A5101643872- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Aquaculture disease management and microbiota
- Plant Pathogens and Fungal Diseases
- Advanced Sensor and Energy Harvesting Materials
- RNA and protein synthesis mechanisms
- Alkaloids: synthesis and pharmacology
- Antifungal resistance and susceptibility
- Extraction and Separation Processes
- Minerals Flotation and Separation Techniques
- Micro and Nano Robotics
- Pharmaceutical and Antibiotic Environmental Impacts
- Ergonomics and Musculoskeletal Disorders
- Korean Urban and Social Studies
- Sesquiterpenes and Asteraceae Studies
- Metal Extraction and Bioleaching
- Microbial Metabolism and Applications
- Advanced Materials and Mechanics
- Peroxisome Proliferator-Activated Receptors
- Parasitic Infections and Diagnostics
- Phytochemistry and Bioactive Compounds
- Diet and metabolism studies
- Schizophrenia research and treatment
- Phytochemistry and Biological Activities
- Personality Disorders and Psychopathology
Seoul National University
2019-2024
Chonnam National University Hospital
2020
Sogang University
2009
An entirely stretchable origami inspired by pelican eels is unfolded and stretched to create adaptive, extreme shape morphing.
Feature-based molecular networking analysis suggested the presence of naphthol tetramers in Daldinia childae 047219, same species but a different strain from one used previously for discovery trimers promoting adiponectin synthesis. The new were composed 5-methoxy-4-naphthol, each which was connected to another various positions. Targeted isolation afforded six unreported (1–6) together with 13 known polyketides (7–19) including monomers, dimers, and trimers. Structures isolated compounds...
Adiponectin-synthesis-promoting compounds possess therapeutic potential to treat diverse metabolic diseases, including obesity and diabetes. Phenotypic screening find adiponectin-synthesis-promoting was performed using the adipogenesis model of human bone marrow mesenchymal stem cells. The extract endolichenic fungus Daldinia childiae 047215 significantly promoted adiponectin production. Bioactivity-guided isolation led 13 active polyketides (1-13), which include naphthol monomers, dimers,...
The endophytic fungus Colletotrichum gloeosprioides JS0419, isolated from the leaves of halophyte Suaeda japonica, produced four new β-resorcylic acid derivatives, colletogloeopyrones A and B (1 2) colletogloeolactones (3 4), seven known lactones (RALs). structures these compounds were elucidated via analysis high-resolution mass spectrometry nuclear magnetic resonance data. Compounds 1 2 showed a dihydrobenzopyranone ring with linear C9 side chain, which is rarely observed in RALs. All...
Abstract Background Salinomycin, an antibiotic, have potential as a veterinary drug for fish due to its anti-parasitic activity against several parasites. Thus the residual levels of salinomycin in muscles two significant aquaculture species Korea, olive flounder and black rockfish, were analyzed using HPLC-MS-MS. Results The proper method analyze LC-MS-MS was settled validated according CODEX guidelines. residues three distinct groups matrix match calibration curves at points five different...
Six new β-resorcylic acid derivatives (1–5 and 7) were isolated from a halophyte-associated fungus, Colletotrichum gloeosporioides JS0419, together with four previously reported lactones (RALs). The relative absolute stereochemistry of 1 was completely established by combination spectroscopic data chemical reactions. structures the compounds elucidated analysis HRMS NMR data. Notably, 1–3 had harboring long unesterified aliphatic side chain, whereas chains esterified to form macrolactones in...
Fourteen azaphilone-type polyketides (1–14), including nine new ones (1–6 and 8–10), were isolated from cultures of Vitex rotundifolia-associated Penicillium sp. JVF17, their structures determined by spectroscopic analysis together with computational methods chemical reactions. Neuroprotective effects the compounds evaluated against glutamate-induced neurotoxicity. Treatment 3, 6, 7, 11–14 increased cell viabilities hippocampal neuronal cells damaged glutamate, compound 12 being most potent....
Three new cyclic peptide–polyketide hybrids (1–3) and two chaetiacandin-type polyketides (4 5) along with nine known compounds were isolated from cultures of a halophyte-associated fungus, Colletotrichum gloeosporioides JS0417. Spectroscopic analysis revealed that 1–3 depsipeptides where 3,5,11-trihydroxy-2,6-dimethyldodecanoic acid was linked to amino acids through amide ester bonds form 12-membered ring. Relative absolute configurations for the peptides determined spectroscopic chemical...
In an effort to activate silent biosynthetic gene clusters, Streptomyces samsunensis DSM42010, a producer of geldanamycin, was cultured at four different pHs (4.5, 5.4, 6.6, and 7.4). An acidic culture condition (pH 5.4) selected for chemical investigation since S. showed metabolic profile compared when it under other conditions. Seven new (1-7) known (8-11) compounds were isolated from these cultures. The structures the determined by spectroscopic techniques derivatization. Relative...
Objectives This study aimed to identify factors affecting the duration of untreated psychosis (DUP) in patients with schizophrenia spectrum disorder. Methods Six-hundred disorder were recruited from mental health welfare centers Gwangju Metropolitan City and Gyeonggi-do. Subjects categorized into two groups according median DUP. Demographic clinical characteristics compared between groups. Results The mean DUP was 80.8 weeks, 15.9 weeks. Patients Medicaid, higher age, longer prodrome more...
Recently, a 3D cross-point array (3DXP) consisting of phase-change random-access-memory (PCRAM) and ovonic threshold switching (OTS) selector has been reported as memory solution for next-generation Compute-Express-Link (CXL) interconnect technology due to nonvolatile characteristics high scalability 1 . Neverthless, 3DXP faced limitations in implementing vertically-stacked high-density the aspect ratio serial connection two devices (i.e., PCRAM OTS selector) thermal disturbance (TDB)...
Aquaculture, a crucial sector of the global food industry, faces myriad issues due to parasitic invasions. One such parasite, Microcotyle sebastis, which afflicts Korean rockfish in South Korea, has significant economic impact. The impending danger resistance traditional anthelmintics necessitates exploration new antiparasitic candidates. Although efficacy salinomycin against aquatic parasites as ciliates and sporozoans is known, its influence on monogeneans yet be studied. Therefore, this...
Vitamin D levels are low in patients with schizophrenia. This study examined the association between vitamin and metabolic syndrome psychotic disorders. The enrolled 302 community-dwelling Sociodemographic clinical characteristics, including blood pressure, physical activity, dietary habit were gathered. Laboratory examinations included D, lipid profile, fasting plasma glucose, HbA1c, liver function, renal function. insufficiency was defined as < 20 ng/ml. Clinical characteristics associated...
Objective: The aims of this study is to compare the workloads at different work-rest period (Standard & non-standard work) in lumbar flexion work and find a more suitable cycle time for worker.BRBRBackground: In industrial field, there are many works that cause it main risk factor associated with Work-related Musculoskeletal Disorders (WMSDs). To reduce workload worker, lot has been studied on standard working hours. Nevertheless,