A5024040318- Dermatologic Treatments and Research
- Dermatology and Skin Diseases
- Acne and Rosacea Treatments and Effects
- Allergic Rhinitis and Sensitization
- Cutaneous Melanoma Detection and Management
- Axon Guidance and Neuronal Signaling
- Hidradenitis Suppurativa and Treatments
- melanin and skin pigmentation
- Colorectal and Anal Carcinomas
- Parvovirus B19 Infection Studies
- Cell Adhesion Molecules Research
- Facial Rejuvenation and Surgery Techniques
- Empathy and Medical Education
- Autoimmune Bullous Skin Diseases
- Digital Imaging in Medicine
- Contact Dermatitis and Allergies
- Chemotherapy-related skin toxicity
- Angiogenesis and VEGF in Cancer
- Skin Protection and Aging
- Genital Health and Disease
- Urological Disorders and Treatments
- Cutaneous lymphoproliferative disorders research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Streptococcal Infections and Treatments
- Food Allergy and Anaphylaxis Research
University of British Columbia
2020-2025
Women's College Hospital
2025
SKiN Health
2021-2024
University of Toronto
2009-2018
Hospital for Sick Children
2009-2016
Canada Research Chairs
2013
Lunenfeld-Tanenbaum Research Institute
2012
Heart and Stroke Foundation
2012
Canadian Blood Services
2012
St. Michael's Hospital
2012
Background— Cardiac consequences of obesity include inflammation, hypertrophy, and compromised energy metabolism. Glucagon-like peptide-1 is an incretin hormone capable cytoprotective actions that reduces inflammation endoplasmic reticulum stress in other tissues. Here we examine the cardiac effects glucagon-like analog liraglutide a model obesity, independent changes body weight. Methods Results— C57Bl6 mice were placed on 45% high-fat diet (HFD) or regular chow diet. Mice HFD developed...
Cutaneous melanoma (CM) is one of the most fatal types skin cancer. Alarmingly, increases in incidence and mortality were noted globally for this malignancy, despite increase understanding pathogenesis enhanced prevention efforts.Data was extracted CM patients provinces territories (except Quebec) using two independent, population-based registries. Analysis performed both clinical pathological characteristics: tumor morphologic classification, age, sex, anatomic site affected place...
In inflammatory diseases, circulating neutrophils are recruited to sites of injury. Attractant signals provided by many different chemotactic molecules, such that blockade one may not prevent neutrophil recruitment effectively. The Slit family secreted proteins and their transmembrane receptor, Robo, repel axonal migration during CNS development. Emerging evidence shows inhibiting the activation Rho-family GTPases, Slit2/Robo also inhibit other cell types toward a variety factors in vitro...
The utilization of topical formulations containing alpha hydroxy acids (AHAs) has garnered considerable attention. This review summarizes the effectiveness most common AHA formulations, including mechanisms action and future research directions. AHAs have a dramatic impact on diverse skin conditions, enhancing texture stimulating collagen synthesis. Uncertainties persist regarding optimal concentration, pH, vehicle for maximum efficacy. Advancements in formulation technologies offer...
We performed a systematic review of the literature to determine whether earlier surgical repair acute rotator cuff tear (ARCT) leads superior post-operative clinical outcomes.The MEDLINE, Embase, CINAHL, Web Science, Cochrane Libraries, controlled-trials.com and clinicaltrials.gov databases were searched using terms: 'rotator cuff', or 'supraspinatus', 'infraspinatus', 'teres minor', 'subscapularis' AND 'surgery' 'repair'. This gave total 15 833 articles. After deletion duplicates abstracts...
Vascular injury and atherothrombosis involve vessel infiltration by inflammatory leukocytes, migration of medial vascular smooth muscle cells to the intimal layer, ultimately acute thrombosis. A strategy simultaneously target these pathological processes has yet be identified. The secreted protein, Slit2, its transmembrane receptor, Robo-1, repel neuronal in developing central nervous system. More recently, it been appreciated that Slit2 impairs chemotaxis leukocytes toward diverse...
Zusammenfassung Der Lichen sclerosus (LS) ist eine chronisch verlaufende entzündliche Dermatose, die in erster Linie durch Veränderungen der Hautpigmentierung, Genitalarchitektur sowie Pruritus mit begleitender Dyspareunie gekennzeichnet ist. Es gibt Vielzahl von Komplikationen im Zusammenhang LS, gesundheitsbezogene Lebensqualität Patienten darüber hinaus verschlechtern können. Eine systematische Übersichtsarbeit wurde durchgeführt, um Literatur zu den klinischen Merkmalen LS und...