A5000186836- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Bone health and treatments
- Cancer Diagnosis and Treatment
- Anesthesia and Pain Management
- Reconstructive Surgery and Microvascular Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Oral health in cancer treatment
- Dysphagia Assessment and Management
- Ear and Head Tumors
- Ultrasound in Clinical Applications
- Oral and gingival health research
- Head and Neck Surgical Oncology
- Cardiac Valve Diseases and Treatments
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- Osteomyelitis and Bone Disorders Research
- Cleft Lip and Palate Research
- Tracheal and airway disorders
- Bone and Joint Diseases
- Hemodynamic Monitoring and Therapy
- Esophageal Cancer Research and Treatment
Tokyo Dental College
2015-2024
Tokyo Dental College Ichikawa General Hospital
2015-2024
University of Tokyo Hospital
2024
Tokyo Women's Medical University
2018-2023
Yokohama City University
2016-2022
Tokyo Women's Medical University Hospital
2020-2022
National Medical Research Center of Dentistry and Maxillofacial Surgery
2022
Tokyo Metropolitan Tama-Hokubu Medical Center
2018
Shimane University
1987-2009
Tohoku University
2002
Antiresorptive agent-related osteonecrosis of the jaw (ARONJ)/medication-related (MRONJ) include both bisphosphonate-related (BRONJ) and denosumab-related (DRONJ). The purpose this study is to radiological characteristics ARONJ/MRONJ. These imaging features may serve as one useful aid for assessing ARONJ/MRONJ.CT scans 74 Japanese patients, who were clinically diagnosed by inclusion criteria ARONJ/MRONJ, obtained between April 1, 2011 September 30, 2016, evaluated. We investigated CT...
Abstract Both metal allergy and dental focal infection have been considered as causative factors for palmoplantar pustulosis, several case reports described that the skin lesions were ameliorated after removal or control. However, limited data are available to evaluate association of these with disease severity pustulosis. This study is designed analyze clinical outcome 85 pustulosis patients control ( n = 70), tonsillectomy 6) 9). More than half (63%, 44/70) showed positive The all...
Abstract Copy number increase ( CNI ) of ACTN4 has been associated with poor prognosis and metastatic phenotypes in various human carcinomas. To identify a novel prognostic factor for salivary gland carcinoma, we investigated the copy . We evaluated DNA 58 patients carcinoma by using fluorescent situ hybridization FISH ). was recognized 14 (24.1%) carcinoma. The cases were closely histological grade P = 0.047) vascular invasion 0.033). had significantly worse than normal 0.0005 log‐rank...
Bilateral quadratus lumborum blockade (QLB) using ultrasound guidance has been introduced as an abdominal truncal block to improve postoperative analgesia and quality of recovery (QoR) after surgery, but efficacy remains controversial. The primary aim this study was evaluate the posterior QLB on QoR, secondarily pain gynaecological laparoscopic surgery (LS). This a single-centre randomized controlled trial. group patients underwent bilateral injections with 25-30 mL 0.25% levobupivacaine...
Background: Oral cancer screening is important for early detection and treatment, which help improve survival rates. Biopsy the gold standard a definitive diagnosis but invasive painful, while fluorescence visualization non-invasive, convenient, real-time, examinations can be repeated using optical instruments. The purpose of this study was to clarify usefulness in oral screening. Methods: A total 502 patients, who were examined with instruments our hospitals between 2014 2019, enrolled...
Abstract Purpose: This study examined the mechanisms of osteoclast-mediated bone invasion in a model oral squamous cell carcinoma (OSCC). C3H/HeN mice were inoculated with SCC VII cells into masseter region to establish an animal mandibular by OSCC. Experimental Design: The divided three groups: control group, given daily s.c. injections saline; group 1, 2 μg per mouse day bisphosphonate YM529; and 2, 10 YM529. After 3 weeks treatment, lesions studied micro-computed tomography....
PurposeThe aim of this study was to evaluate the effect histological subtypes head and neck adenoid cystic carcinoma (ACC) on results carbon-ion radiotherapy (CIRT).Material methodsOf 113 patients with ACC who were treated CIRT between December 2006 July 2013, 100 identified enrolled in study. at a total dose 57.6 or 64.0 Gy (RBE) administered 16 fractions. Histological grading defined as presence absence solid growth pattern.ResultsMedian follow-up 60 months. 5-Year local control (LC),...
Gorlin syndrome is a genetic disorder of autosomal dominant inheritance that predisposes the affected individual to variety disorders are attributed largely heterozygous germline patched1 (PTCH1) mutations. PTCH1 hedgehog (Hh) receptor as well repressor, mutation which leads constitutive activation Hh pathway. pathway encompasses wide cellular signaling cascades, involve several molecules; however, no associated genotype-phenotype correlations have been reported. Recently, mutations in...
Purpose: Sjögren syndrome (SS) is a chronic inflammatory autoimmune disease of the lacrimal and salivary glands. This study compared concentrations epidermal fatty-acid binding protein (E-FABP) in saliva, serum, tears SS patients with dry eye mouth, those healthy adults to investigate usefulness E-FABP as diagnostic marker for SS. Design: Prospective, observational case series. Participants: The subjects were 11 new untreated Sjogren 12 control individuals. Methods: diagnosis was accordance...
Tokyo Dental College started oral cancer screening in cooperation with a local dental association 1992. Reveal the usefulness of Countermeasure and Opportunistic Screening Systems for Oral Cancer. The actual results countermeasure opportunistic systems are reported. public was performed each region, general clinic cooperating physician. In screening, 19,721 persons were checked from 1992 to 2018; gender ratio 1:3. close examination rate 4.45%. detection rates potentially malignant disorders...
Abstract Background This study evaluated carbon‐ion radiotherapy (C‐ion RT) for oral non‐squamous cell carcinomas (non‐SCC). Methods We retrospectively obtained data from 74 patients who underwent C‐ion RT malignancies between April 1997 and March 2016. The was administered in 16 fractions at a total dose of 57.6 or 64.0 Gy (relative biological effectiveness). Results Forty‐three had salivary gland carcinomas, 29 mucosal melanoma, 2 other types pathologies. tumors were classified as T1‐T3...
Two genetic diseases, Gorlin syndrome and McCune-Albright (MAS), show completely opposite symptoms in terms of bone mineral density hedgehog (Hh) activity. In this study, we utilized human induced pluripotent stem cell (iPSC)-based models the two diseases to understand roles Hh signaling osteogenesis. syndrome-derived iPSCs showed increased osteoblastogenesis mineralization with activation upregulation a set transcription factors an osteogenic culture, compared isogenic control. MAS-specific...
Abstract Background Nivolumab is an immune checkpoint inhibitor that blocks inhibitors of T-cell activation and blunts antitumor immunity used in the treatment various cancers. However, have immune-related adverse effects on organs due to promoting activity against host tissues by blocking inhibition function. Although including hepatitis, colitis, pneumonitis, dermatitis, nephritis, endocrinopathies, hypophysitis are well recognized with established guidelines, neuromuscular rare phenomena....