A5051869692- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Electrolyte and hormonal disorders
- Hepatitis Viruses Studies and Epidemiology
- Liver physiology and pathology
- Pancreatic function and diabetes
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal function and acid-base balance
- Renal Transplantation Outcomes and Treatments
- HIV/AIDS drug development and treatment
- Folate and B Vitamins Research
- Liver Diseases and Immunity
- Dialysis and Renal Disease Management
- Drug-Induced Hepatotoxicity and Protection
- Abdominal vascular conditions and treatments
- Oral and gingival health research
- Vaccine Coverage and Hesitancy
- Porphyrin Metabolism and Disorders
- Sepsis Diagnosis and Treatment
- Platelet Disorders and Treatments
- HIV/AIDS Research and Interventions
- Pediatric Hepatobiliary Diseases and Treatments
Albert Einstein College of Medicine
1994-2024
Montefiore Medical Center
2016-2024
University of Oxford
2024
Long Island University
2024
Yeshiva University
2021
Hadassah Medical Center
2021
Hebrew University of Jerusalem
2021
New York University
2010-2017
NYU Langone Health
2012-2016
UCLA Health
2016
Hepatic encephalopathy is a chronically debilitating complication of hepatic cirrhosis. The efficacy rifaximin, minimally absorbed antibiotic, well documented in the treatment acute encephalopathy, but its for prevention disease has not been established.In this randomized, double-blind, placebo-controlled trial, we randomly assigned 299 patients who were remission from recurrent resulting chronic liver to receive either at dose 550 mg twice daily (140 patients), or placebo (159 patients) 6...
The interferon-free combination of the protease inhibitor ABT-450 with ritonavir (ABT-450/r) and NS5A ombitasvir (also known as ABT-267) plus nonnucleoside polymerase dasabuvir ABT-333) ribavirin has shown efficacy against hepatitis C virus (HCV) in patients HCV genotype 1 infection. In this phase 3 trial, we evaluated regimen previously untreated infection no cirrhosis.
Eltrombopag is a new, orally active thrombopoietin-receptor agonist that stimulates thrombopoiesis. We evaluated its ability to increase platelet counts and facilitate treatment for hepatitis C virus (HCV) infection in patients with thrombocytopenia associated HCV-related cirrhosis.Seventy-four cirrhosis of 20,000 less than 70,000 per cubic millimeter were randomly assigned receive eltrombopag (30, 50, or 75 mg daily) placebo daily 4 weeks. The primary end point was count 100,000 more at...
In understanding mechanisms of liver repopulation with transplanted hepatocytes, we studied the consequences hepatic polyploidization in two-thirds partial hepatectomy model regeneration. Liver studies using genetically marked rodent hepatocytes showed that number previously did not increase subsequential hepatectomy. contrast, recipients undergoing before cells were proliferation kinetics DNA synthesis differing and host hepatocytes. Also, caused multiple changes rat liver, including...
Current management practices for hyponatremia (HN) are incompletely understood. The HN Registry has recorded diagnostic measures, utilization, efficacy, and outcomes of therapy eu- or hypervolemic HN. To better understand current practices, we analyzed data from 3087 adjudicated adult patients in the registry with serum sodium concentration 130 mEq/l less 225 sites United States European Union. Common initial monotherapy treatments were fluid restriction (35%), administration isotonic (15%)...
Glycerol phenylbutyrate (GPB) lowers ammonia by providing an alternate pathway to urea for waste nitrogen excretion in the form of phenylacetyl glutamine, which is excreted urine. This randomized, double-blind, placebo-controlled phase II trial enrolled 178 patients with cirrhosis, including 59 already taking rifaximin, who had experienced two or more hepatic encephalopathy (HE) events previous 6 months. The primary endpoint was proportion HE events. Other endpoints included time first...
The development of hepatorenal syndrome type 1 (HRS1) is associated with a poor prognosis. Liver transplantation improves this prognosis, but the degree improvement unclear. Most patients receive vasoconstrictors such as terlipressin before transplantation, and may affect posttransplant outcomes. We examined cohort access to liver from our previously published study plus albumin versus alone in treatment HRS1. purpose analysis was quantification survival benefits for Ninety-nine were...
Data on acute variceal hemorrhage (AVH) in the United States is limited and best method to stratify risk not clear. Taking advantage of a prospective US cohort study, we aimed (1) describe clinical outcomes AVH their predictors; (2) compare predictors 6-week mortality.Prospective 15-center patients with cirrhosis presenting endoscopically proven AVH, all whom received antibiotics, vapreotide (a somatostain analog) infusion endoscopic band ligation. Patients were enrolled between August 2006...
Background. Chronic hepatitis C infection is prevalent among haemodialysis patients. The goal of our study was to determine the efficacy and safety pegylated interferon α-2b in patients with chronic C.
The purpose of this study was to estimate perfusion metrics in healthy and cirrhotic liver with pharmacokinetic modeling high-temporal resolution reconstruction continuously acquired free-breathing gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced acquisition patients undergoing clinically indicated magnetic resonance imaging.In Health Insurance Portability Accountability Act-compliant prospective study, 9 10 noncirrhotic underwent clinical imaging, which included radial...
PURPOSE Lactate is an established prognosticator in critical care. However, there still insufficient evidence about its role predicting outcome COVID-19. This of particular concern older patients who have been mostly affected during the initial surge 2020. METHODS This prospective international observation study (The COVIP study) recruited aged 70 years or (ClinicalTrials.gov ID: NCT04321265) admitted to intensive care unit (ICU) with COVID-19 disease from March 2020 February 2021....
An increased ammonia level of gut bacterial origin is an important mediator in the pathogenesis hepatic encephalopathy (HE), and constipation a frequent precipitant coma. Because diabetes mellitus (DM) may be associated with delayed gastrointestinal transit, we speculated that its presence patients HCV-related cirrhosis would predispose to exacerbate HE.Sixty-five (50 men, 15 women) attending liver transplantation clinic were assessed for severity disease DM cross-sectional study. A modified...
Rectal mucosal biopsy specimens from 75 human immunodeficiency virus (HIV)-seropositive and 16 HIV-seronegative subjects were examined. The histopathologic changes correlated with immunoperoxidase staining for UCHL-1 HIV core protein p24, quantitative p24 enzyme-linked immunosorbent assay (ELISA) in homogenized rectal tissue serum, a modified Walter Reed clinical stage. Four phases seen the HIV-infected subjects: (1) early phase, stage 1-2 subjects, nearly normal histology low p24; (2)...
Cirrhosis resulting from hepatitis C virus is presently the most common indication for liver transplantation (OLT) in United States. A number of U.S. transplant centers require cirrhotics who are using methadone to discontinue it before proceeding with OLT. We sought examine outcomes those patients had undergone OLT at Mount Sinai Medical Center. retrospective chart review 36 subjects on maintenance treatment (MMT), and off heroin, time was performed. The median daily dose pre-OLT 50 mg....