A5018641106- Human Health and Disease
- Healthcare Systems and Public Health
- Gut microbiota and health
- Diabetes and associated disorders
- Trace Elements in Health
- Pediatric health and respiratory diseases
- Digestive system and related health
- Nutrition, Genetics, and Disease
- Medical and Agricultural Research Studies
- Infant Nutrition and Health
- Clostridium difficile and Clostridium perfringens research
- Immune Response and Inflammation
- Renal function and acid-base balance
- Asthma and respiratory diseases
- Water Resources and Management
- Pneumonia and Respiratory Infections
- Zoonotic diseases and public health
- Microscopic Colitis
- Food Industry and Aquatic Biology
- Environmental Science and Water Management
- Gastroesophageal reflux and treatments
- Medical and Biological Sciences
- Vector-borne infectious diseases
- Neurological Disorders and Treatments
- Circadian rhythm and melatonin
Petrozavodsk State University
2014-2024
Abstract Upregulation of IL-17 immunity and detrimental effects on human islets have been implicated in type 1 diabetes. In animal models, the plasticity Th1/Th17 cells contributes to development autoimmune this study, we demonstrate that upregulation pathway peripheral blood are markers advanced β cell autoimmunity impaired function Activated Th17 was observed late stage preclinical diabetes children with glucose tolerance, but not early autoimmunity. We found an increased ratio IFN-γ/IL-17...
The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in developed world. In order to explore differences gene expression patterns induced utero infants born contrasting standards living hygiene, we collected umbilical cord blood RNA samples from Finland (modern society), Estonia (rapidly developing society) Republic Karelia, Russia (poor economic conditions). whole transcriptome Finnish Estonian neonates differed their Karelian counterparts,...
Rationale. During the COVID-19 pandemic, there was a sharp increase in incidence of community-acquired pneumonia (CAP) Russia and Republic Karelia (RK). Given high significance problem, it is necessary to clarify causes current epidemiological situation. The purpose work : assess CAP, not associated with COVID-19, adult population aged 18 years older 2011–2019 administrative-territorial divisions republic, comparison its existing projected levels 2020–2021. Material method. A retrospective...
Pneumonia remains one of the most pressing problems pulmonology. Despite significant advances in antibacterial and antiviral therapy, mortality from this disease is not going down. Environmental factors play a role development community-acquired pneumonia adults. In northern regions, such as Republic Karelia, environmental conditions unfavorable for human health act risk that contribute to occurrence or worsening disease. The like other territories, has certain characteristics terms content...
The problem of the peptic ulcer disease is one most urgent problems in gastroenterology. In spite modern achievements, this very hard to nurse. article has highlighted results epidemiological research regions European North оf Russia period 2009-2013. analysis data shown that five North, total and primary incidence was above average for Russian Federation. Republic Karelia (RK), Komi Arkhangelsk Region, indicators both general were highest disadvantaged region, where 1.4-1.6-fold higher than...
The problem of the peptic ulcer disease is one most urgent problems in gastroenterology. In spite modern achievements, this very hard to nurse. article has highlighted results epidemiological research regions European North оf Russia period 2009-2013. analysis data shown that five North, total and primary incidence was above average for Russian Federation. Republic Karelia (RK), Komi Arkhangelsk Region, indicators both general were highest disadvantaged region, where 1.4-1.6-fold higher than...
Objective: to estimate the quality of life (QOL) in patients with duodenal ulcers residing North European part Russia and treated by melatonin therapy addition standard anti-ulcer using GSRS questionnaire. Materials methods: study involved 80 uncomplicated ulcer acute stage randomized into 2 groups: group I (n= 40) given three-component treatment (omeprazole, clarithromycin, amoxicillin) (control, n=40) same but without melatonin. Taking account peculiarities photoperiodicity region, 1 was...
Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune-mediated diseases, such allergies asthma. Epithelial surfaces the gastrointestinal respiratory tracts skin constitute primary contact with environmental load.We analyzed levels 30 cytokines growth factors serum or plasma markers immune maturation participants DIABIMMUNE study from Russian Karelia (n = 60), Estonia 83) Finland 89), three neighboring...
Introduction: The Republic of Karelia is a part the Northwestern Federal District and, being sparsely populated constituent entity Russian Federation, characterized by difficult medical and demographic situation. Objective: To assess trends in processes 2011–2021. Materials methods: We analyzed official statistical data provided Territorial Body State Statistics Service for years 2011 to 2021. Both absolute relative values time series indicators were used characterize under study. Results: A...