A5041600814- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Anesthesia and Neurotoxicity Research
- Acute Ischemic Stroke Management
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Abdominal vascular conditions and treatments
- Poisoning and overdose treatments
- Nosocomial Infections in ICU
- Vitamin D Research Studies
- Male Breast Health Studies
- Sepsis Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Healthcare Decision-Making and Restraints
- Intracranial Aneurysms: Treatment and Complications
- Kawasaki Disease and Coronary Complications
- Breast Lesions and Carcinomas
- Microscopic Colitis
- Venous Thromboembolism Diagnosis and Management
- Phytochemistry and Biological Activities
- Intestinal and Peritoneal Adhesions
- Cancer Risks and Factors
- Thyroid and Parathyroid Surgery
- Gastrointestinal disorders and treatments
National Institute of Cardiovascular Diseases
2024
Broward Health Medical Center
2023
University of Pennsylvania
2017-2022
Regional Medical Center
2021
Hurley Medical Center
2007-2021
Michigan State University
2019-2021
University of Minnesota
2021
Valley Medical Center
2021
University of Washington
2021
University of Maryland Medical Center
2019-2020
BACKGROUND Traumatic brain injury (TBI) is accompanied by a hyperadrenergic catecholamine state that can cause penumbral neuroinflammation. Prospective human studies demonstrate improved TBI survival with beta blockade (bb), although mechanisms remain unclear. We hypothesized deranged post-TBI blood barrier (BBB) leukocyte mobilization and permeability are bb. METHODS CD1 male mice (n = 64) were randomly assigned to severe TBI—controlled cortical impact: 6 m/s velocity, 1 mm depth, 3...
Brain injury progression after severe traumatic brain (TBI) is associated with worsening cerebral inflammation but it unknown how a concomitant bone fracture (BF) affects this progression. Enoxaparin (ENX) decreases penumbral leukocyte mobilization TBI and improves neurologic recovery. We hypothesized that BF worsens learning/memory recovery weeks ENX recovery.CD1 male mice underwent controlled cortical impact or sham craniotomy without tibial fracture, receiving either daily (0.8 mg/kg)...
Severe traumatic brain injury (TBI) patients are at high risk for early aspiration and pneumonia. How pneumonia impacts neurological recovery after TBI is not well characterized. We hypothesized that, independent of the cerebral injury, delays worsens cognitive outcomes.Fifteen CD1 male mice were randomized to sham craniotomy or severe (controlled cortical impact [CCI] - velocity 6 m/s, depth 1.0 mm) ± intratracheal lipopolysaccharide (LPS-2 mg/kg in 0.1 mL saline) as a bioeffector....
Acute traumatic coagulopathy often accompanies brain injury (TBI) and may impair cognitive recovery. Antithrombin III (AT-III) reduces the hypercoagulability of TBI. heparinoids such as enoxaparin (ENX) demonstrate potent anti-inflammatory activity, reducing organ modulating leukocyte (LEU) activation, independent their anticoagulant effect. It is unknown what impact AT-III exerts on cerebral LEU activation blood-brain barrier (BBB) permeability after We hypothesized that live...
Introduction Among all benign conditions, the fibroadenoma is most common lesion worldwide as well in Pakistan. Clinicians often face dilemma of whether to remove mass or monitor it by means periodic follow-up examinations. Although removal these lesions a definitive solution, surgery may involve unnecessary excision and unbecoming cosmesis. Body index (BMI) known risk factor for development breast cancer.However, relationship between BMI diseases still unclear. Some studies showed that...
Progression of severe traumatic brain injury (TBI) is associated with worsening cerebral inflammation, but it unknown how a concomitant bone fracture (FX) affects this progression. Enoxaparin (ENX), low molecular weight heparin often used for venous thromboembolic prophylaxis, decreases penumbral leukocyte (LEU) mobilization in isolated TBI and improves neurological recovery. We investigated if accompanied by an FX worsens LEU-mediated inflammation ENX alters process. CD1 male mice underwent...
BACKGROUND Neuroinflammation and cerebral edema development following severe traumatic brain injury (TBI) affect subsequent cognitive recovery. Independent of its anticoagulant effects, antithrombin III (AT-III) has been shown to block neurovascular inflammation after TBI, reduce endothelial-leukocyte interactions, decrease blood-brain barrier permeability. We hypothesized that AT-III administration TBI would improve post-TBI recovery, specifically enhancing learning, memory. METHODS Fifteen...
CASE EXAMPLE A 38-year-old woman with a past medical history of anxiety, depression, and attention deficit disorder presented to free-standing emergency department (FSED) palpitations globus sensation, following unsupervised cessation vilazodone phentermine for 3 days. Symptoms were similar the patient's previous panic attacks. The patient started experiencing severe symptoms 2 h before FSED arrival. She was routed (ED) acute anxiety treatment by her primary care physician (PCP). Her vital...
This case report documents the clinical journey of a 22-year-old male who was initially diagnosed with Rheumatoid Arthritis (RA) and later, at age 11, Juvenile Idiopathic (JIA). The patient manifested atypical symptoms, primarily marked by sudden intense chest pain accompanied sweating, leading to collapse during his emergency room visit. Medical evaluation revealed an extensive myocardial infarction affecting anterior wall. underwent successful percutaneous coronary intervention targeting...
Simple, isolated nonspecific colonic ulcer (NSCU) is a rare pathological entity which has not been adequately explored in the past literature. It predominant between ages of 40 and 60 years, most common complication perforation can be life threatening. Here we present case young female who presented with perforated NSCU was successfully managed surgically.
Ischemic colitis is typically considered a disease of the elderly, given their atherosclerotic risk factors and other comorbidities. in younger population very uncommon. We present an interesting case young female presenting with abdominal pain hematochezia found to have ischemic on pathological biopsy results after colonoscopy. She was otherwise healthy no medical problems prior her hospitalization but endorsed recent use bitter herbal tea relieve symptoms. Here, we review potential causes...
Ahmed, Syed; Suto, Yujin; Jacovides, Christina; Nagata, Katsuhiro; Cognetti, John; Browne, Kevin; Weber, Maura; Johnson, Victoria; Leone, Ryan; Kaplan, Lewis; Smith, Douglas; Pascual, Jose Author Information
A 64-year-old African American male, with past medical history of hypertension, depression, and seizure disorder, presented an episode generalized tonic-clonic seizure. He was treated for seizures, after 48 hours seizure-free, the patient started complaining chest tightness troponin levels were found to be 34.71 ng/mL. No evidence myocardial infarction extensive diagnostic workup, including cardiac catheterization. We suspect alternative causes elevated post-seizure transient takosubo cardiomyopathy.