A5027732985- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Birth, Development, and Health
- Dialysis and Renal Disease Management
- Chronic Disease Management Strategies
- HIV/AIDS drug development and treatment
- Kidney Stones and Urolithiasis Treatments
- Parvovirus B19 Infection Studies
- Global Public Health Policies and Epidemiology
- HIV-related health complications and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Polyomavirus and related diseases
- HIV Research and Treatment
- Full-Duplex Wireless Communications
- Health Promotion and Cardiovascular Prevention
- Lipid metabolism and disorders
- Pediatric Urology and Nephrology Studies
- Diet and metabolism studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
University of Cape Town
2022-2024
South African Medical Research Council
2022-2024
University of the Witwatersrand
2019
Contemporary World Health Organization data indicates that ≈39 million people are living with the human immunodeficiency virus. Of these, 24 have been reported to successfully accessed combination antiretroviral therapy. In 1996, endorsed widespread use of therapy, transforming virus infection from being a life-threatening disease chronic illness characterized by multiple comorbidities. The increased access therapy has translated (PLWH) no longer having reduced life expectancy. Although...
Uromodulin, the most abundant protein in urine, is synthesized thick ascending loop of Henle and distal convoluted tubules. Patients with chronic kidney disease (CKD) have reduced urinary uromodulin levels secondary to tubular damage. Genome wide association studies identified significant single nucleotide polymorphism (SNP) associations CKD at ( UMOD) locus. We examined concentrations SNP rs1333226 UMOD gene. The study included 71 black South Africans hypertension-attributed an eGFR ≤...
The polyomaviruses, John Cunningham (JC) and BK, infect humans, with primary infection occurring in childhood. First-degree relatives of African American individuals nondiabetic chronic kidney disease (CKD) who had 2 apolipoprotein L1 (APOL1) risk variants a lower prevalence the presence JC viruria. This study determined polyomavirus infections their effects, APOL1 alleles, on CKD.Sixty-four black South hypertension-attributed CKD an estimated glomerular filtration rate (eGFR) ≤60 ml/min per...
Variants in apolipoprotein L1 (APOL1) gene were shown to be associated with higher rates of nondiabetic kidney disease black patients compared white patients. Frequencies these variants differ substantially African populations, suggesting that their contribution might differ. We determined the frequency and association risk alleles markers South Africans hypertension-attributed chronic (CKD) first-degree relatives. Black CKD an estimated glomerular filtration rate (eGFR) ≤ 60 mL/min/1.73m2...
Uromodulin, the most abundant protein in urine, is synthesized thick ascending loop of Henle. Patients with chronic kidney disease (CKD) have reduced urinary uromodulin levels secondary to tubular damage. Genome wide association studies identified significant single nucleotide polymorphism (SNP) associations CKD at (UMOD) locus. We examined concentrations and SNP rs1333226 UMOD gene.
Abstract Background: Genome-wide association studies conducted in African Americans with non-diabetic nephropathy identified single-nucleotide polymorphism (SNP) rs16854341 podocin ( NPHS2 ) as the most significant SNP to interact apolipoprotein L1 APOL1 gene. In replication studies, SNPs , bone morphogenic protein 4 BMP4 and serologically defined colon cancer antigen 8 SDCCAG8 were found significantly . Objective: We determined of polymorphisms gene hypertension-attributed chronic kidney...
Early diagnosis of chronic kidney disease (CKD) slows progression and reduces mortality; yet screening for CKD is sparse in clinical practice. Contrary, risk factors like hypertension type 2 diabetes mellitus (T2DM) are included practice guidelines most countries. Therefore, an opportunity exists to implement as a by-product these existing programmes. To evaluate the viability screening, we used South African Diabetes Prevention Programme (SA-DPP) assess yield cases.The SA-DPP was conducted...