A5100751244- Virus-based gene therapy research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Aquaculture disease management and microbiota
- Viral Infectious Diseases and Gene Expression in Insects
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Sports Performance and Training
- Monoclonal and Polyclonal Antibodies Research
- Animal Virus Infections Studies
- Immune cells in cancer
- Sports injuries and prevention
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Invertebrate Immune Response Mechanisms
- Ferroptosis and cancer prognosis
- Genetics, Aging, and Longevity in Model Organisms
- Advanced biosensing and bioanalysis techniques
- RNA regulation and disease
- RNA Interference and Gene Delivery
- Photosynthetic Processes and Mechanisms
- Advanced Nanomaterials in Catalysis
- T-cell and B-cell Immunology
- Oral and Maxillofacial Pathology
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022-2025
Sun Yat-sen University
2019-2025
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2024-2025
Macau University of Science and Technology
2022-2025
Key Laboratory of Guangdong Province
2014-2024
Guangdong Pharmaceutical University
2014-2024
Guangzhou Sport University
2022-2024
Xichang University
2024
Sichuan Agricultural University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
An overview on the recent progress in bimetallic MOFs regarding their design strategies, syntheses and multifarious applications.
N6-methyladenosine (m6A), the most abundant mRNA modification in mammals, is involved various biological processes. KIAA1429 an important methyltransferase participating m6A modification. However, role of hepatocellular carcinoma (HCC) still not well understood. Here, we aimed to investigate function and its corresponding regulation mechanisms HCC.HCC-related genes were analyzed by clinical expression data HCC patients The Cancer Genome Atlas (TCGA) database. Expression was verified...
Tricaine is a common anesthetic used in the long-distance transport of live fish. Recently, its negative impact on human health has aroused extensive concern. Thus, rapid and reliable techniques for tricaine residue analysis are essential to ensuring quality aquatic products. Herein, specific anti-tricaine monoclonal antibody (Mab) was prepared. Then, sensitive robust ratiometric fluorescence ELISA (RF-ELISA) constructed detecting based two MnO2 nanoflake-mediated (MnO2 NFs) fluorogenic...
The genus Megalocytivirus of the family Iridoviridae is composed two distinct species, namely, infectious spleen and kidney necrosis virus (ISKNV) scale drop disease (SDDV), both are important causative agents in a variety bony fish worldwide. Of them, ISKNV species subdivided into three genotypes, red seabream iridovirus (RSIV), ISKNV, turbot reddish body (TRBIV), further six subgenotypes, RSIV-I, RSIV-II, ISKNV-I, ISKNV-II, TRBIV-I, TRBIV-II. Commercial vaccines derived from RSIV-I ,...
High temperature is a critical abiotic stress that reduces crop yield and quality. Rice (Oryza sativa L.) plants remodel their proteomes in response to high stress. Moreover, phosphorylation the most common form of protein post-translational modification (PTM). However, differential expression phosphoproteins induced by heat rice remains unexplored.Phosphoprotein leaves under were displayed using two-dimensional electrophoresis (2-DE) Pro-Q Diamond dye. Differentially expressed identified...
// Geng Tian 1, * , Fangrong Tang 2, Chunhua Yang 1 Wenfeng Zhang 2 Jonas Bergquist 3 Bin Wang Jia Mi and Jiandi Medicine Pharmacy Research Center, Binzhou Medical University, Yantai, P. R. China Yantai Zestern Biotechnique Co. LTD, Department of Chemistry, BMC, Uppsala Uppsala, Sweden These authors have contributed equally to this work Correspondence to: Zhang, email: Jiandi.zhang@zestern.net Mi, jiajiami@gmail.com Keywords: quantitative dot blot, high throughput, proteomics, immunoblot...
Rationale: Keytruda (pembrolizumab) is an inhibitor of programmed cell death receptor-1 (PD-1), which was approved to treat advanced melanoma and nonsmall lung cancer patients who do not respond other treatment. However, its efficacy security in the treatment liver still under investigation. Patient concerns: A 60-year-old man diagnosed with pulmonary metastatic accepted pembrolizumab after failure sorafenib. When injected pembrolizumab, spite lesion shrink, patient experienced severe...
Background: Astragalus polysaccharides (APS), natural plant compounds, have recently emerged as a promising strategy for cancer treatment, but little is known concerning their effects on breast (BC) tumourigenesis. Methods: We obtained genetic data from The Cancer Genome Atlas (TCGA) database, network pharmacology to further clarify its biological properties. Survival analysis and molecular docking techniques were implemented the final screening obtain key target information. Our experiments...
CCL17 is an important chemokine that plays a vital immunomodulatory role in the tumor microenvironment (TME). Analysis of lung adenocarcinoma (LUAD) data Kaplan-Meier plotter databases found overall survival patients high-expression group was higher than low-expression group, especially for with early (stages I and II) LUAD, which has more positive prognostic value. Expression LUAD positively correlated proportion tumor-infiltrating lymphocytes, immunostimulators, major histocompatibility...
Compared with primary tumor sites, metastatic sites appear more resistant to treatments and respond differently the treatment regimen. It may be due heterogeneity in microenvironment between tumors. Cancer‑associated fibroblasts (CAFs) are widely present stroma as key components of microenvironment. Primary CAFs (pCAFs) (mCAFs) heterogeneous terms source, activation mode, markers functional phenotypes. They can shape according organ, showing tumors metastases, which affect sensitivity these...