Objective: To determine the effect of single dose administration dexamethasone on post-operative pain in patients undergoing laparoscopic cholecystectomy. Methodology: This randomized control trial was conducted at PAF Hospital Islamabad from January 2023 till June 2023. Ninety-two both genders underwent cholecystectomy and were randomly assigned to two groups. Group A given 8 mg (dissolved 100ml 0.9% isotonic normal saline) intravenously 30 minutes before induction anaesthesia (n=46). B...

Objectives: The purpose of this study was to establish the prevalence hyponatremia among children 2 months 5 years age admitted at Ayub Teaching Hospital, Abbottabad, with pneumonia and factors related it. Materials Methods: An analytical cross-sectional conducted in pediatric department on 135 pneumonia. level determined by patient’s serum sodium concentration <135mEq/L, moderate 131-134mEq/L, severe 126-130mEq/L, 125mEq/L. socio-demographic profile children, severity pneumonia, data...

The current study is aimed to fabricate doxorubicin (Dox) loaded mild temperature responsive liposomes (MTLs) by thin film hydration technique for enhanced in vitro and vivo anticancer efficacy against hepatocellular carcinoma. aforementioned Dox MTLs were developed optimized with extrusion drug loading techniques. optimum size range (118.20 ± 2.81–187.13 4.15 nm), colloidal stability (−13.27 0.04 −32.34 0.15 mV), entrapment of (28.71 2.01–79.24 2.16). Furthermore, the formulation...

Sesuvium sesuvioides (Fenzl) Verdc (Aizoaceae) has been traditionally used in the treatment of inflammation, arthritis, and gout. However, its antiarthritic potential not evaluated scientifically. The current study was designed to assess properties n -butanol fraction S. (SsBu) by phytochemical analysis, vitro vivo pharmacological activities, silico studies. Phytochemical analysis showed total phenolic contents (90.7 ± 3.02 mg GAE/g) flavonoid (23.7 0.69 RE/g), further GC-MS identified...

Abstract Short Synacthen test (SST) involves measuring the baseline, 30-, and 60-minute serum cortisol levels, after injecting 250 μg of synthetic adrenocorticotropic hormone or (ACTH). This study aimed to review current clinical practice performing SST establish a standardized protocol additionally hypothesis regarding alone dependence overall result on baseline level. Patients >14 years who underwent from January 2010 December 2017 were included. Pearson's chi-square cross-tabulation...

Introduction Among all benign conditions, the fibroadenoma is most common lesion worldwide as well in Pakistan. Clinicians often face dilemma of whether to remove mass or monitor it by means periodic follow-up examinations. Although removal these lesions a definitive solution, surgery may involve unnecessary excision and unbecoming cosmesis. Body index (BMI) known risk factor for development breast cancer.However, relationship between BMI diseases still unclear. Some studies showed that...

Sesuvium sesuvioides was used to treat inflammation, arthritis, gout, and thyroid dysfunction. The current study evaluated the antihyperthyroidism effect of S. consolidate its traditional use. High-performance liquid chromatography (HPLC) analysis methanol extract revealed presence phenolics such as gallic acid (0.73 ppm/mg), benzoic (11.22 p-coumaric (3.12 ferulic (5.47 cinnamic (3.54 sinapic (3.17 ppm/mg). In vivo hyperthyroidism induced using thyroxine in vivo, which increased T3...

The study was designed to investigate the antithyroid activity of crude methanolic (70%) extract aerial parts Abutilon indicum in male albino rats. prepared and analyzed for presence phytochemical constituents through preliminary chemical analysis, antioxidant assay GC-MS. vivo activities thyroxine-induced hyperthyroidism were studied. Phytochemical analysis showed alkaloids, flavonoids phenols, also verified by data obtained from Thyroxine increased levels triiodothyronine (4.9 ± 0.1 ng/mL)...

Laparoscopic sleeve gastrectomy (LSG) is one of the world's most commonly performed types bariatric surgery. Routine histopathology surgical specimen undertaken at institutions, regardless lack clinical suspicion any sinister pathology. We evaluated reports LSG cases done for morbid obesity our hospital over 10 years to determine distribution gastric changes and prevalence

The orthotopic ileal neobladder is becoming a popular technique of urinary diversion after radical cystectomy (RC) for localized muscle-invasive bladder cancer (MIBC), allowing patient continence, with more desirable body image and good quality life. Minimally invasive robot-assisted RC have the potential to minimize physical psychological trauma are increasingly being adopted patients MIBC worldwide. Spontaneous perforation uncommon;however, it represents serious complications. Solitary...

Abstract: Background: Sleeve gastrectomy is the common bariatric procedure done for morbid obesity, but there are limited studies available, specifically from South Asia. In Pakistan, no such study has been before. Objective: The main outcome of was Excess weight loss (EWL) and Weight Regain (WR) after Laparoscopic sleeve to see improvement in co-morbid associated with obesity. Materials Methods: patients who underwent obesity were analyzed retrospectively. From June 2017 2019, a tertiary...

Operative management of all gunshot's traumas carries a high rate unwarranted interventions that are known to cause serious complications. Selective nonoperative is thus being increasingly practiced which has reduced these avoidable interventions. Physical examination and computed tomography scans most sensitive in assessing need laparotomy. Assessment internal injuries on the basis an estimated bullet trajectory often but seldom been studied. We report case conservative thoraco abdominal...

Background: Diabetes is a chronic disease that affects millions of people. Depression reported to be common comorbidity in diabetic patients. patients associated with worse glycemic control, and increased risk diabetes complications, including cardiovascular disease, neuropathy, retinopathy Study design: It cross-sectional study conducted at Department Medicine, Amna Inayat Medical College, Lahore for the duration six months from April 2022 September 2022. Material Methods: The included 150...

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, is a of chronic inflammatory conditions the intestinal tract due to disturbance inflammation immune system. Symptoms IBD include abdominal pain, diarrhea, bleeding, reduced weight, fatigue. In IBD, system attacks tract's inner wall, causing tissue damage. particular, IL-6 IL-17 act on cells, T cells macrophages, amplify responses so that damage morphological changes occur. Of note,...

Background: The measles is an extremely infectious viral exanthema, caused by Morbilivirus belonging to the family Paramyxoviridae. Prior introduction of vaccine, disease millions fatalities annually around globe. Objective: To determine Prevalence Immunization Status, Complications and Outcome in Children Admitted with Measles tertiary care hospital Methodology: This cross sectional study was conducted at department Pediatrics, Combined Military Hospital, Abbottabad - Pakistan. duration six...

Introduction: Obesity is a chronic disease that can be effectively managed with bariatric surgery, such as gastric bypass. Both Roux-en-Y bypass (RYGB) and one-anastomosis (OAGB) surgeries are associated malnutrition. OAGB higher weight loss remission of diabetes. However, it also significantly greater incidence malnutrition than RYGB. We conducted this study to assess the association both procedures different micronutrient deficiencies. Methods: A retrospective single-center cohort was...