A5049205923- Potassium and Related Disorders
- Long-Term Effects of COVID-19
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Immunotoxicology and immune responses
- Bone Metabolism and Diseases
- Nitric Oxide and Endothelin Effects
- Cytomegalovirus and herpesvirus research
- Animal testing and alternatives
- Cancer Treatment and Pharmacology
- Histone Deacetylase Inhibitors Research
- HER2/EGFR in Cancer Research
- Antifungal resistance and susceptibility
- Electrolyte and hormonal disorders
- Parathyroid Disorders and Treatments
- Multiple Myeloma Research and Treatments
- Anorectal Disease Treatments and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver physiology and pathology
- Magnesium in Health and Disease
- Inflammatory Myopathies and Dermatomyositis
- Clinical Laboratory Practices and Quality Control
- Bone and Dental Protein Studies
- Pathogenesis and Treatment of Hiccups
Teikyo University
2025
Osaka Metropolitan University
2022-2024
Imperial College London
2018-2024
Ibaraki University
2023
Showa University
2021-2023
Daiichi-Sankyo (Japan)
2018-2021
Daiichi Sankyo (United States)
2013
Drug Safety Research Unit
2012
Kyoto University
1990
Abstract Long-term sequelae of the coronavirus disease (COVID-19) constitute Long COVID. Although COVID has been reported globally, its risk factors and effects on quality life (QOL) remain unclear. We conducted a cross-sectional study using questionnaires electronic medical records COVID-19 patients who were diagnosed or hospitalized at five facilities in Japan. Responses obtained from 285 out 1,150 patients. More than half participants symptoms varying severity 1 year after COVID-19....
Lactate, which is synthesized as an end product by lactate dehydrogenase A (LDHA) from pyruvate during anaerobic glycolysis, has attracted attention for its energy metabolism and oxidant effects. novel histone modification-mediated gene regulation mechanism termed lactylation was recently discovered. The present study examined the involvement of in undifferentiated cells that underwent differentiation into osteoblasts. C2C12 cultured medium with a high glucose content (4500 mg/L) showed...
Abstract Background Coronavirus disease 2019 (COVID‐19)‐associated pulmonary aspergillosis (CAPA) is one of the noticeable complications COVID‐19 and its incidence varies widely. In Japan, research on incidence, risk factors mortality associated with CAPA limited. Objectives This study aimed to explore potential for in patients severe or critical evaluate relationship between COVID‐19. Methods We investigated using administrative claims data from acute care hospitals Japan. employed...
IMPORTANCE The association between obesity and response to cancer treatment survival remains unclear, with conflicting findings from various studies. optimal choice conventional chemotherapy immunotherapy for first-line uncertain in patients who potentially have an inadequate therapeutic immunotherapy. OBJECTIVE To investigate whether body mass index (BMI) modifies the of or therapy overall advanced non–small cell lung (aNSCLC). DESIGN, SETTING, PARTICIPANTS A retrospective cohort study,...
Advancements in immunotherapy, the phenomenon of hyperprogression cancer patients, have garnered increasing attention. We herein report a case acute adult T-cell leukemia/lymphoma (ATL) that developed after administration PD-L1 inhibitor durvalumab patient with lung cancer. Although was carrier human leukemia virus type 1 (HTLV-1), this unknown prior to treatment. HTLV-1 bZIP factor detected formalin-fixed lymph node tissue, confirming diagnosis ATL. Our findings suggest potential...
Abstract In patients with X-linked hypophosphatemic rickets/osteomalacia (XLH) in Asia, the current prevalence of hyperparathyroidism and its association renal dysfunction have not been determined. We used patient data retrospectively collected up to time informed consent SUNFLOWER study, a long-term observational investigate treatment status comorbid XLH Japan South Korea. Of 69 who met eligibility criteria, 32 (46.4%) did (hereinafter referred as non-hyperparathyroidism), 33 (47.8%) had...
Background/Objectives: Intrahepatic cholangiocarcinoma (ICC) is subclassified into small and large duct types. Although these subclassifications may help determine the appropriate treatment strategy, subclassification diagnosis currently depends on postoperative pathological examinations. This study aimed to establish a nomogram predict ICC subclassifications. Methods: included 126 patients with who underwent liver resection. The participants were divided duct-type groups. A was developed...
