A5061138871- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Maritime Navigation and Safety
- Organ Transplantation Techniques and Outcomes
- Neurological Complications and Syndromes
- Inertial Sensor and Navigation
- Transplantation: Methods and Outcomes
- GNSS positioning and interference
- Pharmacological Effects and Toxicity Studies
- Dialysis and Renal Disease Management
- Cytomegalovirus and herpesvirus research
- Complement system in diseases
- Gene Regulatory Network Analysis
- COVID-19 Clinical Research Studies
- Renal and Vascular Pathologies
- Pregnancy and Medication Impact
- Construction Engineering and Safety
- SARS-CoV-2 and COVID-19 Research
- Remote Sensing and LiDAR Applications
- Parvovirus B19 Infection Studies
- Adenosine and Purinergic Signaling
- Underwater Vehicles and Communication Systems
- Single-cell and spatial transcriptomics
- BIM and Construction Integration
- Geophysics and Gravity Measurements
Medical University of South Carolina
2020-2024
University of Southampton
2019-2023
Health Resources and Services Administration
2023
Patient-Centered Outcomes Research Institute
2023
National Institute of Diabetes and Digestive and Kidney Diseases
2023
Beth Israel Deaconess Medical Center
2023
University of South Carolina
2023
University of Siena
2021
George Mason University
2008-2020
Pennsylvania State University
2020
ABSTRACT wingless/wnt-1 signaling directs cell fate during development. Genetic analysis in Drosophila identified genes that may encode components of the wingless signal transduction system. Armadillo, homolog vertebrate β-catenin, is required for signaling. Unlike armadillo RNA, Armadillo protein accumulates non-uniformly different cells each embryonic segment. We found alter their intracellular distribution response to Wingless signal, accumulating increased levels cytoplasmic relative...
The Glasgow Coma Scale (GCS) is widely applied in the emergency setting; it used to guide trauma triage and for application of essential interventions such as endotracheal intubation. However, inter-rater reliability GCS scoring has been shown be low inexperienced users, especially motor component. Concerns regarding accuracy validity between various types care providers have expressed. Hypothesis/Problem objective this study was determine degree within a modern Emergency Medical Services...
Abstract Emerging bacterial pathogens threaten global health and food security, so it is important to ask whether these transitions pathogenicity have any common features. We present a systematic study of the claim that associated with genome reduction gene loss. compare broad-scale patterns across all bacteria, detailed analyses Streptococcus suis, an emerging zoonotic pathogen pigs, which has undergone multiple between disease carriage forms. find consistently reduced size three scales...
Background When kidney transplants fail, transplant medications are discontinued to reduce immunosuppression-related risks. However, retransplant candidates at risk for allosensitization which prolonging immunosuppression may minimize. We hypothesized that these patients, a prolonged withdrawal after graft failure preserves nonsensitization status (PRA 0%) better than early withdrawal. Methods retrospectively examined subjects transplanted single center between July 1, 1999 and December 2009...
A liver, heart, iliac vessel and two kidneys were recovered from a 39-year-old man who died of traumatic head injury transplanted into five recipients. The liver recipient 18 days posttransplantation presented with headache, ataxia fever, followed by rapid neurologic decline death. Diagnosis granulomatous amebic encephalitis was made on autopsy. Balamuthia mandrillaris infection confirmed immunohistochemical polymerase chain reaction (PCR) assays. Donor recipients' sera tested for B....
The performance of belatacept in a real clinical setting has not been reported. A retrospective cohort study was conducted using registry data comparing 1-year outcomes between belatacept- and tacrolimus-treated adult kidney transplant recipients (KTRs) from January 6, 2011, through 12, 2014. Of 50 244 total patients, 417 received plus tacrolimus, 458 alone, 49 369 tacrolimus alone at discharge. In the overall cohort, associated with higher risk acute rejection, highest rates...
In carefully selected individuals, receiving expanded criteria donor (ECD) kidneys confer a survival advantage over remaining on dialysis. However, wait lists for ECD often include significant proportion of young patients, who have no predictable benefit from kidneys. This study hypothesized that educational and socioeconomic factors might influence younger patient's decision to accept an kidney.This was retrospective analysis all first single-kidney transplants in the Scientific Registry...
