A5032101050- Heart Rate Variability and Autonomic Control
- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiovascular and exercise physiology
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Embedded Systems Design Techniques
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- Sports Performance and Training
- Interconnection Networks and Systems
- Venous Thromboembolism Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Climate Change and Health Impacts
- Parallel Computing and Optimization Techniques
- Cardiovascular Effects of Exercise
- COVID-19 and healthcare impacts
Oita University
2016-2025
Toyo University
2019-2025
Tokyo Polytechnic University
2025
Oita Red Cross Hospital
2025
Oita University Hospital
2024
Nara Medical University
2022
Bioengineering Center
2014
Itron (United States)
2014
National Cancer Registry
2014
American Heart Association
2014
We investigated whether glucose fluctuations aggravate cardiac fibrosis and increase the occurrence of atrial fibrillation (AF) in rats with diabetes mellitus (DM). Streptozotocin-induced diabetic were randomly divided into three groups: uncontrolled DM (U-STZ) group, controlled (C-STZ) (STZ-GF) group. Glucose induced by fasting for 24 h additional regular insulin injections (0.5 IU/kg) administered times per week consecutive weeks. C-STZ long acting (20 twice a day to control blood levels....
Obesity, characterized by systemic low-grade inflammation, is considered a well-known risk for atrial fibrillation. In fact, IL-10 (interleukin 10), which potent anti-inflammatory cytokine, has been reported to decrease in obese and diabetic patients. We tested the hypotheses forwarding that genetic deletion of exacerbates high-fat diet (HFD)-induced obesity-caused lipidosis, fibrosis, fibrillation therapy inhibits this pathology.Eight- 10-week-old male CL57/B6 (wild-type) mice knockout were...
The prevalence of transthyretin amyloid cardiomyopathy (ATTR-CM) in atrial fibrillation (AF) patients remains unclear. We explored the efficacy computed tomography-based myocardial extracellular volume (CT-ECV) combined with red flags for early screening concealed ATTR-CM AF undergoing catheter ablation.
Renal dysfunction is a major risk factor for atrial fibrillation (AF). The uremic toxin indoxyl sulfate may contribute to the progression of cardiac fibrosis and AF substrate in renal dysfunction.Male Sprague-Dawley rats were assigned randomly following groups: 5/6 nephrectomy (5/6Nx) with vehicle, 5/6Nx AST-120, sham procedure AST-120. Vehicle AST-120 administered 4 weeks. Serum levels IS significantly increased groups. Expression malondialdehyde, an indicator oxidative stress, was...
Atrial fibrillation (AF) is associated with heart failure (HF) rehospitalization in patients preserved ejection fraction (HFpEF).We tested the hypothesis that catheter ablation of AF could reduce HF compared conventional pharmacotherapy HFpEF.Eighty-five consecutive HFpEF (EF ≥ 50% and a history hospitalization) diagnosed as by 12-lead electrocardiogram were retrospectively analyzed. Thirty-five who received (ABL group) 50 treated antiarrhythmic drugs and/or beta-blockers (CNT group). The...
Obesity including metabolic syndrome is an independent risk factor of atrial fibrillation (AF). Although hyperleptinemia usually a characteristic obese subjects, the relationship with fibrosis and AF unknown. We tested hypothesis that high-fat diet (HFD)-induced exacerbates AF.Eight-week-old male C57BL/6 (WT) leptin-deficient ob/ob (Ob) mice were treated normal-fat (NFD) or 60% HFD. After 8 weeks, transesophageal burst pacing electrophysiological study using isolated perfused hearts...
Wrist movements play a crucial role in upper-limb motor tasks. As prosthetic and robotic hand technologies have evolved, increasing attention has been focused on replicating the anatomy functionality of wrist. Closely imitating biomechanics movement mechanisms human limbs is expected to enhance overall performance bionic hands. This study presents design tendon-driven spherical robot wrist, utilizing two pairs cables that mimic antagonist muscle pairs. The are actuated by pulleys driven...
Background: The prognosis of patients with acute myocardial infarction (AMI) in the initial stage coronavirus disease 2019 (COVID-19) outbreak has been reported globally. However, reports on AMI after pandemic are limited worldwide. Methods: This retrospective observational study utilized data from electronic medical records system Oita University Hospital. encompassed who were hospitalized at our hospital for treatment between April 2018 and June 2022. period was categorized into following...
