A5068436044- Antibiotic Resistance in Bacteria
- interferon and immune responses
- Bacterial biofilms and quorum sensing
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Salmonella and Campylobacter epidemiology
- Antimicrobial Resistance in Staphylococcus
- Inflammasome and immune disorders
Imperial College London
2022-2024
Medical Research Council
2022-2023
Abstract The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1. UBE2L3, a ubiquitin conjugating enzyme, promotes ubiquitylation and proteasomal disposal. However, actions UBE2L3 vivo its ligase partners this process are unknown. Here we report that deletion Ube2l3 mice reduces turnover macrophages, leading to excessive mature...
ABSTRACT Enterobacter cloacae is a Gram-negative nosocomial pathogen of the ESKAPE ( Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas , and spp.) priority group with increasing multi-drug resistance via acquisition plasmids. However, E. can also display forms antibiotic refractoriness, such as heteroresistance tolerance. Here, we report that displays transient to aminoglycosides, which accompanied formation small colony variants (SCVs) increased minimum inhibitor...
Abstract Enterobacter cloacae is a Gram-negative nosocomial pathogen of the ESKAPE priority group with increasing multi-drug resistance via acquisition plasmids. However, E. can also display phenotypic antimicrobial resistance, such as heteroresistance or persistence. Here we report that ATCC 13047 and six strains isolated from patients blood infections persistence to aminoglycosides. transient, accompanied formation ‘petite’ colonies increased MIC against gentamicin other aminoglycosides...
ABSTRACT The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory pathology. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1 inflammasomes. UBE2L3/UBCH7, a conserved ubiquitin conjugating enzyme, promotes ubiquitylation and proteasomal disposal. However, UBE2L3 actions vivo ligases involved this process are unknown. Here we report that deletion Ube2l3 mice markedly reduces turnover...