A5085013012- Nanoplatforms for cancer theranostics
- Viral Infections and Vectors
- Nitric Oxide and Endothelin Effects
- interferon and immune responses
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Photoacoustic and Ultrasonic Imaging
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- Receptor Mechanisms and Signaling
- Angiogenesis and VEGF in Cancer
- Ferroptosis and cancer prognosis
University College London
2023-2024
Imperial College London
2020-2021
Abstract Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma 1 . Loss of FH the kidney elicits several oncogenic signalling cascades through accumulation oncometabolite 2 However, although long-term consequences loss have been described, acute response has not so far investigated. Here we generated an inducible mouse model to study chronology kidney. We show that leads early alterations mitochondrial morphology release DNA (mtDNA) into cytosol, where...
Background: There is an urgent need to understand the complex relationship between cross-reactive anti-viral immunity, disease susceptibility and severity in face of differential exposure related, circulating Flaviviruses. Co-exposure Dengue virus Zika Brazil a case point. A devastating aspect 2015-2016 South American outbreak was dramatic increase numbers infants born with microcephaly mothers exposed during pregnancy. It has been proposed that this more likely ensue from infection women...
Fluorescence lifetime imaging (FLIM) and confocal fluorescence studies of a porphyrin-based photosensitiser (meso-tetraphenylporphine disulfonate: TPPS2a) were evaluated in 2D monolayer cultures 3D compressed collagen constructs human ovarian cancer cell line (HEY). TPPS2a is known to be an effective model for both Photodynamic Therapy (PDT) Photochemical Internalisation (PCI). This microspectrofluorimetric study aimed firstly investigate the uptake subcellular localisation TPPS2a, evaluate...
Blood outgrowth smooth muscle cells (BO-SMCs) offer the means to study vascular without requirement for surgery providing opportunities drug discovery, tissue engineering, and personalized medicine. However, little is known about these which meant that their therapeutic potential remains unexplored. Our objective was investigate first time ability of BO-SMCs vessel-derived sense thromboxane mimetic U46619 by measuring intracellular calcium elevation contraction. (10-6 M) increased cytosolic...