Abstract The present study aims to examine the effect of 4 h continuous sitting on cerebral endothelial function, which is a crucial component blood flow regulation. We hypothesized that may impair function similarly how it affects lower limb vasculature. Thirteen young, healthy participants were instructed remain seated for without moving their limbs. and shear rate (SR) in popliteal internal carotid artery (ICA) measured using duplex Doppler ultrasound. During 4‐h sitting, peripheral...
We have previously reported the advantages of a prehospital 12-lead electrocardiography system (P-ECG) for ST-segment elevation myocardial infarction (STEMI) patients (Circ Rep 2019; Circ J 2022, 2023). Since 2020 with Coronavirus disease 2019 (COVID-19), patient transport situation has changed dramatically. investigated how was by COVID-19. The effect (ECG) also evaluated. Recent urban STEMI who received primary percutaneous coronary intervention (PCI) using P-ECG were assigned to group...
The influence of glucose fluctuations (GF) on cardiovascular complications diabetes mellitus (DM) has been attracting much attention. In the present study, whether GF increase susceptibility to ischemia/reperfusion in heart was investigated.Male rats were randomly assigned either a control, DM, and DM with group. induced by an injection streptozotocin, fluctuation starvation insulin injection. One sequential program comprised 2 hypoglycemic episodes during 4 days. isolated hearts subjected...
Cardiac Sarcoidosis and CRT Outcome Introduction resynchronization therapy (CRT) has been shown to be effective for patients with chronic heart failure; however, the efficacy of in cardiac sarcoidosis (CS) not established. Methods We compared outcomes CS who received dilated cardiomyopathy (DCM). The incidence major adverse cerebral cardiovascular events (MACCE) 11 consecutive (8 females; mean age, 66 ± 8.0 years) were 29 DCM (9 70 8.9 years). Results Females previous right ventricular...
Recently, it was reported that mast cells (MCs) could underlie the mechanisms of several cardiovascular diseases. However, role MCs in diabetes-induced atrial fibrillation (AF) has not been notably investigated. We tested hypothesis MC deficiency attenuates hyperglycemia-induced AF mice.Mast cell-deficient W/W(v) mice, and congenic +/+ littermates (WT) were divided into either vehicle (VEH)-injection group or streptozotocin (STZ)-injection (MCKO-VEH, MCKO-STZ, WT-VEH, WT-STZ groups). On day...
Background During the early phase of coronavirus disease 2019 (COVID-19) pandemic, a global reduction in hospitalizations for acute myocardial infarction (AMI) was observed. Generally, patients experienced increased severity AMI with delays time from symptom onset to treatment during pandemic. However, impact COVID-19 pandemic on in-hospital mortality among remains unclear. This study aimed compare long-term prognosis that observed pre-pandemic period and evaluate influence AMI. Methods We...
MuCCRA-Cube is a scalable three dimensional dynamically reconfigurable processor. By stacking multiple dies connected with inductive-coupling links, the number of PE array can be increased so that required performance achieved. A prototype chip 90nm CMOS process consisting four each which has 4 × was implemented. The vertical link achieved 7.2Gb/s/chip, and average execution time reduced to 31% compared using single chip.
BACKGROUND AND PURPOSE Resveratrol is a polyphenol abundantly found in grape skin and red wine. In the present study, we investigated whether resveratrol exerts protective effects against cardiac ischaemia/reperfusion also explored its mechanisms. EXPERIMENTAL APPROACH Infarct size functional recovery rat isolated perfused hearts subjected to no‐flow global ischaemia followed by reperfusion were measured. Cultured neonatal cardiomyocytes exposed H 2 O (100 µmol·L −1 ) induce cell injury....
Diabetes, characterized by hyperglycaemia, causes sinus node dysfunction (SND) in several rodent models. Interleukin (IL)-10, which is a potent anti-inflammatory cytokine, has been reported to decrease obese and diabetic patients. We tested the hypothesis that administration of IL-10 inhibits development SND caused hyperglycaemia streptozotocin (STZ)-induced mice. Six-week old CL57/B6 (WT) mice were divided into following groups: control, STZ injection, injection with systemic IL-10....