This study aimed to analyze adult kidney transplant recipients (KTRs) for the risk of new-onset diabetes after transplantation (NODAT) associated with viral serologies and immunosuppression regimens [tacrolimus (Tac) + mycophenolate (MPA), cyclosporine (CSA) MPA, sirolimus (SRL) SRL CSA or +Tac].Cox regression models were used examine NODAT in first posttransplant year with: (i) MPA Tac versus reference, MPA; (ii) pretransplant serology [+ -; hepatitis B core (HBc), C (HCV), cytomegalovirus...
IT in the civil engineering curriculum is often fragmented into courses that emphasize either design tools (e.g., CAD), or packages for analysis, planning and modeling. Graduating students report a lack of coherence used their distinctive gap junior years where technology skills are under-used forgotten. Building information modeling (BIM) may offer opportunity to unify disparate technologies provide coherent skill set address range problems infrastructure facilities life cycle. BIM...
Introduction Diabetes mellitus is a leading cause of kidney disease. Accepting living donors with diabetes remains debatable issue. The necessity this article's proposal resulted from recent Organ Procurement and Transplantation Network (OPTN) policy amendments regarding the acceptance (1). For frame reference, European Best Practices Guidelines qualify preexisting only under "exceptional circumstances" (2). British Society offers opinion-based recommendation that "diabetics can be...
Abstract Background The influence of converting to once daily, extended‐release LCP‐Tacrolimus (Tac) for those with high tacrolimus variability in kidney transplant recipients (KTRs) is not well‐studied. Methods Single‐center, retrospective cohort study adult KTRs converted from Tac immediate release LCP‐Tac 1‐2 years post‐transplant. Primary measures were variability, using the coefficient variation (CV) and time therapeutic range (TTR), as well clinical outcomes (rejection, infections,...
Single-cell sequencing (sc-Seq) experiments are producing increasingly large data sets. However, sets do not necessarily contain amounts of information.Here, we formally quantify the information obtained from a sc-Seq experiment and show that it corresponds to an intuitive notion gene expression heterogeneity. We demonstrate natural relation between our heterogeneity cell type, decomposing into component attributable differential types (inter-cluster heterogeneity) remaining (intra-cluster...
We studied registry data of 12,944 adult kidney retransplant recipients categorized by induction regimen received into antithymocyte globulin (ATG) ( N = 9120), alemtuzumab 1687), and basiliximab 2137) cohorts. analyzed risk factors for 1-year acute rejection (AR) 5-year death-censored graft loss (DCGL) patient death. Compared with the reference, basiliximab: (1) one-year AR was lower ATG in expanded criteria deceased-donor kidneys (HR 0.56, 95% CI 0.35–0.91 HR 0.54, 0.27–1.08, resp.), while...
The risks for transplant outcomes associated with baseline viral serostatus in kidney recipients (KTR) on sirolimus have not been widely studied.We performed a cohort-study of 61 590 adult KTR 2000 to 2013. We used Cox regression models determine the adjusted hazard ratio (aHR) patient death, death-censored graft loss and posttransplant malignancy (+ or -: hepatitis B core [HBc], C virus [HCV], Epstein-Barr [EBV], cytomegalovirus [CMV]) (SRL) + mycophenolate (MPA) SRL tacrolimus (Tac),...
The Organ Procurement and Transplantation Network (OPTN) approved changes to the US kidney allocation system in 2019. potential effects of this policy change using transplant rates normalized end-stage disease (ESKD) incidence have not been investigated.
To mitigate the effects of obscuration and attenuation, free space optical (FSO) wireless networks employ topology control to dynamically reconfigure node connectivity based on changes in link state. Our previous research has focused primarily creating heuristics for computing an optimal either physical layer (minimize bit error rate) or network congestion). This presents a multi-objective optimization formulation problem whereby cost congestion are jointly minimized. uses weighting method...
Despite the continued improvements in pancreas transplant outcomes recent decades, a subset of recipients experience graft failure and can substantial morbidity mortality. Here, we summarize what is known about failed allograft factors are important for consideration retransplantation. The current definition its challenges community explored. impacts presented, including patient survival resultant morbidities. signs, symptoms, medical surgical management described, whereas options...