A5074326979- Ubiquitin and proteasome pathways
- interferon and immune responses
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
Medical Research Council
2022-2023
Imperial College London
2022-2023
Abstract The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1. UBE2L3, a ubiquitin conjugating enzyme, promotes ubiquitylation and proteasomal disposal. However, actions UBE2L3 vivo its ligase partners this process are unknown. Here we report that deletion Ube2l3 mice reduces turnover macrophages, leading to excessive mature...
ABSTRACT The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory pathology. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1 inflammasomes. UBE2L3/UBCH7, a conserved ubiquitin conjugating enzyme, promotes ubiquitylation and proteasomal disposal. However, UBE2L3 actions vivo ligases involved this process are unknown. Here we report that deletion Ube2l3 mice markedly reduces turnover...