A5033436399- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Adipose Tissue and Metabolism
- Physics of Superconductivity and Magnetism
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Magnetic and transport properties of perovskites and related materials
- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Sleep and Wakefulness Research
- Biochemical Analysis and Sensing Techniques
- Superconducting Materials and Applications
- Allergic Rhinitis and Sensitization
- Hearing, Cochlea, Tinnitus, Genetics
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Advanced Chemical Sensor Technologies
- Advanced Condensed Matter Physics
- Neuroscience and Neuropharmacology Research
- Muscle Physiology and Disorders
- Neuroscience and Neural Engineering
- Mast cells and histamine
- Circadian rhythm and melatonin
The University of Tokyo
1997-2025
Bunkyo University
2024
Pharmaceuticals and Medical Devices Agency
2017-2018
Département Santé Animale
2017
University of California, Davis
2003-2013
Yokohama National University
2005-2008
West Health
2007
Dalhousie University
1999-2003
The University of Texas Medical Branch at Galveston
1998-1999
Graphical Abstract figure legend In the mammalian fetal (immature) heart, cardiomyocytes proliferate and can regenerate in a low-oxygen environment. lead up to after birth, major changes occur that result regeneration no longer being possible; however, timing of these events varies across species. Factors regulate this cardiomyocyte transition include nutrient oxygen availability, hormones microRNAs. An emerging field research is use biomarkers as non-invasive detection method for...
Substance P modulates the reflex regulation of respiratory function by its actions both peripherally and in CNS, particularly nucleus tractus solitarii (NTS), first central site for synaptic contact lung airway afferent fibres. There is considerable evidence that substance NTS augment output, but precise effects on transmission have not yet been determined. Therefore, we determined at synapses using whole-cell voltage clamping an slice preparation. Studies were performed second-order neurons...
Infants and young children experiencing extended exposure to secondhand smoke (SHS) have an increased occurrence of asthma, as well cough, wheeze, mucus production airway hyper-reactivity. Plasticity in lung reflex pathways has been implicated causing these symptoms, changes substance P-related mechanisms. Using whole-cell voltage-clamp recordings immunohistochemistry brainstem slices containing anatomically identified second-order afferent nucleus tractus solitarius (NTS) neurons, we...
Abstract Spider mechanosensory neurons receive an extensive network of efferent synapses onto their sensory dendrites, somata and distal axonal regions. The function these is unknown. Peripheral are also found on crustacean stretch‐receptor but not afferents other species, although inhibitory GABAergic a common feature centrally located axon terminals. Here we investigated the effects GABA receptor agonists antagonists one group spider neurons, slit sense organ VS‐3, which accessible to...
We studied the properties of voltage-activated outward currents in two types spider cuticular mechanoreceptor neurons to learn if these contribute differences their adaptation properties. Both adapt rapidly sustained stimuli, but type A usually only fire one or action potentials, whereas B can bursts lasting several hundred milliseconds. found that both had current components, 1) a transient activated when stimulated from resting potential and inactivated with maintained stimuli 2)...
Low-voltage-activated Ca 2+ currents (LVA- I ) are believed to perform several roles in neurons such as lowering the threshold for action potentials, promoting burst firing and oscillatory behavior, enhancing synaptic excitation. They also may allow rapid increases intracellular concentration. We discovered LVA- both members of paired mechanoreceptor a spider, where one neuron adapts rapidly (Type A) other slowly B) response step stimulus. To learn if contributed difference adaptation we...
The nucleus tractus solitarius (NTS) is essential for orchestrating baroreflex control of blood pressure. When a change in pressure occurs, the information transmitted by baroreceptor afferent fibers to central network glutamate binding ionotropic receptors on second-order neurons. Glutamate also activates presynaptic group II and III metabotropic (mGluRs), depressing both GABA release modulate signal transmission. Here we present novel role postsynaptic mGluRs further fine-tune transmission...
Bronchoconstriction in asthmatic patients is frequently associated with gastroesophageal reflux. However, it still unclear whether bronchoconstriction originates from the esophagus or aspiration of refluxate into larynx and larger airway. We compared effect repeated esophageal laryngeal instillations HCl-pepsin (pH 1.0) on tracheal smooth muscle activity eight anesthetized artificially ventilated dogs. Saline was used as control. pressure cuff an endotracheal tube (Pcuff) a direct index at...
This study was performed to evaluate the characteristics of esophageal receptors in anesthetized and artificially ventilated dogs. The electrical activity afferents recorded from peripheral cut end cervical vagus nerve. A cuffed catheter inserted into esophagus at level third tracheal ring used establish location endings. Most were localized intrathoracic portion esophagus. majority studied (36 43) showed a slow adaptation maintained stretch wall. Vagal cooling blocked receptor temperatures...
Voltage-activated sodium current ( I Na ) is primarily responsible for the leading edge of action potential in many neurons. While generally activates rapidly when a neuron depolarized, its inactivation properties differ significantly between different neurons and even within one neuron, where often has slowly inactivating components. been suggested to regulate firing frequency some cells, but no clear picture this relationship emerged. We studied both members paired mechanosensory spider...
The nucleus tractus solitarius (NTS) is essential for coordinating baroreflex control of blood pressure. baroreceptor sensory fibers make glutamatergic synapses onto second-order NTS neurons. Glutamate spillover activates Group II and III presynaptic metabotropic glutamate receptors (mGluRs) on the central terminals to inhibit synaptic transmission, but role postsynaptic mGluRs less understood. We used whole cell patch-clamping in anatomically identified neurons a brain stem slice test...
BACKGROUND AND PURPOSE Second‐hand tobacco smoke (SHS) exposure in children increases the risk of asthma and sudden infant death syndrome. Epidemiological experimental data have suggested SHS can alter neuroplasticity CNS, associated with substance P. We hypothesized that to young primates changed effect P on plasticity neurons nucleus tractus solitarius (NTS), where airway sensory information is first processed CNS. EXPERIMENTAL APPROACH Thirteen‐month‐old rhesus monkeys were exposed...
Combretastatin A4 (CA4) inhibits microtubule polymerization, and clinical trials of the prodrug, CA4 disodium phosphate (CA4DP), as an anti-cancer agent have been conducted. However, CA4DP has not marketed to date because margin between effective dose cardiotoxic is insufficient. Meanwhile, bromodomain-containing protein 4 (BRD4) reported be required for recovery from mitotic arrests induced by anti-microtubule drugs. BRD4 also involved in progression heart failure. Therefore, we...
Abstract Extended exposure to secondhand smoke (SHS) in infants and young children increases the incidence of cough, wheeze, airway hyper‐reactivity prevalence earlier onset asthma. The adverse effects may result from environmentally‐induced plasticity neural network regulating cough function. Using whole‐cell patch‐clamp recordings brainstem slices containing anatomically identified second‐order lung afferent neurons nucleus tractus solitarius (NTS), we determined extended SHS guinea pigs...