A5054563185- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Circular RNAs in diseases
- Semiconductor materials and devices
- Colorectal and Anal Carcinomas
- RNA Research and Splicing
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Advancements in Semiconductor Devices and Circuit Design
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Microtubule and mitosis dynamics
- Cancer Cells and Metastasis
- Silicon Carbide Semiconductor Technologies
- RNA modifications and cancer
- Immune cells in cancer
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
Guangdong Pharmaceutical University
2023-2024
Bioscience (China)
2024
University of Kentucky
2014-2023
Markey Cancer Center
2023
Tumor immune evasion relies on the crosstalk between tumor cells and adaptive/innate cells. Immune checkpoints play critical roles in crosstalk, checkpoint inhibitors have achieved promising clinical effects. The long non-coding RNA taurine-upregulated gene 1 (TUG1) is upregulated hepatocellular carcinoma (HCC). However, how TUG1 effects are incompletely understood. Here, METTL3-mediated m
Abstract This study presents an effective approach for stabilizing the threshold voltage (Vth) through development of innovative split-decoupled gate p-GaN HEMT (SDG-HEMT) architecture, which utilizes spatially differentiated contacts. The proposed design features embedded dual-contact configuration comprising a Schottky contact and Ohmic contact. Under high drain operation, architecture achieves three synergistic stabilization mechanisms: (i) capacitive decoupling gate-drain coupling...
Cancer-associated fibroblasts (CAFs) are heterogeneous constituents of the tumor microenvironment involved in tumorigenesis, progression, and therapeutic responses tumors. This study identified four distinct CAF subtypes breast cancer (BRCA) using single-cell RNA sequencing (RNA-seq) data. Of these, matrix CAFs (mCAFs) were significantly associated with remodeling strongly correlated transforming growth factor (TGF)-β signaling pathway. Consensus clustering The Cancer Genome Atlas (TCGA)...
Abstract Background Chronic inflammation is considered the most critical predisposing factor of hepatocellular carcinoma (HCC), with inflammatory cell heterogeneity, hepatic fibrosis accumulation, and abnormal vascular proliferation as prominent features HCC tumor microenvironment (TME). Cancer‐associated fibroblasts (CAFs) play a key role in TME remodeling. Therefore, level abundance CAFs may significantly affect prognosis outcome patients. Methods Unsupervised clustering was performed...
Tumor dormancy is a stage in the growth and development of malignant cells one biological characteristics cells. Complex transitions involving dormant tumor between quiescent proliferative states pose challenges for eradication. This paper explores features molecular mechanisms highlights emerging therapies. The strategies discussed promise innovative clinical potential against tumors. Understanding can help provide valuable insights into diagnosis treatment tumors to advance fight this...
Abstract This paper presents a comprehensive analysis of the short-circuit failure mechanisms in commercial 1.2 kV planar silicon carbide (SiC) metal–oxide–semiconductor field-effect transistors (MOSFETs) under 400 and 800 V bus voltage conditions. The study compares two products with varying tolerances, scrutinizing their external characteristics intrinsic factors that influence endurance. Experimental numerical analyses reveal at V, differential thermal expansion between source metal...
BACKGROUND: Radiation therapy (RT) is the standard of care for GBM. Analysis Surveillance, Epidemiology, and End Results (SEER) database by several investigators including our group have demonstrated 27% GBM cases did not receive upfront radiation had a poorer survival outcome. Our study sought to investigate sociodemographic factors in this group. METHODS: We analyzed SEER 18 dataset patients that are 20 years older from 2000-2010 (n = 23,595). All statistical tests were two-sided,...
Withdrawal statement The authors have withdrawn their manuscript owing to the identification of inadequate informed consent procedures in this research. Therefore, do not wish work be cited as reference for project. If you any questions, please contact corresponding author.