A5072385909- Obesity, Physical Activity, Diet
- Obesity and Health Practices
- Bariatric Surgery and Outcomes
- Child and Adolescent Health
- Mobile Health and mHealth Applications
- Diet and metabolism studies
- Eating Disorders and Behaviors
- Child Nutrition and Feeding Issues
- Child Development and Digital Technology
- Impact of Technology on Adolescents
- Children's Physical and Motor Development
- Health and Lifestyle Studies
- Nitric Oxide and Endothelin Effects
- Nutrition and Health in Aging
- Artificial Intelligence in Healthcare
- Electron Spin Resonance Studies
- Birth, Development, and Health
- Physical Activity and Health
- Machine Learning in Healthcare
- Food Security and Health in Diverse Populations
- Gastroesophageal reflux and treatments
- Traditional Chinese Medicine Studies
- Enzyme function and inhibition
- Cognitive Abilities and Testing
- Sleep and related disorders
Alfred I. duPont Hospital for Children
2011-2018
Thomas Jefferson University
2014-2018
DuPont (United States)
2008-2018
Nemours Children's Health System
2018
Dupont Hospital
2008-2017
RELX Group (United States)
2017
Philadelphia University
2017
RELX Group (United Kingdom)
2017
Jefferson College
2012
American College of Surgeons
2009
Calmodulin-dependent nitric-oxide synthase from bovine brain and GH3 pituitary cells is inhibited by imidazole, 1-phenylimidazole, 2-phenylimidazole, 4-phenylimidazole, with half-maximal inhibition occurring at 200, 25, 160, 600 microM concentrations of inhibitor, respectively. Imidazole inhibits the maximal velocity citrulline formation enzyme, but does not alter concentration arginine, calmodulin, or (6R)-5,6,7,8,-tetrahydro-L-biopterin required for expression activity. Imidazole,...
The antifungal imidazoles miconazole, ketoconazole, and clotrimazole inhibit citrulline formation by nitric-oxide synthase. These agents both increase the concentration of calmodulin required to activate enzyme half-maximally reduce maximal velocity formation. This inhibition was not reversed increased concentrations either arginine substrate or (6R)-5,6,7,8-tetrahydro-L-biopterin. Miconazole, also inhibited cytochrome-c reductase activity synthase competitively versus concentration, with...
A nitric oxide synthase activity stimulated more than 30-fold by the concurrent presence of Ca2+ and calmodulin (CaM), inhibited trifluoperazine (50 microM), has been identified in extracts GH3 pituitary cells. The CaM-dependent crude extract was 9-fold (6R)-5,6,7,8-tetrahydro-L-biopterin with half-maximal stimulation occurring at a concentration 300 nM. Fractionation on DEAE-cellulose enhanced specific up to 300-fold provided preparation which Western blot analysis possessed 152 kDa protein...
Background: There are no existing multisite national data on obese youth presenting for pediatric weight management. The primary aim was to describe BMI status and comorbidities among with obesity management (PWM) at programs within the Pediatric Obesity Weight Evaluation Registry (POWER). Methods: Data were collected from 2009–2010 6737 patients ages 2–17. Patients classified in three groups by (kg/m2) cutoffs percent of 95th percentile BMI: (1) obesity; (2) severe class 2; (3) 3. Weighted...
Objective To determine which anthropometric measure best correlates with change in fat mass (FM) over time. Methods The authors performed a retrospective cohort study of 76 obese patients (mean body index [BMI] 38 kg/m 2 and mean age 13 years) presenting to an obesity clinic between 2005 2010. For each patient, during visits, FM was measured by bioelectrical impedance analysis the following measures obtained: BMI, waist circumference, hip neck circumference. Correlation coefficients linear...
Pediatric primary care providers play a critical role in managing obesity yet often lack the resources and support systems to provide effective children with obesity. The objective of this study was identify system-level barriers desired better from perspective pediatric providers. A 64-item survey electronically administered 159 26 practices within large network. Bivariate analyses were performed compare responses based on provider practice characteristics. Also factor analysis conducted...
Background: The prevalence of severe obesity and electronic game use among youth has increased over time. Methods: We administered a survey assessing gaming psycho-demographic characteristics to aged 11–17 attending five weight management programs. conducted chi-square logistic regression analyses describe the association between class 3 characteristics. Results: Four hundred twelve (51% female, 26% Black, 25% Hispanic, 43% White, 44% with obesity) completed survey. There was stepwise...
Fitness trackers can engage users through automated self-monitoring of physical activity. Studies evaluating the utility fitness are limited among adolescents, who often difficult to in weight management treatment and heavy technology users.We conducted a pilot randomized trial describe impact providing adolescents caregivers with as an adjunct tertiary care clinic on adolescent tracker satisfaction, utilization patterns, activity levels.Adolescents were 1 2 groups (adolescent or dyad) at...
Obesity is a major healthcare problem in youth and their social/electronic media (SEM) use has been described as risk factor. Though much known about the newer technologies to communicate, little what used by those weight management programs. The aim of this study was determine types SEM, including sedentary active video games, programs which they prefer for communicating with providers.This multisite using 24-question online SurveyMonkey® questionnaire. Youth, 12-17 years old, attending...
Prior studies show seven percent to nine of children demonstrate gaming behaviors that affect a child's ability function (e.g., problem gaming), but none have examined the association between and weight status. The objective this study was determine prevalence among enrolled in tertiary management programs. We administered computer-based survey convenience sample aged 11-17 years five geographically diverse pediatric (PWM) programs COMPASS (Childhood Obesity Multi-Program Analysis Study...
The purpose of the present study was to determine whether functional communication and parent-adolescent relations prospectively predict anxiety depression symptoms among severely obese adolescents seeking bariatric surgery. Participants included 30 their primary caregivers, who presented for enrolment in a assessing safety efficacy laparoscopic adjustable gastric band. Adolescents caregivers completed questionnaires symptoms, communication, at baseline immediately prior having Regression...
This study examines the acceptability of adjustable gastric banding surgery compared to other weight-loss treatments in adolescents. Adolescents (N = 102) and their caregivers 101) completed measures assess treatment acceptability, sociodemographic characteristics, quality life. Gastric pills were rated as significantly less acceptable than diet, exercise, family behavior therapy. Acceptability ratings not correlated with body mass index, life, or previous number methods attempted....