A5008088214- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Washington University in St. Louis
2021-2022
Aberrant activation or suppression of WNT/β-catenin signaling contributes to cancer initiation and progression, neurodegeneration, bone disease. However, despite great need more than 40 years research, targeted therapies for the WNT pathway have yet be fully realized. Kinases are considered exceptionally druggable occupy key nodes within network, but several pathway-relevant kinases remain understudied "dark." Here, we studied function casein kinase 1γ (CSNK1γ) subfamily human their roles in...
Abstract The WNT/ β -catenin signaling pathway is evolutionarily conserved and controls normal embryonic development, adult tissue homeostasis regeneration. Aberrant activation or suppression of WNT contributes to cancer initiation progression, developmental disorders, neurodegeneration, bone disease. Despite great need more than 40 years research, targeted therapies for the have yet be fully realized. Kinases are exceptionally druggable occupy key nodes within network, but several...