To develop a rat T-cell-dependent antibody response (TDAR) model evaluating both primary and secondary responses, keyhole limpet hemocyanin (KLH) was used to immunize rats twice during 14-day course of study, pattern closely linked that short-term general toxicity study. Female four representative strains (e.g., Sprague-Dawley, Wistar, Fischer, Lewis) were immunized with intravenous administrations KLH (300 µg/rat) on Days 5 9 treatment regimen cyclophosphamide (CPA) at 1, 3, or 6 mg/kg/day....
Abstract Background Few studies have investigated fracture risk and mortality in a Japanese chronic kidney disease (CKD) stages G3–5 population using large-scale clinical database. Methods This retrospective cohort study extracted data from 1 April 2008 to 30 2023. A single age–sex-matched control without CKD was matched with each non-dialysis (estimated glomerular filtration rate < 60 mL/min/1.73 m 2 ) patient. The incidences of all hip fractures all-cause after the index date were...
A specific substrate to Mu class glutathione <i>S</i>-transferase (GST), 1,2-dichloro-4-nitrobenzene (DCNB), was administered mice with a disrupted <i>GST 1</i> gene (<i>Gstm1</i>-null mice) investigate the in vivo role of murine <i>Gstm1</i> toxicological responses DCNB. single oral administration DCNB at doses 500 and 1000 mg/kg demonstrated marked increase blood methemoglobin (MetHB) <i>Gstm1</i>-null but not wild-type mice. Therefore, were considered be more predisposed methemoglobinemia...
Abstract Amine quantification is an important strategy in patient stratification and personalised medicine. This because amines, including amino acids methylarginines impact on many homeostatic processes. One pathway regulated by amine levels nitric oxide synthase (NOS). NOS of (i) the substrate, arginine, (ii) which cycle with arginine (iii) methylarginine inhibitors NOS. However, biomarker research this area hindered lack a unified analytical platform. Thus, development common metabolomics...
T-cell dependent antibody response (TDAR) incorporating both primary and secondary responses to keyhole limpet hemocyanin (KLH) in canine models have not yet been fully understood. To develop a practical dog TDAR model, we characterized by intravenous or intramuscular immunization of KLH twice at intervals 8 days during 28-day course study. Primary with routes induced maximum IgM on 6 after the treatment, whereas IgG started treatment relatively low levels. Remarkable increases anti-KLH...
Abstract Objective This study aimed to establish a screening model for differentiating anti-synthetase syndrome (ASS) from other ANA-associated rheumatic diseases (AARDs) using combination of cytoplasmic and non-cytoplasmic ANA (ncANA) patterns. Methods : retrospective observational included patients with AARDs such as SLE, SSc, SS, MCTD PM/DM who underwent between April 2012 December 2021. Variables age, sex, patterns (Cytoplasmic ncANA) titres. Logistic regression analysis Cytoplasmic...
Blood vessels are comprised of endothelial and smooth muscle cells. Obtaining both types cells from living donors is not possible without invasive surgery. To address this, we have devised a strategy whereby human derived blood progenitors the same donor could be cultured with autologous leukocytes to generate "vessel in dish" bioassay. Autologous sets outgrowth (BOECs), (BO-SMCs), were obtained four donors. Cells treated monoculture cumulative coculture conditions. The specific mediator...
Objectives: Excisional hemorrhoidectomy (EH) is sometimes same-day surgery under local anesthesia (LA); however, the LA injection can be painful. We conducted an open-label, crossover, randomised controlled trial to evaluate efficacy and safety of pre-cooling in reducing pain associated with injection.
Background Patients with chronic kidney disease (CKD) were excluded in most trials that investigated the effects of urate-lowering agents, such as febuxostat and allopurinol, hyperuricemic patients. This exclusion leads to uncertainty regarding efficacy patients CKD. Due high prevalence hyperuricemia CKD, we aimed assess effect on improving patient outcomes concerning cardiovascular events survival compared those treated allopurinol among Methods We conducted a retrospective cohort study...