A5025068626- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Bone Tumor Diagnosis and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Facial Trauma and Fracture Management
- Cancer Diagnosis and Treatment
- Dental Radiography and Imaging
- Orthodontics and Dentofacial Orthopedics
- Ear and Head Tumors
- Temporomandibular Joint Disorders
- Cardiovascular Disease and Adiposity
- Craniofacial Disorders and Treatments
- Head and Neck Surgical Oncology
- Enzyme Structure and Function
- Advanced Condensed Matter Physics
- Physics of Superconductivity and Magnetism
- Amino Acid Enzymes and Metabolism
- Periodontal Regeneration and Treatments
- Anatomy and Medical Technology
- Vascular Malformations and Hemangiomas
- Reconstructive Surgery and Microvascular Techniques
- Facial Nerve Paralysis Treatment and Research
- Cancer and Skin Lesions
Tokyo Dental College
2016-2025
Oita University
2023-2025
Kanagawa Dental University
2020-2022
Kanazawa University
2019
Kanazawa University Hospital
2019
Kyoto University
2019
Nihon University
2007-2019
Fukuoka Dental College
2019
Seoul National University
2017
Seoul National University Dental Hospital
2017
The prevalence of transthyretin amyloid cardiomyopathy (ATTR-CM) in atrial fibrillation (AF) patients remains unclear. We explored the efficacy computed tomography-based myocardial extracellular volume (CT-ECV) combined with red flags for early screening concealed ATTR-CM AF undergoing catheter ablation.
According to the "hydrodynamic theory," dentinal pain or sensitivity is caused by fluid movement following application of various stimuli dentin surface. Recent convergent evidence in Vitro has shown that plasma membrane deformation, mimicking movement, activates mechanosensitive transient receptor potential (TRP)/Piezo channels odontoblasts, with Ca2+ signal eliciting release ATP from pannexin-1 (PANX-1). The released P2X3 receptor, which generates and propagates action potentials...
Mechanical stress by an orthodontic appliance induces biologically active substances. Fibroblast growth factor is a multifunctional cytokine that has various effects on fibroblast cells, and factor-2 plays important role in remodeling of the periodontal ligament. The receptor activator nuclear kappa B ligand (RANKL) protein involved osteoclastogenesis we recently reported RANKL levels were increased compression force vitro. In present study, investigated production human ligament...
Fibrotic remodeling of epicardial adipose tissue (EAT) is crucial for proinflammatory atrial myocardial fibrosis, which leads to fibrillation (AF).We tested the hypothesis that ratio central marginal adipocyte diameter in EAT represents its fibrotic remodeling. Based on a similar concept, we also whether percent (%) change fat attenuation determined using computed tomographic (CT) images can detect this remodeling.Left appendages were obtained from 76 consecutive AF patients during...
Agrobacterium sp. strain KNK712, which produced N-carbamyl-D-amino acid amidohydrolase (DCase) was isolated from soil. The bacterium had D-specific hydantoinase activity also. Both enzymes are suitable for use in the production of D-amino acids. DCase gene KNK712 cloned into Escherichia coli. DNA fragment contained one open reading frame, predicted to encode a peptide 304 amino acids, with calculated molecular weight 34,285. overexpressed under control lac promoter, and accounted 50% soluble...
Background: Oral cancer screening is important for early detection and treatment, which help improve survival rates. Biopsy the gold standard a definitive diagnosis but invasive painful, while fluorescence visualization non-invasive, convenient, real-time, examinations can be repeated using optical instruments. The purpose of this study was to clarify usefulness in oral screening. Methods: A total 502 patients, who were examined with instruments our hospitals between 2014 2019, enrolled...
<title>Abstract</title> Vital staining has long been used to delineate the horizontal margins for resection in oral squamous cell carcinoma and epithelial dysplasia (OED). In recent years, fluorescence visualization (FV), a simple non-invasive technique, identify margins. However, FV occasionally fails detect OED. The purpose of this study is investigate why lesions are not detected using evaluate their histopathology. tongues an OED rat model were examined FV, obtained images objectively...
Vital staining has long been used to delineate the horizontal margins for resection in oral squamous cell carcinoma and epithelial dysplasia (OED). In recent years, fluorescence visualization (FV), a simple non-invasive technique, identify margins. However, FV occasionally fails detect OED. The purpose of this study is investigate why lesions are not detected using evaluate their histopathology. tongues an OED rat model were examined FV, obtained images objectively evaluated by quantifying...
