A5013648366- Renal Transplantation Outcomes and Treatments
- Neurological Complications and Syndromes
- Pharmacological Effects and Toxicity Studies
- Transplantation: Methods and Outcomes
- HIV/AIDS drug development and treatment
Medical University of South Carolina
2023
Abstract Background The influence of converting to once daily, extended‐release LCP‐Tacrolimus (Tac) for those with high tacrolimus variability in kidney transplant recipients (KTRs) is not well‐studied. Methods Single‐center, retrospective cohort study adult KTRs converted from Tac immediate release LCP‐Tac 1‐2 years post‐transplant. Primary measures were variability, using the coefficient variation (CV) and time therapeutic range (TTR), as well clinical outcomes (rejection, infections,...
Diabetes (DM) is a common comorbidity in transplant patients with known effects on gastrointestinal (GI) motility and absorption; however, DM's impact immediate release (IR) tacrolimus to LCP-tacrolimus (LCP) conversion ratios has not been studied. This multivariable analysis of retrospective longitudinal cohort study included kidney recipients converted from IR LCP between 2019 2020. The primary outcome was ratio based DM status. Other outcomes variability, rejection, graft loss, death. Of...
Abstract Outcomes analyzing conversion from IR‐tacrolimus (IR) to LCP‐tacrolimus (LCP) in obesity are limited. This was a retrospective longitudinal cohort study of patients converted IR LCP June 2019 October 2020. Primary outcomes were ratios for weight‐based dose at steady‐state therapeutic level and identification appropriate dosing weight. Other included tacrolimus coefficient variation (CV), time range (TITR), adverse events, infections, donor specific antibodies (DSAs), acute...