A5007095434- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Cardiac and Coronary Surgery Techniques
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Metabolism and Genetic Disorders
- Acute Myocardial Infarction Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Amino Acid Enzymes and Metabolism
- Vascular Procedures and Complications
- Cardiac tumors and thrombi
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Aortic aneurysm repair treatments
- Cardiovascular Effects of Exercise
- Thyroid Disorders and Treatments
Kerckhoff Klinik
2010-2025
St.-Johannes-Hospital Dortmund
2016-2025
Carl von Ossietzky Universität Oldenburg
2021-2025
Czech Academy of Sciences, Institute of Microbiology
2024
German Centre for Cardiovascular Research
2014-2017
Justus-Liebig-Universität Gießen
2013-2014
Leipzig University
2007-2011
Leipzig Heart Institute
2008-2010
Deutsches Herzzentrum der Charité
2007-2010
University of Toronto
1955-1963
Peri-procedural transcatheter valve embolization and migration (TVEM) is a rare but potentially devastating complication of aortic implantation (TAVI). We sought to assess the incidence, causes, outcome TVEM in large multicentre cohort.We recorded cases peri-procedural patients undergoing TAVI between January 2010 December 2017 from 26 international sites. occurred 273/29 636 (0.92%) (age 80.8 ± 7.3 years; 53.8% female), which 217 were ascending aorta 56 left ventricle. The use...
Extracorporeal life support (ECLS) has shown encouraging survival rates in patients with in-hospital cardiac arrest; however, its routine use is still controversial. We compared the of arrest receiving conventional cardiopulmonary resuscitation (CCPR) to that ECLS as an adjunct (ECPR).A total 353 (272 CCPR and 52 ECPR) were included this retrospective, propensity score-adjusted (1:1 matched), single-centre study. Primary endpoints at 30 days, long-term neurological outcome defined by...
The precise sizing of the aortic annulus is crucial in order to select most appropriate valve size for transcatheter implantation (TAVI). Owing closed heart situation TAVI, has be performed based on preoperative imaging when compared with direct during conventional procedures. aim study was evaluate either by CT-scan or echocardiography comparing these imaging-based measurements intraoperative sizing.Prior standard replacement, 26 patients underwent cardiac and echocardiographic examination....
Contrast agent is a potential risk factor for acute kidney injury (AKI). Little known about the incidence of contrast-induced nephropathy (CIN) after trans-apical aortic valve implantation (TA-AVI) and on impact contrast exposure during preoperative computed tomography (CT) scan cardiac catheterization.A total 270 consecutive high-risk patients received TA-AVI symptomatic stenosis 3-year period. Different preoperative, peri-procedural, postoperative variables were analyzed by uni-...
Background— Transapical aortic valve implantation has evolved to a reproducible therapeutic option for high-risk patients. The aim of the present study was evaluate our learning experience over 4 years and analyze outcome-related risk factors. Methods Results— A total 299 patients who received transapical between February 2006 January 2010 with Edwards SAPIEN transcatheter prosthesis were analyzed according early (EE; 1 150) recent (RE; 151 299). Patients consistently demonstrated high...
We analysed the number of procedures, complications, and in-hospital mortality rates all patients undergoing transvascular transcatheter aortic valve implantation (TV-TAVI) in comparison to isolated surgical replacement (iSAVR) from 2014 2016 Germany.All procedures performed Germany are mandatorily registered a quality control program. More than 15 000 TV-TAVI were Germany. Especially post-procedural complications declined within last few years, including new pacemaker implantations (2015:...
Rationale: Inflammation in the setting of acute myocardial infarction (MI) has been linked to risk stratification; however, release kinetics inflammatory biomarkers patients with MI difficult establish. Objective: The aim this study was determine changes levels several specifically inflammation after transcoronary ablation septal hypertrophy, a procedure that mimics MI. Methods and Results: We analyzed C-reactive protein, high-sensitivity interleukin-6, soluble CD40 ligand, peripheral blood...
Acute kidney injury (AKI) is a complication after major cardiac surgery that associated with higher rates of morbidity and mortality. MicroRNA-21 (miR-21) has been described as an early biomarker for AKI. We investigated whether miR-21 predictive AKI long-term mortality surgery. Consecutive patients (n = 115) undergoing were included. Serum creatinine was measured prior to, 4 h after, 1, 7 days extracorporeal circulation. Diagnosis post-operative made in accordance the international Kidney...
ABSTRACT Background Transcatheter aortic valve implantation (TAVI) without predilatation has fewer procedural steps and thereby potentially complications. This been demonstrated for the antegrade transapical access; however, whether TAVI can be safely performed using retrograde transfemoral route is unknown. Hypothesis We postulated that feasible with a balloon‐expandable device route. Methods Twenty‐six consecutive patients stenosis of native (AV) undergoing Edwards SAPIEN XT prosthesis...
Based upon recent developments in transcatheter technology, this study was designed to evaluate the feasibility and haemodynamic performance of valve-in-a-ring (VinR) implantation for potentially failed mitral repair using a minimally invasive, transatrial, off-pump approach.Adult sheep (54.3+/-3.0 kg) underwent valve with 26 mm complete annuloplasty ring (Physio) standard conventional techniques. To simulate redo operation, 23 pericardial prosthesis (Edwards Sapien) mounted on...
Background. Contrast-induced acute kidney injury (CI-AKI) occurs in up to 13% of patients undergoing percutaneous coronary intervention (PCI). Neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for renal impairment. We investigated whether increased urinary NGAL concentrations were predictive CI-AKI within 2 days after PCI or a higher re-hospitalization rate 9 months. Methods. Consecutive (n = 128), with stable heart disease and eGFR ≥ 30 mL/min/1.73 m2, included. Venous...
Acute kidney injury (AKI) is a common complication after cardiac surgery. Neutrophil gelatinase-associated lipocalin (NGAL) may be an early biomarker for surgery-associated (CSA) AKI. We investigated whether increased urinary NGAL concentrations were predictive of AKI within 4 days surgery and mortality 9 months.Consecutive patients (n = 141) undergoing major included. Creatinine, blood urea nitrogen, cystatin C measured before, hours extracorporeal circulation.AKI was observed in 47 (33.3%)...
Background: Prosthesis-patient mismatch (PPM) has been demonstrated to affect the outcome of both surgical (SAVR) and transcatheter aortic valve replacement (TAVR) patients. Supra-annular valves (SAV) appear offer a superior solution intra-annular (IAV) in this regard. However, data on comparison self-expanding (SE) NAVITOR balloon-expandable (BE) Sapien 3 Ultra small annuli are limited. Methods: A total 179 patients with severe native stenosis were treated either SE (SEV; n = 104) or BE...