Several studies have shown that diabetes mellitus increases the severity of periodontitis. Conversely, periodontitis has been to an impact on diabetes, although underlying mechanisms this are unclear. The aim study was compare inflammatory response Porphyromonas gingivalis infection in normal and diabetic mice.Porphyromonas were inoculated adjacent periosteum, at a point midline skull located between ears, C57BL/6 (normal) KKAy (diabetic) mice. After induction, levels tumor necrosis...
Tokyo Dental College started oral cancer screening in cooperation with a local dental association 1992. Reveal the usefulness of Countermeasure and Opportunistic Screening Systems for Oral Cancer. The actual results countermeasure opportunistic systems are reported. public was performed each region, general clinic cooperating physician. In screening, 19,721 persons were checked from 1992 to 2018; gender ratio 1:3. close examination rate 4.45%. detection rates potentially malignant disorders...
For the production of D-amino acids, thermotolerant bacteria producing N-carbamyl-D-amino acid amidohydrolase were isolated from soil by enrichment culture at 45 degrees C with acids as sole nitrogen source. The enzyme activities and substrate specificities these strains examined resting cells reaction. One enzymes, produced Pseudomonas sp. strain KNK003A, was purified characterized, amino its N-terminal region sequenced. A DNA fragment containing gene for a thermostable then cloned into...
Relapse of teeth that have moved during orthodontic treatment is a major clinical issue with respect to the goals successful treatment. Such relapse physiologic response supporting tissues application force, and mainly attributed occlusal instability increased mechanical tension exerted by periodontal ligament (PDL). Relaxin, member insulin/relaxin family structurally related hormones, has an influence on many processes, such as collagen turnover, angiogenesis, antifibrosis. Therefore,...
Reconstructive surgery is often required for tumors of the oral and maxillofacial region, irrespective whether they are benign or malignant, area involved, tumor size. Recently, three-dimensional (3D) models increasingly used in reconstructive surgery. However, these have rarely been adapted fabrication custom-made reconstruction materials. In this report, we present a case maxillary using laboratory-engineered, mesh plate from 3D model.The patient was 56-year-old female, who had undergone...
Stem cell-based regeneration therapy offers new therapeutic options for patients with bone defects because of significant advances in stem cell research. Although marrow mesenchymal cells are the ideal material using cell, they difficult to obtain. Induced pluripotent (iPSCs) now considered an attractive tool tissue engineering. Recently, efficiency establishing iPSCs has been improved by use Sendai virus vector, and it become easier establish from several type somatic cells. In our previous...
Despite various reports on the bone healing processes of tooth extraction socket and long fracture, differences pathological changes during these remain elusive. This study aims to elucidate underlying mechanisms behind pathophysiology regeneration between femoral fractures through a comparative study. Eight-week-old male mice were used in experiments. The maxillary first molar was extracted, intramedullary nailing fracture (semistabilized repair) performed femur. Pathological injuries...
For the improvement of N-carbamyl-D-amino acid amidohydrolase (DCase), which can be used for industrial production D-amino acids, stability DCase from Agrobacterium sp. KNK712 was improved through various combinations thermostability-related mutations. The thermostable temperature (defined as on heat treatment 10 min that caused a decrease in activity 50%) enzyme had three amino H57Y, P203E, and V236A, replaced increased by about 19 degrees C. mutant DCase, designated 455M, purified its...
The purpose of this study was to investigate the treatment 190 cases ameloblastoma in our department from 1966 1994. statistical results with regard age, sex and region agreed those other investigators. Thirty-five 43 (81.4%) underwent enucleation 1960s, but sixteen 27 (59.3%) partial resection mandible 1990s. defect reconstructed iliac bone grafting since 1968, grafts a mixture blocked PCBM (particulate cancellous marrow) have been used 1975. Grafting inferior alveolar nerve great auricular...
Journal Article DNA sequence of a β-glucosidase from Ruminococcus albus Get access Kunio Ohmiya, Ohmiya School Agriculture, Nagoya UniversityChikusa, 464-01, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Masayuki Takano, Takano Shoichi Shimizu Nucleic Acids Research, Volume 18, Issue 3, 11 February 1990, Page 671, https://doi.org/10.1093/nar/18.3.671 Published: 1990 history Received: 23 December 1989