A5101844946- Neuroblastoma Research and Treatments
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Immune Response and Inflammation
- Nicotinic Acetylcholine Receptors Study
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Immunodeficiency and Autoimmune Disorders
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Hemoglobinopathies and Related Disorders
- interferon and immune responses
- Extracellular vesicles in disease
- Virus-based gene therapy research
- Receptor Mechanisms and Signaling
- Cancer-related Molecular Pathways
- Ocular Oncology and Treatments
- Vagus Nerve Stimulation Research
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Immune responses and vaccinations
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
Sheba Medical Center
2024
University of California, San Diego
2014-2021
UC San Diego Health System
2018
Tel Aviv University
2011-2014
Rabin Medical Center
2011
Abstract Neuroblastoma is a pediatric cancer with significant genomic and biologic heterogeneity. p16 ARF, two important tumor-suppressor genes on chromosome 9p21, are inactivated commonly in most cancers, but paradoxically overexpressed neuroblastoma. Here, we report that exon γ also part of an undescribed long noncoding RNA (lncRNA) have termed CAI2 (CDKN2A/ARF Intron 2 lncRNA). single-exon gene poly A signal located independent the p16/ARF 3. expressed at very low levels normal tissue,...
Leukocyte ECRG4 amplifies neutrophil recruitment and regulates CD44 expression to mediate inflammation in cutaneous injury.
Significance The emergence of uniquely human genes during hominid speciation enabled numerous human-specific adaptations that presumably included changes in resilience to disease but potentially increased susceptibility as well. Here we show the transgenic expression one such gene, called CHRFAM7A, mouse reservoir hematopoietic stem cells bone marrow and amplifies inflammatory response a model systemic syndrome (SIRS). Because CHRFAM7A gene is dominant-negative inhibitor ligand binding α7...
Mantle cell lymphoma (MCL) is a hematological malignancy with unfavorable prognosis. Novel therapeutic approaches for treating the disease are aimed at mechanisms regulating growth signals, cellular proliferation, and survival pathways of malignant clones. Bortezomib (Brt), proteasome inhibitor pleiotropic activities was shown to be active in MCL currently implemented combinations this disease. Telomerase activity essential cells as such considered valid target. This study evaluated effects...
<h3>Background</h3> Immunotherapy includes approaches such as immune checkpoint blockade (ICB), adoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocytes (TILs), and genetic engineering T-cell receptor (TCR) engineering. Uveal melanoma (UM) is a rare from melanocytes in the uvea. Despite success of ICB treating cutaneous melanoma, UM far less responsive to current immunotherapies. The primary events driving malignancy over 95% cases are recurrent mutations highly homologous...
Abstract We have recently reported on the discovery of a long non-coding RNA imbedded in intron 2 p16/ARF (CDKN2A) locus at 9p21. CAI2 is non-conserved, pol II regulated gene with whose expression highly correlated parent genes p16 and ARF. However, expressed cell lines deleted for p16, ARF even p15, epigenetically silenced and/or Furthermore, treatment 5-aza-2’-deoxycytidin allows re-expression while having no influence CAI2, confirming independent regulation. Speculating, therefore, that...
Abstract Over the last several years it has become apparent that majority of genome is transcribed with number non-coding RNA (ncRNA) genes significantly higher than protein-encoding genes. The 9p21 locus harbors a tumor suppressor including p15, p10, ARF, chARF, p16, p16γ, p12 and p16-ACT, long ncRNAs ANRIL p15AS. abundance regulatory in such short span perhaps accounts for why this region frequently inactivated many cancers. We report on novel lncRNA CAI2, non-conserved gene imbedded...
<p>CAI2, p16 and ARF expression in normal tissue compared to levels fibroblasts (Supp Figure S1); Growth comparison of low vs. high passage NMB7 cells S2); the absence serum or presence RA S3).</p>
<p>CAI2 sequence and features (Supp Table S1); CAI2, ARF p16 expression in various tumor cell lines normal cells S2); Morphological assessment of low high passage NMB7 after treatment by serum starvation or RA S3).</p>
<p>Legend for Supplemental Figures S1-S3.</p>
<p>CAI2, p16 and ARF expression in normal tissue compared to levels fibroblasts (Supp Figure S1); Growth comparison of low vs. high passage NMB7 cells S2); the absence serum or presence RA S3).</p>
<p>CAI2 sequence and features (Supp Table S1); CAI2, ARF p16 expression in various tumor cell lines normal cells S2); Morphological assessment of low high passage NMB7 after treatment by serum starvation or RA S3).</p>
<p>Legend for Supplemental Figures S1-S3.</p>
<div>Abstract<p>Neuroblastoma is a pediatric cancer with significant genomic and biologic heterogeneity. <i>p16</i> <i>ARF</i>, two important tumor-suppressor genes on chromosome <i>9p21</i>, are inactivated commonly in most cancers, but paradoxically overexpressed neuroblastoma. Here, we report that exon γ also part of an undescribed long noncoding RNA (lncRNA) have termed <i>CAI2</i> (<i>CDKN2A/ARF</i> Intron 2...
<div>Abstract<p>Neuroblastoma is a pediatric cancer with significant genomic and biologic heterogeneity. <i>p16</i> <i>ARF</i>, two important tumor-suppressor genes on chromosome <i>9p21</i>, are inactivated commonly in most cancers, but paradoxically overexpressed neuroblastoma. Here, we report that exon γ also part of an undescribed long noncoding RNA (lncRNA) have termed <i>CAI2</i> (<i>CDKN2A/ARF</i> Intron 2...
Abstract Background: The proteasome inhibitor bortezomib (B) is an effective drug in multiple myeloma (MM). However, its exact mode of action not yet fully understood. importance telomerase activity (TA) the biology and prognosis MM well established, but response to B has been assessed yet. In light common signaling pathways connecting regulation known mechanisms action, we surmised that may affect cells. Methods: Two cell lines, ARP-1 CAG, were exposed for 24-72 hours. Viability was by...
Conclusion(s):It is essential to consider BSS within the differential diagnosis of adult patients presenting with thrombocytopenia and giant platelets in blood smear.BSS a rare disorder that may easily have been underdiagnosed or misdiagnosed earlier life.The presence chronic macrothrombocytopenia two siblings raised suspicion for an underlying genetic condition.
Abstract Introduction CHRFAM7A is a uniquely human gene that dominant negative inhibitor of the alpha-7 nicotinic acetylcholine receptor (a7nAchR). The relative balance and a7nAchR expression may play an important role in mediating immune response to injury. We have previously shown increased hematopoietic stem cell reservoir bone marrow altered emergency myelopoiesis after Here, we hypothesized loss would produce phenotype similar overexpression, with cells modulate myeloid mobilization...