A5046776994- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Advanced Chemical Physics Studies
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Molecular spectroscopy and chirality
- IL-33, ST2, and ILC Pathways
- Chronic Lymphocytic Leukemia Research
- Pediatric health and respiratory diseases
- Molecular Spectroscopy and Structure
- Inorganic Fluorides and Related Compounds
- Spectroscopy and Quantum Chemical Studies
- Polyomavirus and related diseases
- Chemical Thermodynamics and Molecular Structure
- Atmospheric Ozone and Climate
- Inorganic and Organometallic Chemistry
- Asthma and respiratory diseases
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Ear Surgery and Otitis Media
- Inflammatory Bowel Disease
- Acute Lymphoblastic Leukemia research
- Protein Structure and Dynamics
- Psoriasis: Treatment and Pathogenesis
- Chronic Myeloid Leukemia Treatments
University of Helsinki
2000-2025
Helsinki University Hospital
2002-2025
Finnish Red Cross
2024
Finnish Food Authority
2021
Children's Hospital
2017
Finnish Institute for Health and Welfare
2010-2015
National Institutes of Health
2013-2015
University of Eastern Finland
2006
St Petersburg University
1995
Institute of Physics
1995
Abstract Th17 immunity has been shown to regulate autoimmune diabetes in mice. IL-17 neutralization prevented development of when given postinitiation insulitis but not earlier, suggesting interference with the effector phase disease. Islet-cell Ag-specific cells converted into IFN-γ–secreting Th1-like and caused mice recipients. The role human type 1 (T1D) is, however, established. In this study, we show upregulation peripheral blood T from children T1D. This was characterized by increased...
Abstract Upregulation of IL-17 immunity and detrimental effects on human islets have been implicated in type 1 diabetes. In animal models, the plasticity Th1/Th17 cells contributes to development autoimmune this study, we demonstrate that upregulation pathway peripheral blood are markers advanced β cell autoimmunity impaired function Activated Th17 was observed late stage preclinical diabetes children with glucose tolerance, but not early autoimmunity. We found an increased ratio IFN-γ/IL-17...
Ultraviolet (UV) irradiation of HI-doped xenon matrix dissociates the precursor and leads to formation trapping neutral atoms. After UV photolysis, annealing mobilizes hydrogen atoms at about 38 K. The mobilized react with I/Xe centers forming HXeI molecules in a diffusion controlled reaction. formed can be photolyzed infrared (IR) 2950–3800 cm−1 quantitatively regenerated thermally. from is proved by quantitative correlation between iodine selective IR photodissociation thermal regeneration...
Recent studies suggest that the cross talk between gut microbiota and human immune system during first year of life is an important regulator later development atopic diseases. We explored dynamic changes in blood regulatory T cells, emergence sensitization a birth-cohort Estonian Finnish children followed from 3 to 36 months age. describe here infant Treg phenotype characterized by high frequency, maturation population with decreasing frequency accompanied increase highly activated cells....
Occurrence and distribution of perfluoroalkyl acids (PFAAs), a sub-category per- polyfluoroalkyl substances (PFASs), is widespread in the environment. Food, especially fish meat, major pathway via which humans are exposed to PFAAs. As an integral part Nordic diet, therefore, this study, several species, caught selected Baltic Sea basins freshwater bodies Finland, were analysed for Perfluorooctane sulfonate (PFOS) was detected all samples >80% from freshwaters. PFOS contributed between 46...
Epstein-Barr virus (EBV) infection is a major risk factor of multiple sclerosis (MS). We examined the presence EBV DNA in CSF and blood patients with MS controls. analyzed whether more common than controls estimated proportions EBV-positive B cells blood.
The results of a combined vibrational and structural study the acrylic acid monomer undertaken by matrix-isolated low-temperature IR spectroscopy ab initio SCF-HF MP2 MO calculations are presented. In addition, both Raman spectra liquid spectrum crystal also reported interpreted. It is shown that in argon krypton matrices exists as mixture two conformers similar energies, differing relative orientation CC—CO axis. Upon irradiation at λ= 243 nm xenon lamp, s-cis form (CC—CO dihedral angle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMatrix-isolation and ab initio studies of oxalic acidJ. Nieminen, M. Rasanen, J. MurtoCite this: Phys. Chem. 1992, 96, 13, 5303–5308Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/j100192a024https://doi.org/10.1021/j100192a024research-articleACS PublicationsRequest reuse permissionsArticle Views356Altmetric-Citations63LEARN ABOUT THESE METRICSArticle...
