryotic cells, and essential regulation maintenance of basic cellular processes, including differentiation, proliferation, cell cycling, gene transcription apoptosis. 26S proteasome, a large multicatalytic protease complex, constitutes system's proteolytic core machinery that exhibits different activities residing defined proteasomal subunits. We have identified proteasome inhibitors -...
Defective regulatory components of the immune system seem to contribute HIV disease progression. Highly active antiretroviral therapy (HAART) was reported restore malfunctioning immunologic components. To corroborate this hypothesis, we studied different dendritic-cell (DC) and T-cell subsets with phenotype in 41 clinically stable patients hemophilia more than 25 years after infection 10 initiation HAART. Compared healthy controls, showed normal DC1 DC2 levels, increased CD8 peripheral blood...
Objective. Pre- and posttransplant predisposing factors for cytomegalovirus (CMV) activation disease are not well defined. The aim of this study was to examine whether there differences in plasma cytokine levels pretransplant, before during CMV replication renal transplant recipients. Material Methods. We studied 76 recipients whom CMV-DNA at regular intervals posttransplant. Thirty-eight patients developed viremia (CMV-DNA-positive). had no detectable (CMV-DNA-negative). Cytokine...
Polyomavirus BK (BKV) has emerged as an important complication after kidney transplantation. BKV-associated nephropathy develops in approximately 5% to 8% of renal transplant recipients, and its prognosis is poor. The relationship between urine cytokines viruria recipients not been defined.We compared posttransplant cytokine levels 65 outpatients with (BK-positive) or without (BK-negative, n=33), low- (n=16) high-level viral load (VL), 24 healthy controls (HCs). Soluble interleukin-1...