A5041276970- Axon Guidance and Neuronal Signaling
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Developmental Biology and Gene Regulation
- Cellular transport and secretion
- Nerve injury and regeneration
- Microtubule and mitosis dynamics
- Protein Tyrosine Phosphatases
Montreal Clinical Research Institute
2019-2024
McGill University
2019-2024
Max Planck Institute of Experimental Medicine
2019-2021
Mirror movements (MM) disorder is characterized by involuntary on one side of the body that mirror intentional opposite side. We performed genetic characterization a family with autosomal dominant MM and identified ARHGEF7, RhoGEF, as candidate gene. found Arhgef7 its partner Git1 bind directly to Dcc. Dcc receptor for Netrin-1, an axon guidance cue attracts commissural axons midline, promoting midline crossing tracts. show are required Netrin-1-mediated act multifunctional effector complex....
While the neural circuits mediating normal, adaptive defensive behaviors have been extensively studied, substantially less is currently known about network mechanisms by which aberrant, pathological anxiety encoded in brain. Here we investigate mice how deletion of Neuroligin-2 (Nlgn2), an inhibitory synapse-specific adhesion protein that has associated with and other psychiatric disorders, alters communication between key brain regions involved behaviors. To this end, performed multi-site...
Abstract Inhibitory synaptic transmission plays a key role in the circuits underlying anxiety behaviors, but network mechanisms by which disruptions inhibition contribute to pathological processing remain largely unknown. Here we addressed this question mice lacking inhibitory synapse-specific adhesion protein Neuroligin-2 (Nlgn2), display widespread reduction as well pronounced phenotype. To investigate how lack of alters communication between brain regions processing, recorded local field...