The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in developed world. In order to explore differences gene expression patterns induced utero infants born contrasting standards living hygiene, we collected umbilical cord blood RNA samples from Finland (modern society), Estonia (rapidly developing society) Republic Karelia, Russia (poor economic conditions). whole transcriptome Finnish Estonian neonates differed their Karelian counterparts,...
Background Predisposition to childhood otitis media (OM) has a strong genetic component, with polymorphisms in innate immunity genes suspected contribute risk. Studies on several have been conducted, but most associations failed replicate independent cohorts. Methods We investigated 53 gene Finnish cohort of 624 cases and 778 controls. A positive association signal was followed up tagging approach tested an 205 cases, British 1269 trios, as well two cohorts from the United States (US); one...
Background. Classic Kaposi sarcoma (cKS) is an inflammatory tumor caused by human herpesvirus 8 (HHV-8) commonly observed in elderly men of Mediterranean origin. We studied a Finnish family 5 affected individuals 2 generations. Except for atypical mycobacterial infection the index case, did not have notable histories infection.
ABSTRACT Background Surgical nerve injuries lead to persistent neuropathic pain (NP) in up 30% of patients. Among many other factors, polymorphisms the human leukocyte antigen (HLA) genes have been suggested contribute development pain. Methods We performed a genetic association analysis HLA class I and II alleles women who had operated on for breast cancer. Patients surgeon‐confirmed perioperative injury were examined 4–9 years after their surgery. with painful (cases, n = 27) painless...
Dendritic cells (DCs) are largely responsible for the activation and fine-tuning of T-cell responses. Altered numbers blood DCs have been reported in type 1 diabetes (T1D). We aimed at characterizing less well-known phenotypic properties T1D.In a case-control setting, samples from total 90 children were studied by flow cytometry or quantitative real-time PCR (qPCR).We found decreased myeloid (mDCs) (8.97 vs. 13.4 cells/μL, P = 0.009, n 31) plasmacytoid (pDCs) (9.47 14.6 0.018, 30)...
A high-fat diet promotes postprandial systemic inflammation and metabolic endotoxemia. We investigated the effects of three consecutive meals on endotoxemia, inflammation, vascular function, lipid metabolism in patients with type 1 diabetes.Non-diabetic controls (n = 34) diabetes 37) were given high-caloric, fat-containing during one day. Blood samples drawn at fasting (8:00) every two hours thereafter until 18:00. Applanation tonometry was used to assess changes augmentation index...
Abnormalities of dendritic cells (DCs) and STAT proteins have been reported in Crohn's disease (CD). Studies on JAK/STAT signaling DCs are, however, lacking CD. We applied a flowcytometric single-cell-based phosphoepitope assay to evaluate STAT1 STAT3 pathways DC subsets from CD patients. In addition, circulating counts were determined, together with the activation-related immunophenotype. found that IL-6- IFN-α-induced phosphorylation impaired plasmacytoid (pDCs) patients (P = 0.005, P...
Abstract Farm environment has been shown to protect from childhood asthma. Underlying immunological mechanisms are not clear yet, including the role of dendritic cells ( DC s). The aim was explore whether asthma and farm exposures associated with proportions functional properties s 4.5‐year‐old children in a subgroup Finnish PASTURE birth cohort study. Myeloid mDC s), plasmacytoid pDC s) CD 86 expression on ex vivo n = 100) identified peripheral blood mononuclear PBMC were analysed using...
Optic neuritis (ON) can occur as an isolated episode or will develop to multiple sclerosis (MS) a chronic autoimmune disease. What predicts ON progression MS remains poorly understood. We characterised the antibody epitope repertoire in three independent clinical cohorts (discovery (n = 62), validation 20) and external cohort 421)) using mimotope variation analysis (MVA), next generation phage display technology identify epitopes that associate with prognosis of ON. observed distinct...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe ClOClO, BrOClO, and IOClO Molecules Their Photoisomerization. A Matrix Isolation StudyKlas Johnsson, Anders Engdahl, Jennifer Koelm, Janne Nieminen, Bengt NelanderCite this: J. Phys. Chem. 1995, 99, 12, 3902–3904Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/j100012a006https://doi.org/10.1021/j100012a006research-articleACS PublicationsRequest...
Reduced risk for type 1 diabetes (T1D) has been reported in the offspring of mothers with T1D when compared children affected fathers.
An analytical potential energy surface (PES) along the stretching coordinates of a linear XeHXe+ ion is presented. Ab initio calculations within effective core approach are used as input for PES. The present vibrational analysis indicates extensive mixing zeroth-order harmonic oscillator states, and rather complete collapse normal mode picture already near bottom well. At higher energies, elongated Xe–Xe distances, development double minimum in PES observed. simulated absorption spectrum...