A5100373350- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- HIV Research and Treatment
- Carbohydrate Chemistry and Synthesis
- Herpesvirus Infections and Treatments
- Soil Carbon and Nitrogen Dynamics
- Virus-based gene therapy research
- Glycosylation and Glycoproteins Research
- Agriculture, Soil, Plant Science
- Immune Cell Function and Interaction
- GABA and Rice Research
- T-cell and B-cell Immunology
- Agronomic Practices and Intercropping Systems
- Biological Control of Invasive Species
- vaccines and immunoinformatics approaches
- thermodynamics and calorimetric analyses
- Food Quality and Safety Studies
- Hydrogels: synthesis, properties, applications
- Peatlands and Wetlands Ecology
- Traditional Chinese Medicine Analysis
- Animal Disease Management and Epidemiology
- Irrigation Practices and Water Management
- Plant responses to water stress
- Forest Ecology and Biodiversity Studies
- Forest, Soil, and Plant Ecology in China
Liaoning Academy of Agricultural Sciences
2025
Icahn School of Medicine at Mount Sinai
2019-2024
Northwest Normal University
2022
Tianjin International Joint Academy of Biomedicine
2017-2022
Chengdu University of Traditional Chinese Medicine
2018
Lanzhou University
2014
Northeast Agricultural University
2008-2013
Eastern Liaoning University
2011
United States Military Academy
2007
Renmin University of China
2004
This study investigated the genetic diversity and genomic variation in wild Cordyceps chanhua populations from four regions China—Dazhou, Sichuan (ICD); Lu’an, Anhui (ICL); Taizhou, Zhejiang (ICT); Yixing, Jiangsu (ICY)—to elucidate differentiation patterns provide a scientific foundation for resource conservation sustainable utilization. Whole-genome resequencing was performed, yielding high-quality sequencing data (Q20 > 98%, Q30 94%, coverage: 93.62–95.79%) enabling detection of 82,428...
Introduction The rapid and precise differential diagnosis of respiratory diseases is crucial to impede the spread viruses, considering substantial demand resulting from frequent co-infections Method A quantum dot nanobeads (QBs)-based multiplex fluorescence lateral flow immunoassay (QBs-based MF-LFA) biosensor was developed. MF-LFA enabled simultaneous sensitive quantification severe acute syndrome coronavirus 2 (SARS-CoV-2), Adenovirus (ADV), Influenza Virus (IAV), boasting low limit...
Porcine epidemic diarrhea virus (PEDV) causes high mortality in pigs. PEDV main protease (Mpro) plays an essential role viral replication. We solved the structure of Mpro complexed with peptidomimetic inhibitor N3 carrying a Michael acceptor warhead, revealing atomic level interactions. further designed series 17 inhibitors altered side groups. Inhibitors M2 and M17 demonstrated enhanced specificity against Mpro. These compounds have potential as future therapeutics to combat infection.
We isolated a bovine viral diarrhea virus (BVDV) from commercial fetal serum and designated it HLJ-10. The complete genome is 12,284 nucleotides (nt); the open reading frame 11,694 nt, coding 3,898 amino acids. Phylogenetic analysis indicated that this strain belongs to BVDV group 2.
The existing zoonotic coronaviruses (CoVs) and viral genetic variants are important microbiological pathogens that cause severe disease in humans animals. Currently, no effective broad-spectrum antiviral drugs against emerging CoVs available. CoV main protease (Mpro) plays an essential role replication, making it ideal target for drug development. However, the structure of Deltacoronavirus Mpro is still unavailable. Porcine deltacoronavirus (PDCoV) a novel belongs to genus causes atrophic...
Bacteria dysbiosis and its accompanying inflammation or compromised mucosal integrity is associated with an increased risk of HIV-1 transmission. However, may also bind bacteria bacterial products to impact infectivity transmissibility. This study evaluated interactions through glycan-binding lectins. The Streptococcal Siglec-like lectin SLBR-N, a part the fimbriae shrouding surface that recognizes α2,3 sialyated O-linked glycans, was noted for ability enhance in context cell-free infection...
One of the greatest challenges in HIV vaccine development is accommodating worldwide sequence diversity HIV-1 virus. To understand how viral may affect potential breadth vaccines designed to elicit antiviral T cell immunity, we have developed novel approaches assess conservation at amino acid level, where effects are exerted. Taking each from LANL 2004 alignments as a or challenge virus, all pairwise combinations sequences were evaluated by two methods: first, traditional comparison aligned...
Cyathula capitate is the main adulterant of C.offinalis. According to literature reported, there are obvious differences in properties, taste and pharmacological activity between C. Therefore, can only be used as a local conventional medicine can't substitute for offinalis. Since appearance C.capitata very similar C.offinalis content cyasterone also reach limit current pharmacopoeia standard, mostly sold form impersonation oradmixture, which seriously affected safety clinical medication...
Introduction Neutralizing antibodies (Abs) are one of the immune components required to protect against viral infections. However, developing vaccines capable eliciting neutralizing Abs effective a broad array HIV-1 isolates has been an arduous challenge. Objective This study sought test aimed induce epitopes at V1V2 apex envelope (Env). Methods Four groups rabbits received DNA vaccine expressing domain CRF01_AE A244 strain on trimeric 2J9C scaffold (V1V2-2J9C) along with protein consisting...
Abstract HIV-1 envelope (Env) is densely shrouded with oligomannose- and complex-type glycans. These glycans interact lectins, a family of carbohydrate-recognizing proteins. We evaluated lectins for the ability to block infection isolates that differ in their sensitivity neutralizing antibodies. The antibody-sensitive tier 1 viruses were blocked by more easily than resistant 2 viruses. When produced glycosidase inhibitors express homogenously oligomannose-type glycans, they became sensitive...