A5077655388- Dental Radiography and Imaging
- Endodontics and Root Canal Treatments
- Xenotransplantation and immune response
- Digital Media Forensic Detection
- Advanced Steganography and Watermarking Techniques
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Dental materials and restorations
- Oral microbiology and periodontitis research
- Mesenchymal stem cell research
- Generative Adversarial Networks and Image Synthesis
- Hematopoietic Stem Cell Transplantation
- Vehicle License Plate Recognition
- Gut microbiota and health
- Sirtuins and Resveratrol in Medicine
- Diet, Metabolism, and Disease
- Immunotoxicology and immune responses
- Liver physiology and pathology
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- 3D Surveying and Cultural Heritage
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Metabolism and Genetic Disorders
- Histone Deacetylase Inhibitors Research
Huazhong University of Science and Technology
2024-2025
Nanjing University
2015-2025
ShanghaiTech University
2024
Peking University
2006-2023
National Clinical Research Center for Digestive Diseases
2023
Nanchang University
2022
Stomatology Hospital
2015-2019
Zero to Three
2015
Nanjing Medical University
2014
University of Alberta
1986
Abstract The antitumor effect of luteolin, a plant flavonoid, in gastric cancer (GC) cells has not been fully understood. Here we show that luteolin selectively kills STAT3 overactivated GC are often drug resistant. treatment these significantly inhibited phosphorylation and reduced the expression targeting gene Mcl-1, Survivin Bcl-xl. Silencing SHP-1, protein tyrosine phosphatase, abolished inhibitory on cell apoptosis, suggesting SHP-1 is crucial luteolin-mediated cellular function....
Hashimoto's thyroiditis (HT) is the most common organ-specific autoimmune disease and believed to be a predominately T cell-mediated autoimmunity. Signal transducer activator of transcription (STAT)3 crucial factor immunity, with key roles in proliferation migration helper (Th) cells, differentiation Th cells into Th17 balance between Treg cells. Flavonoid luteolin has been shown markedly inhibit Tyr705 activation/phosphorylation STAT3 exert anti-inflammatory effects multiple sclerosis. In...
Periodontitis is considered a risk factor for atherosclerosis, but the mechanism not clear. It was reported that oral administration of Porphyromonas gingivalis altered gut microbiota in mice. Gut dysbiosis and intestinal metabolite trimethylamine N-oxide (TMAO) were verified to be associated with atherosclerosis. Therefore, possible TMAO-related between periodontitis atherosclerosis needs explored.Experimental established by P. 2 months ApoE-/- Mouse hemi-mandibles scanned using Micro-CT....
Background Trimethylamine-N-oxide (TMAO) is produced by hepatic flavin-containing monooxygenase 3 (FMO3) from trimethylamine (TMA). High TMAO level a biomarker of cardiovascular diseases and metabolic disorders, it also affects periodontitis through interactions with the gastrointestinal microbiome. While recent findings indicate that may alter systemic levels, specific mechanisms linking these changes particular oral pathogens require further clarification. Methods In this study, we...
Daunomycin, when conjugated with a targeting antigen by an acid-sensitive spacer, remains inactive at the intravascular p H of 7 but becomes active after cleavage within acidic lysosomal environment target cell. This observation made it possible to construct cytocidal compounds that caused antigen-specific suppression murine lymphocyte function. When daunomycin was coupled hapten conjugate ovalbumin cis -aconityl group, hapten-specific impairment immunocompetence in B lymphocytes vitro and...
Abstract Heme oxygenase-1 (HO-1), a stress-inducible protein with potential anti-inflammatory effect, plays an important role in skin injury and wound healing. However, the function of HO-1 cutaneous inflammatory diseases, such as psoriasis, remains unknown. The abnormal activation Stat3, known transcription factor that induces inflammation regulates cell differentiation, is directly involved pathogenesis development psoriasis. Hence, targeting Stat3 potentially beneficial treatment In this...
Abstract We aimed to design a novel three-dimensional (3D) printed surgical guide and evaluate its accuracy in assisting endodontic microsurgeries. A new 3D was designed by computer-aided manufacturing (CAD/CAM) technology applied 7 patients who underwent microsurgeries of upper anterior teeth from 2020.01 2020.12 as the experimental group. suffered operated same surgeon without using 2019.01 2019.12 were selected control Cone beam computed tomography (CBCT) performed more than 12 months...
In this research, a primitive prediction network embedding Spherical Coordinate Transformation (named SCT-Net), which is simple and end-to-end deep neural network, proposed for instance segmentation of point clouds. The key SCT-Net to excavate the relationship between local neighborhood points. First, in order enhance compacted expression feature, spherical coordinate transformation embedded network. Second, constructed predict grouping proposals classify primitives corresponding each...
With the growing concern about human health issues, especially during outbreak of COVID-19 pandemic, demand for personalized healthcare regarding disease prevention and recovery is increasing. However, tremendous challenges lie in both limited public medical resources costly diagnosis approaches. Recently, skin-attachable sensors have emerged as promising monitoring platforms to overcome such difficulties. Owing advantages good comfort high signal-to-noise ratio, enable household, real-time,...
The aim of this study is to treat calcified root canal and assess the accuracy guided endodontics using laser melting templates.Two cases with anterior teeth were treated templates. Cone beam computed tomography (CBCT) was used scan maxillary patients before surgery establish system model. impression patient made it scanned by a 3D scanner. CBCT scans matched surface plaster Mimics 19.0 3-matic 11.0 software design virtual planning access cavities. templates produced printing. Access cavity...
We introduce InvertedFontNet, a pioneering unsupervised font watermarking framework leveraging the style manifold. Previous methodologies typically necessitate manual intervention or are confined by specialized data and media. In contrast, our approach introduces an algorithm that exclusively relies on unlabeled image data, enabling embedding of extensive watermark information across diverse fonts. The strategically modifies spatial structures manipulating manifolds, facilitating watermarks...
Embedding invisible hyperlinks or hidden codes in images to replace QR has become a hot topic recently. This technology requires first localizing the embedded region captured photos before decoding. Existing methods that train models find struggle obtain accurate localization results, leading degraded decoding accuracy. limitation is primarily because CNN network sensitive low-frequency signals, while signal typically high-frequency form. Based on this, this paper proposes Dual-Branch...
Digital watermarking is the process of embedding secret information by altering images in a way that undetectable to human eye. To increase robustness model, many deep learning-based methods use encoder-decoder architecture adding different noises noise layer. The decoder then extracts watermarked from distorted image. However, this method can only resist weak attacks. improve algorithm against stronger noise, paper proposes introduce denoise module between layer and decoder. aimed at...
Human dental pulp stem cells (hDPSCs), which are characterized by self-renewal capacity and the ability of multilineage differentiation, have gained increased attention in regenerative medicine recently. Histone acetylation modulator proteins (HAMPs) a protein family that mediates modification identification histone participates various critical cellular processes. Here, we comprehensively surveyed expression profile HAMPs during osteoblast differentiation hDPSCs found HDAC class III pathway...