A5103277866- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Muscle metabolism and nutrition
- RNA Research and Splicing
- Cardiomyopathy and Myosin Studies
Nantes Université
2018-2023
Duchenne Muscular Dystrophy (DMD) is a severe muscle-wasting disease caused by mutations in the DMD gene encoding dystrophin, expressed mainly muscles but also other tissues like retina and brain. Non-progressing cognitive dysfunction occurs 20 to 50% of patients. Furthermore, loss expression Dp427 dystrophin isoform brain mdx mice, most used animal model DMD, leads behavioral deficits thought be linked insufficiencies synaptogenesis channel clustering at synapses. Mdx mice where locomotor...
Inflammation and oxidative stress are strongly implicated in the pathology of Duchenne muscular dystrophy (DMD), sulphur-containing amino acid taurine ameliorates both decreases dystropathology mdx mouse model for DMD. We therefore further tested as a therapy using dystrophic DMDmdx rats dmd zebrafish models DMD that have more severe dystropathology. However, treatment had little effect on indices these models. While we others previously observed deficiency mice, current study show rat...