A5086345709- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- Homelessness and Social Issues
- French Urban and Social Studies
- Opioid Use Disorder Treatment
- HIV/AIDS Research and Interventions
- Multiculturalism, Politics, Migration, Gender
- Education, sociology, and vocational training
- Substance Abuse Treatment and Outcomes
- Gambling Behavior and Treatments
- Sex work and related issues
- Hepatitis B Virus Studies
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Hemophilia Treatment and Research
- Food Security and Health in Diverse Populations
- Virus-based gene therapy research
- Adolescent Sexual and Reproductive Health
- Cellular transport and secretion
- Lysosomal Storage Disorders Research
- Sexuality, Behavior, and Technology
- Alcohol Consumption and Health Effects
- Eating Disorders and Behaviors
- Pain Management and Opioid Use
- Blood Coagulation and Thrombosis Mechanisms
École Nationale Supérieure d'Architecture de Nantes
2008-2022
Centre National de la Recherche Scientifique
2022
Nantes Université
2022
Institut National de Santé Publique du Québec
2009-2020
Université de Sherbrooke
2011-2020
Institut National de Santé Publique
2004-2019
Université de Montréal
2017-2019
Centre Hospitalier de l’Université de Montréal
2019
Université Laval
2018
Canadian Institutes of Health Research
2017
Many studies have shown a high prevalence of sexually transmitted diseases, human immunodeficiency virus (HIV) infection, viral hepatitis, drug dependence, and mental health problems among street youth. However, data on mortality these youth are sparse.To estimate rate in Montreal to identify causes death factors increasing the risk death.From January 1995 September 2000, 1013 14 25 years age were recruited prospective cohort with semi-annual follow-ups. Original study objectives determine...
ABSTRACT Aims To examine trends in prescription opioid (PO) injection and to assess its association with hepatitis C virus (HCV) seroconversion among drug users (IDUs). Design Prospective cohort study. Setting Montreal, Canada. Participants HCV‐negative IDUs at baseline, reporting the past month. Measurements Semi‐annual visits included HCV antibody testing an interview‐administered questionnaire assessing risk behaviours. incidence rate was calculated using person–time method. Time‐updated...
Starting in 2007, a 2-year study based on ethnographic methodology was carried out downtown Montréal, Canada. A thematic analysis of observational and interview-based notes conducted. Illicit prescription opioid (PO) use widespread among street-based participants. Injection the main mode PO administration observed users. Some injection practices such as "doing wash" could pose new challenges terms prevention infections. More research is needed to examine role illicit development opiate...
By providing access to affected neurons, human induced pluripotent stem cells (iPSc) offer a unique opportunity model neurodegenerative diseases. We generated iPSc from the skin fibroblasts of children with mucopolysaccharidosis type IIIB. In this fatal lysosomal storage disease, defective α-N-acetylglucosaminidase interrupts degradation heparan sulfate (HS) proteoglycans and induces cell disorders predominating in central nervous system, causing relentless progression toward severe mental...
We aim to estimate HIV prevalence and associated risk factors among street youth in Montreal, Canada. conducted a one-year cross-sectional anonymous study 1995. recruited aged 13-25 years meeting specific criteria for itinerancy through the 20 major Montreal agencies. Participation included structured interview provision of an oral specimen testing. Among 909 subjects studied, 99.3% had been sexually active, 25.9% exchanged sex money, gifts, drugs, place sleep, or other things; 31.8%...
To describe the circumstances of first drug injection among street youth.A cohort study conducted in 1995-2000.Subjects aged 14-25 years old were recruited all major Montreal organizations offering free services to youth.Subjects who reported having ever injected drugs completed questions on their (calendar time, location, type relationship with initiator, presence others, injected, source needle and use clean other materials). Questions characteristics initiator prior added during course...
We used data and leftover samples collected through the SurvUDI network to describe epidemiology of hepatitis C virus (HCV) infection among injection drug users (IDUs) in Eastern Central Canada. Among 1380 selected IDUs, having participated twice or more between 1997 2003, overall HCV prevalence rate was 60.4% (95% confidence interval [CI]: 57.7–63.0%). 543 initially uninfected participants, incidence 27.1 per 100 person-years CI: 23.4–30.9 person-years). Independent predictors...
Notification of hepatitis C virus (HCV) positive status is known to have short-term impacts on subsequent alcohol, drug use and injection behaviors among persons who inject drugs (PWID). It remains be established whether postscreening behavioral changes extend over time for PWID screening test notification has HCV-negative PWID. This study sought longitudinally assess substance after HCV seroconverters PWID.Initially HCV-seronegative (n = 208) were followed prospectively between 2004 2011 in...
The nuclear farnesoid X receptor (FXR) regulates bile acid homeostasis and is a drug target for metabolic liver diseases. FXR also plays an important role in hepatitis B virus (HBV) DNA transcription. In vitro mice, agonist treatment leads to inhibition of viral replication decline proteins, pregenomic RNA (pgRNA) HBV levels. We aimed translate this clinical use by primarily evaluating the safety secondary anti-viral effect Vonafexor, agonist, chronic (CHB) patients. total, 73 CHB patients...
Résumé L’analyse critique des « bonnes pratiques » dans le champ urbain suppose d’identifier qu’elles recouvrent et l’extension de leurs possibles applications. Nous différencions ainsi registres (incitatifs, prescriptifs, normatifs), scènes outils qui les font exister rendent opérantes. Cette généalogie est doublée, un second temps, d’un suivi configurations locales situées pratiques, observées cadre grand projet ville en action à Nantes. Il ressort cet examen que soit renvoient phénomènes...