A5041468886- RNA Research and Splicing
- Developmental Biology and Gene Regulation
- Neurobiology and Insect Physiology Research
- Estrogen and related hormone effects
- Plant Molecular Biology Research
- Genetics, Aging, and Longevity in Model Organisms
- Heat shock proteins research
- Immune Response and Inflammation
- 14-3-3 protein interactions
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Signaling Pathways in Disease
- Hippo pathway signaling and YAP/TAZ
- Chromosomal and Genetic Variations
- Neuropeptides and Animal Physiology
- Invertebrate Immune Response Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
Institut de Biologia Molecular de Barcelona
2015-2018
Consejo Superior de Investigaciones Científicas
2016-2018
Epithelial renewal in the Drosophila intestine is orchestrated by Intestinal Stem Cells (ISCs). Following damage or stress intestinal epithelium produces ligands that activate epidermal growth factor receptor (EGFR) ISCs. This promotes their and division and, thereby, epithelial regeneration. Here we demonstrate HMG-box transcriptional repressor, Capicua (Cic), mediates these functions of EGFR signaling. Depleting Cic ISCs activated them for division, whereas overexpressed inhibited ISC...
HMG-box proteins, including Sox/SRY (Sox) and TCF/LEF1 (TCF) family members, bind DNA via their HMG-box. This binding, however, is relatively weak both Sox TCF factors employ distinct mechanisms for enhancing affinity specificity DNA. Here we report that Capicua (CIC), an transcriptional repressor involved in Ras/MAPK signaling cancer progression, employs additional mode of binding enables selective recognition its targets. We find that, contrary to previous assumptions, the CIC does not...
The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor that functions downstream of receptor tyrosine kinase (RTK) signaling pathways in relatively simple switch: In the absence signaling, Cic represses RTK-responsive genes by binding to nearly invariant sites DNA, whereas activation RTK down-regulates activity, leading derepression its targets. This mechanism controls gene expression both Drosophila and mammals, but whether can also function via other regulatory...
Significance The transcriptional repressor protein Capicua (Cic) is a conserved regulator of organ growth and tissue patterning, mutations in the CIC gene humans result brain cancer oligodendroglioma. Cic activity controlled by receptor tyrosine kinase (RTK) signaling pathway. Here, we identify Minibrain (Mnb) its adaptor Wings apart (Wap) as regulators. Mnb Wap bind to phosphorylate protein, inhibit ability repress expression. Mnb-dependent down-regulation necessary for proper multiple...
Receptor Tyrosine Kinase (RTK) signaling pathways induce multiple biological responses, often by regulating the expression of downstream genes. The HMG-box protein Capicua (Cic) is a transcriptional repressor that downregulated in response to RTK signaling, thereby enabling RTK-dependent induction Cic targets. In both Drosophila and mammals, expressed as two isoforms, long (Cic-L) short (Cic-S), whose functional significance mechanism action are not well understood. Here we show relies on...