A5030418541- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Protist diversity and phylogeny
- Vector-borne infectious diseases
- Gut microbiota and health
- Bacteriophages and microbial interactions
- Toxin Mechanisms and Immunotoxins
- dental development and anomalies
- Insect symbiosis and bacterial influences
- Scientific Computing and Data Management
- Bartonella species infections research
- Environmental DNA in Biodiversity Studies
Uppsala University
2013-2018
Science for Life Laboratory
2013-2018
Gene transfer agents (GTAs) randomly short fragments of a bacterial genome. A novel putative GTA was recently discovered in the mouse-infecting bacterium Bartonella grahamii. Although GTAs are widespread phylogenetically diverse bacteria, their role evolution is largely unknown. Here, we present comparative analysis 16 genomes ranging from 1.4 to 2.6 Mb size, including six isolated cow, two moose, dogs, and kangaroo. phylogenetic tree inferred 428 orthologous core genes indicates that deadly...
Little is known about the diversity and structuring of freshwater microbial communities beyond patterns revealed by tracing their distribution in landscape with common taxonomic markers such as ribosomal RNA. To address this gap knowledge, metagenomes from temperate lakes were compared to selected marine metagenomes. Taxonomic analyses rRNA genes these confirm previously reported dominance a limited subset uncultured lineages bacteria, whereas Archaea rare. Diversification into was also...
Abstract Background The SAR11 group of Alphaproteobacteria is highly abundant in the oceans. It contains a recently diverged freshwater clade, which offers opportunity to compare adaptations salt- and freshwaters monophyletic bacterial group. However, there are no cultivated members genomes have been sequenced yet. Results We isolated ten single cells from three lakes assembled their genomes. A phylogeny based on 57 proteins indicates that organized into distinct microclusters. show evolved...
The origin of eukaryotes represents an enigmatic puzzle, which is still lacking a number essential pieces. Whereas it currently accepted that the process eukaryogenesis involved interplay between host cell and alphaproteobacterial endosymbiont, we lack detailed information regarding identity nature these players. A studies have provided increasing support for emergence eukaryotic from within archaeal domain life, displaying specific affiliation with TACK superphylum. Recent shown genomic...
Background The Neanderthal genome was recently sequenced using DNA extracted from a 38,000-year-old fossil. At the start of project, fraction mammalian and bacterial in sample estimated to be <6% 9%, respectively. Treatment with restriction enzymes prior sequencing increased relative proportion 15%, but large majority sequences remain uncharacterized. Principal Findings Our taxonomic profiling 3.95 Gb isolated Vindija Vi33.16 fossil showed that 90% about 50,000 rRNA gene sequence reads were...