A5048745973- Ion Transport and Channel Regulation
- Glaucoma and retinal disorders
- Biofuel production and bioconversion
- Connexins and lens biology
- Retinal Development and Disorders
- Enzyme Production and Characterization
- Ion channel regulation and function
- Polysaccharides and Plant Cell Walls
- Retinal Imaging and Analysis
- Enzyme Structure and Function
- Electrolyte and hormonal disorders
- Amino Acid Enzymes and Metabolism
- Retinal Diseases and Treatments
- Privacy-Preserving Technologies in Data
- Photoreceptor and optogenetics research
- Mechanical Engineering and Vibrations Research
- Microbial Metabolites in Food Biotechnology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- RNA and protein synthesis mechanisms
- Neonatal Respiratory Health Research
- IoT and Edge/Fog Computing
- Retinal and Optic Conditions
- Blockchain Technology Applications and Security
- Magnesium in Health and Disease
- Advanced Machining and Optimization Techniques
GITAM University
2023-2025
MIT Art, Design and Technology University
2022-2024
University of Agricultural Sciences, Dharwad
2019-2023
Smt. Kashibai Navale Medical College and General hospital
2020-2021
Savitribai Phule Pune University
2020-2021
Andover Eye Associates
2020
Singapore Eye Research Institute
2017-2018
Mahatma Gandhi Medical College and Research Institute
2018
Duke-NUS Medical School
2017
Singapore National Eye Center
2017
Glaucomatous optic neuropathy causes blindness through the degeneration of retinal ganglion cells (RGCs) and their axons, which comprise nerve. Glaucoma traditionally is associated with elevated intraocular pressure, but often occurs or may progress pressure in normal range. Like other diseases CNS, a subset glaucoma has been proposed to involve an autoimmune component help explain loss RGCs absence pressure. One hypothesis involves heat shock proteins (HSPs), because increased serum levels...
The 987-base-pair coding region of the tdc gene Escherichia coli K-12 encoding biodegradative threonine dehydratase [Tdc; L-threonine hydro-lyase (deaminating), EC 4.2.1.16], previously cloned in this laboratory, was sequenced. deduced polypeptide consists 329 amino acid residues with a calculated Mr 35,238. Although purified enzyme shown to contain tryptophan, no tryptophan codon found reading frame. Incubation Tdc [14C]tryptophan revealed apparent "covalent" binding indicating...
Purpose Bioprinting is a promising technology, which has gained recent attention, for application in all aspects of human life and specific advantages different areas medicines, especially ophthalmology. The three-dimensional (3D) printing tools have been widely used applications, from surgical planning procedures to 3D models certain highly delicate organs (such as: eye heart). purpose this paper review the dedicated research efforts that so far made highlight applications field...
Idiopathic infantile nystagmus (IIN) is a genetically heterogeneous disorder of eye movement that can be caused by mutations in the FRMD7 gene encodes FERM domain protein. expressed brain and knock-down studies suggest it plays role neurite extension through modulation actin cytoskeleton, yet little known about its precise molecular function effects IIN mutations. Here, we studied four IIN-associated missense mutants found them to have diverse on expression cytoplasmic localization. The...
Interleukin (IL)-10 has recently been shown to promote survival of neurons and glia. The purpose this report is investigate whether IL-10 any role in protecting retinal ganglion cells (RGCs) from death under conditions which growth factors are removed, or oxidative stress present. Signal transduction pathways that activate signaling RGCs were studied both conditions.Effects various interleukins on the viability RGC cell line was determined, apoptotic quantified. Immunoblot analysis preformed...
Preservation of data privacy in cloud computing involves securing sensitive during analysis and storage. Conventional approaches often use techniques such as encryption differential privacy, but they can be computationally intensive may still risk leakage through indirect inferences. These limitations necessitate advanced methods to balance efficiency robust privacy. To address this, this study proposes a novel approach using DL-based fine-tuned keys for encrypting the data, aimed at...
Aquaporins (AQPs) are a family of membrane proteins that function as channels facilitating water transport in response to osmotic gradients. These play critical roles several normal physiological and pathological states targets for drug discovery. Selective inhibition the AQP1 channel may provide new approach treatment disorders including ocular hypertension/glaucoma, congestive heart failure, brain swelling associated with stroke, corneal macular edema, pulmonary otic such hearing loss...
Summary: An extracellular cellobiose dehydrogenase has been purified from the culture filtrates of Sclerotium rolfsii. The enzyme is homogeneous as determined by disc gel electrophoresis, with and without SDS, analytical isoelectric focusing in polyacrylamide gel. a single-subunit glycoprotein containing 8·9% total carbohydrate; its M r 63000-64500, point 5·18. oxidized cellobiose, other cellodextrins lactose whereas disaccharides tested were not utilized substrates. rate cellodextrin...
Journal Article PCR amplification of an Escherichia coli gene using mixed primers containing deoxyinosine at ambiguous positions in degenerate amino acid codons Get access Rajkumar V. Patil, Patil Department Biological Chemistry, University MichiganAnn Arbor, MI 48109–0606, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Eugene E. Dekker * To whom correspondence should be addressed Nucleic Acids Research, Volume 18, Issue 10, 25 May 1990, Page 3080,...
Neovascular age-related macular degeneration (AMD) is treated with anti-VEGF intravitreal injections, which can cause geographic atrophy, infection, and retinal fibrosis. To minimize these toxicities, we developed a nanoparticle delivery system for recombinant Flt23k intraceptor plasmid (RGD.Flt23k.NP) to suppress VEGF intracellularly within choroidal neovascular (CNV) lesions in laser-induced CNV mouse model through intravenous administration. In the current study, examined efficacy safety...
Elevated cAMP in the trabecular meshwork (TM) cells increases aqueous humor outflow facility. The authors investigated mechanisms by which elevated opposes RhoA-Rho kinase pathway, leading to relaxation of actomyosin system bovine TM cells.Forskolin (Fsk) and rolipram were used elevate levels. Changes phosphorylation RhoA at Ser188 (a putative inhibitory site), regulatory light chain myosin (pMLC), subunit phosphatase (MYPT1) determined Western blot analysis. contraction was measured...
Aquaporin-4 (AQP4) is a basolateral water channel in collecting duct principal cells and assembles into orthogonal array particles (OAPs), the size of which appears to depend on relative expression levels AQP4 splice variants. Because higher-order organization was perturbed by vasopressin Brattleboro rats phosphorylation sites have been identified AQP4, we investigated whether forskolin (Fk) affect assembly and/or LLC-PK(1) stably transfected with variant M23, responsible for formation OAPs,...