A5033683289- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Diabetes Treatment and Management
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Viral Infections and Immunology Research
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiac and Coronary Surgery Techniques
- Peptidase Inhibition and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Williams Syndrome Research
- Kawasaki Disease and Coronary Complications
- Vasculitis and related conditions
- Cardiovascular Effects of Exercise
- Chronic Disease Management Strategies
- Cardiac Ischemia and Reperfusion
- Protease and Inhibitor Mechanisms
- Machine Learning in Healthcare
- Radiology practices and education
- Anesthesia and Neurotoxicity Research
Sefako Makgatho Health Sciences University
2025
University of the Witwatersrand
2016-2024
Johannesburg Hospital
2016-2023
ORCID
2021
Chris Hani Baragwanath Hospital
2019
Contemporary World Health Organization data indicates that ≈39 million people are living with the human immunodeficiency virus. Of these, 24 have been reported to successfully accessed combination antiretroviral therapy. In 1996, endorsed widespread use of therapy, transforming virus infection from being a life-threatening disease chronic illness characterized by multiple comorbidities. The increased access therapy has translated (PLWH) no longer having reduced life expectancy. Although...
Abstract Background Mental health illnesses are associated with frequent hospitalisation and an increased risk of all-cause mortality. Despite the high prevalence depression in patients chronic heart failure (CHF), there is a paucity data on this subject from low middle-income countries (LMIC). The aim study was to determine depression, anxiety, stress symptoms attending dedicated CHF clinic. Methods A prospective conducted at outpatient clinic tertiary academic centre. participants...
The partnership between humans and machines can enhance clinical decisions accuracy, leading to improved patient outcomes. Despite this, the application of machine learning techniques in healthcare sector, particularly guiding heart failure management, remains unpopular. This systematic review aims identify factors restricting integration derived risk scores into practice when treating adults with acute chronic failure.Four academic research databases Google Scholar were searched original...
The age of onset and causes heart failure differ between high-income low-and-middle-income countries (LMIC). Heart patients in LMIC also experience a higher mortality rate. Innovative ways that can risk stratify this region are needed. aim study was to demonstrate the utility machine learning predicting all-cause hospitalised tertiary academic centre.Six supervised algorithms were trained predict in-hospital using data from 500 consecutive with left ventricular ejection fraction (LVEF) less...
Background. CXCR4 is a chemokine receptor that frequently overexpressed in invasive breast cancer and plays major role tumor proliferation, aggressiveness metastasis. The aim of this prospective study was to establish the value CXCR4-directed PET imaging patients with using novel CXCR4-targeted probe 68Ga-Pentixafor by comparing it 18F-FDG PET/CT (n = 40). Materials methods. In cross-sectional study, fifty-one aged 36-81 (median (Q1-Q3) 51 (42.5-63)), n 47 (92%) initially diagnosed 4 (8%)...
Background: The diagnosis and therapy of heart failure are guided mainly by a single imaging parameter, the left ventricular ejection fraction (LVEF). Recent studies have reported on value machine learning in characterising various phenotypes patients. Therefore, this study aims to use unsupervised algorithms phenotype patients into different clusters using multiple clinical parameters. Methods: Seven clustering were used cluster hospitalised with acute chronic failure. Results:...
Dilated cardiomyopathy (DCM) is a common cause of heart failure in sub-Saharan Africa (SSA). The affected individuals present with new-onset reduced ejection fraction and no identifiable primary or secondary aetiology. We aim to describe the clinical characteristics participants unknown origin.We screened 161 origin prospectively excluded causes DCM. All study were subjected laboratory biochemical testing, echocardiography, cardiovascular magnetic resonance (CMR) imaging invasive coronary...
Abstract Background The perioperative complications in patients with coronary artery disease undergoing bypass graft (CABG) surgery have been reported predominantly from developed countries, a paucity of data sub-Saharan Africa. We aim to report on the clinical characteristics and obstructive disease, managed CABG at tertiary academic hospital Johannesburg, South Methods retrospectively reviewed adult who underwent during 17-year period (January 2000 – December 2017). Data was collected...
In sub-Saharan Africa, the burden of atherosclerotic cardiovascular disease (ASCVD) is increasing. This study aimed to describe clinical characteristics patients with ST-segment elevation myocardial infarction (STEMI) and estimate in-hospital all-cause mortality rate. We conducted a cross-sectional retrospective single-centre STEMI who underwent diagnostic coronary angiography or without percutaneous intervention (PCI) between January 2015 December 2019. compared demographic parameters...
Type 2 diabetes mellitus (T2DM) patients with coronary artery disease (CAD) have an increased risk of recurrent cardiovascular events. These require optimal glucose control to prevent the progression atherosclerotic (ASCVD). Contemporary guidelines recommend HbA1c ≤7% mitigate this risk. The aim study was evaluate in T2DM angiographically proven ASCVD.We conducted a cross-sectional, retrospective on consecutive acute and chronic syndromes managed tertiary academic hospital South Africa....
Abstract Background: Mental health illnesses are associated with frequent hospitalisation and an increased risk of all-cause mortality. Despite the high prevalence depression in patients chronic heart failure (CHF), there is a paucity data on this subject from low middle-income countries (LMIC). The aim study was to determine depression, anxiety, stress symptoms attending dedicated CHF clinic. Methods: A prospective conducted at outpatient clinic tertiary academic centre. participants...
In sub-Saharan Africa, idiopathic dilated cardiomyopathy (IDCM) is a common yet poorly investigated cause of heart failure. Cardiovascular magnetic resonance (CMR) imaging the gold standard for tissue characterisation and volumetric quantification. this paper, we present CMR findings obtained from cohort patients with IDCM in Southern Africa suspected having genetic cardiomyopathy. A total 78 study participants were referred imaging. The had median left ventricular ejection fraction 24%...
Abstract Background: In high income countries depression is reported to affect at least one-fifth of patients with chronic heart failure (CHF). Mental health problems have been associated frequent rehospitalisation and an increased risk all-cause mortality. Despite the prevalence in CHF, there a paucity data on this subject from developing world. The aim study was determine depression, stress anxiety attending dedicated clinic. Methods: A prospective conducted outpatient clinic, tertiary...
Abstract Background : Pacemakers are electronic impulse generators that implanted to restore a regular heart rhythm in patients with symptomatic bradycardia. A large body of epidemiological data on permanent pacemaker implantation (PPI) originates from developed countries minimal developing regions, especially sub-Saharan Africa. This study aims describe patient demographics, clinical indications, short-term and long-term complications undergoing PPI at the Charlotte Maxeke Johannesburg...
ABSTRACT The risk of cardiovascular disease in patients with chronic inflammatory joint conditions is substantially increased compared to the general population. We present a case 27-year-old male history juvenile idiopathic arthritis (JIA) who presented denovo acutely decompensated heart failure. He had no traditional factors for atherosclerotic (ASCVD). However, during his workup dilated cardiomyopathy, he was found have extensive triple vessel on coronary artery angiography, and this...
Positron emission tomography detects patients with myocardial contractile dysfunction secondary to ischaemic heart disease who may benefit from coronary revascularisation.