A5050051838- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- DNA and Nucleic Acid Chemistry
- Endoplasmic Reticulum Stress and Disease
- Biochemical and biochemical processes
- Trypanosoma species research and implications
- Epigenetics and DNA Methylation
- Fermentation and Sensory Analysis
- Cellular transport and secretion
- Microbial Metabolism and Applications
- Research on Leishmaniasis Studies
- RNA regulation and disease
- RNA modifications and cancer
- Identification and Quantification in Food
- Ammonia Synthesis and Nitrogen Reduction
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Metalloenzymes and iron-sulfur proteins
- Biochemical Analysis and Sensing Techniques
- Retinal Development and Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Enzyme Structure and Function
- Tannin, Tannase and Anticancer Activities
- Heat shock proteins research
- Ubiquitin and proteasome pathways
Oenology Research Unit
2022-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
Université de Bordeaux
2017-2019
Bordeaux Population Health
2017-2019
Inserm
2017-2019
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2019
University of Bradford
2015-2018
University of Glasgow
2010-2013
Wellcome Centre for Molecular Parasitology
2010-2012
Wellcome Trust
2012
Metacaspases are distantly related caspase-family cysteine peptidases implicated in programmed cell death plants and lower eukaryotes. They differ significantly from caspases because they calcium-activated, arginine-specific that do not require processing or dimerization for activity. To elucidate the basis of these differences to determine impact might have on control pathways eukaryotes, previously undescribed crystal structure a metacaspase, an inactive mutant metacaspase 2 (MCA2)...
Activation of the ATF6α signaling pathway is initiated by trafficking from ER to Golgi apparatus. Its subsequent proteolysis releases a transcription factor that translocates nucleus causing downstream gene activation. How retention, trafficking, and are regulated whether additional protein partners required for its localization processing remain unresolved. Here, we show ER-resident oxidoreductase ERp18 associates with following stress plays key role in both activation ATF6α. We find...
During development, multipotent progenitor cells establish lineage-specific programmers of gene activation and silencing underlying their differentiation into specialized cell types. We show that the Polycomb component Cbx4 serves as a critical determinant maintains epithelial identity in developing epidermis by repressing nonepidermal expression programs. ablation mice results marked decrease epidermal thickness keratinocyte (KC) proliferation associated with numerous neuronal genes...
PCNA is a ring-shaped protein that encircles DNA, providing platform for the association of wide variety DNA-processing enzymes utilize sliding clamp to maintain proximity their DNA substrates. homotrimer in eukaryotes, but heterotrimer crenarchaea such as Sulfolobus solfataricus. The three proteins are SsoPCNA1 (249 residues), SsoPCNA2 (245 residues) and SsoPCNA3 (259 residues). heterotrimeric crystallizes space group P21, with unit-cell parameters = 44.8, b 78.8, c 125.6 Å, β 100.5°....
Xeroderma pigmentosum factor D (XPD) is a 5′–3′ superfamily 2 helicase and the founding member of family DNA helicases with iron–sulphur cluster domains. As component transcription II H (TFIIH), XPD involved in unwinding during nucleotide excision repair (NER). Archaeal closely related sequence to eukaryal enzyme crystal structure archaeal has provided molecular understanding mutations causing xeroderma trichothiodystrophy humans. Consistent role NER, we show that can initiate from bubble...
QSOX1 (quiescin sulfhydryl oxidase 1) efficiently catalyses the insertion of disulfide bonds into a wide range proteins. The enzyme is mechanistically well characterized, but its subcellular location and identity protein substrates remain ill-defined. function likely to involve formation in proteins entering secretory pathway or outside cell. In present study, we show that this secreted from mammalian cells despite presence transmembrane domain. We identify internal cleavage sites...
Activation of the ATF6α signaling pathway is initiated by trafficking from ER to Golgi apparatus. Its subsequent proteolysis releases a transcription factor that translocates nucleus causing downstream gene activation. How retention, trafficking, and are regulated whether additional protein partners required for its localization processing remain unresolved. Here, we show ER‐resident oxidoreductase ERp18 associates with following stress plays key role in both activation ATF6α. We find...