A5029206086- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Infective Endocarditis Diagnosis and Management
- Bacterial Identification and Susceptibility Testing
- Diet, Metabolism, and Disease
- Parvovirus B19 Infection Studies
- Autoimmune and Inflammatory Disorders Research
- Diet and metabolism studies
- Pharmacy and Medical Practices
- Pancreatic function and diabetes
- Inflammasome and immune disorders
- Pharmaceutical Practices and Patient Outcomes
Advocate Health Care
2024-2025
Advocate Lutheran General Hospital
2022-2025
University of Illinois Chicago
2017-2019
Safe anaerobic metabolism Naked mole-rats live in large colonies deep underground hypoxic conditions. Park et al. found that these animals fuel glycolysis with fructose by a rewired pathway avoids tissue damage (see the Perspective Storz and McClelland). These results provide insight into adaptations this strange social rodent has to make for life underground. They also have implications medical practice, particularly understanding how protect tissues from hypoxia. Science , issue p. 307 ; see 248
Abstract Background Rapid diagnostic technology is an important tool that can be used to optimize antimicrobial therapy for patients with bloodstream infections Several technologies rapid organism identification exist including matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) and multiplex polymerase chain reaction (PCR). The primary objective compare time optimal MALDI-TOF MS vs PCR systems positive blood cultures. Methods This multicenter,...
Abstract Background Inappropriate antibiotic exposure places patients at risk for collateral damage. Hospital discharge presents an opportunity to ensure regimens represent appropriate continuation of inpatient therapy and adhere evidence-based activity spectrum duration recommendations. We sought determine the impact a pharmacist-led stewardship intervention on oral prescribing hospital discharge, informed by institutional guidelines targeted pharmacist education. Methods This was...
Abstract Objective: To identify institution-specific risk factors for extended-spectrum beta-lactamase (ESBL) bloodstream infections (BSI) to develop and validate a assessment scoring tool that can be utilized hospitalized patients. Design: Single-center, retrospective, case-control study. Setting: Tertiary teaching hospital. Patients: Hospitalized adult pediatric patients with E. coli or Klebsiella spp. BSI were stratified based on ESBL production between August 2019 July 2021. Exclusion...
Abstract Background Infections caused by extended-spectrum ß-lactamase (ESBL) producing organisms pose a unique challenge for infection control. The preferred agents treatment of infections due to ESBL-producing bacteria are carbapenems. Data from prior studies suggest that hypoalbuminemia may have profound effect on the pharmacodynamic properties ertapenem. Our hypothesis is ertapenem usage in patients with will lead negative clinical outcomes such as recurrence, hospital readmission, and...
Abstract Human granulocytic anaplasmosis and Lyme disease are tick-borne infections transmitted by the same vector, Ixodes scapularis , commonly isolated in areas within Midwest region of United States. Although typically associated with mild symptoms, both can progress to severe disease. Treatment choice for a majority illness is doxycycline; however, options limited setting tetracycline allergy. Here, we present complex case human anaplasmosis–induced hemophagocytic lymphohistiocytosis...
Abstract Background Recent literature suggests that AmpC production may be overcalled in Enterobacterales, leading to unnecessary broad-spectrum antimicrobial utilization. The Infectious Diseases Society of America (IDSA) has since reassessed classification high and low risk organisms with inducible expression. With this updated guidance, our health system approved changes microbiology reporting producers an effort guide prescribing appropriate antibiotics. primary objective project was...
Abstract Background Pseudomonas aeruginosa (PsAr) isolates harboring OprD mutations often present phenotypically as carbapenem nonsusceptible but susceptible to antipseudomonal β-lactams (APBLs). It is unknown whether this unique genotype–phenotype combination affects the clinical outcomes of patients infected with these pathogens. The objective study was compare treated APBLs for pneumonia and/or bacteremia caused by PsAr bearing nonsusceptible, β-lactam phenotype (Carba-NS) those retaining...