Combining liquid chromatography-mass spectrometry (LC-MS)-based metabolomics experiments that were collected over a long period of time remains problematic due to systematic variability between LC-MS measurements. Until now, most normalization methods for data are model-driven, based on internal standards or intermediate quality control runs, where an external model is extrapolated the dataset interest. In first part this article, we evaluate several existing data-driven approaches...

Anaemia is a condition in which the haemoglobin concentration falls below an established cut-off value due to decrease number and size of red blood cells. The current study aimed (i) assess spatial pattern (ii) identify determinants related anaemia using third Ethiopian demographic health survey. To achieve these objectives, this took into account sampling weight clustered nature data. As result, multilevel modeling has been used statistical analysis. analysis included complete cases from...

Early initiation and exclusive breastfeeding are crucial in preventing child morbidity mortality. Despite the importance of these practices, rates timely remain suboptimal many sub-Saharan countries, including Ethiopia. This paper aimed to estimate prevalence identify determinants within first hour after birth Data from Performance Monitoring for Action Ethiopia project, a national survey conducted August 2019 September 2020, were used. The analytical sample comprises 2564 postpartum women...

Noncommunicable diseases (NCDs) are the leading cause of death worldwide. Each year, 15 million adults die from NCDs; more than 85% these premature deaths occur in low- and middle-income nations. Evidence indicates that overweight obesity main risk factors for NCDs. Although literature burden NCDs is increasing Ethiopia, no research has been conducted to demonstrate a link between overweight/obesity Therefore, aim this study examine association common while adjusting other important...

Introduction The modern contraceptive prevalence rate (mCPR) among married women has increased by nearly five-fold in Ethiopia from 8.1% 2000 to 37% 2019. Despite this increase, receipt of high quality counselling, as measured the percentage users who were told about other methods, counseled on side effects and what do event that they encountered effects, declined recent years. family planning counseling service using these three components, known Method Information Index(MII), is an index...

Malaria remains one of the most prevalent infectious diseases in tropics and subtropics, Mozambique is not an exception. To design geographically targeted effective intervention mechanisms malaria, up-to-date map that shows spatial distribution malaria needed. This study analyzed 2018 Indicator Survey using geostatistical methods to: i) explore individual, household, community-level determinants under-five children, ii) prepare a prevalence Mozambique, iii) produce prediction maps exceedence...

The World Health Organization (WHO) declared COVID-19 a pandemic on March 11, 2020 and by November 14, there were 53.3M confirmed cases 1.3M reported deaths in the world. In same period, Ethiopia 102K 1.5K deaths. Effective public health preparedness response to requires timely projections of time size peak outbreak. Currently, under COVAX facility has begun vaccinating high risk populations but due vaccine supply shortages absence an effective treatment, implementation NPIs...

<title>Abstract</title> <bold>Introduction</bold>: Anemia in Africa is a pressing public health issue with far-reaching consequences. Adolescents, especially girls, are more vulnerable to developing anemia due rapid physical growth and development, menstruation poor diets. Identifying the determinants of among adolescent girls crucial for appropriate interventions, yet evidence remains scarce. <bold>Objective</bold>: This study aims investigate magnitude Africa. <bold>Methods</bold>: Data...

Abstract In Ghana malaria is an endemic disease and the incidence of still accounts for 38.0% all outpatient attendance with most vulnerable groups being children under 5 years age. order to alleviate this problem, it essential design geographically targeted cost-effective intervention mechanisms guided by up-to-date reliable data maps that show spatial prevalence disease. The 2016 Malaria Indicator Survey (N = 2,910 under-five children) were analyzed using model-based geostatistical methods...

Abstract The World Health Organisation (WHO) declared COVID-19 a pandemic on March 11, 2020 and by November 14, there were 53.3M confirmed cases 1.3M reported deaths in the world. In same period, Ethiopia 102K 1.5K deaths. Effective public health preparedness response to requires timely projections of time size peak outbreak. Currently, absence vaccine or effective treatment, implementation NPIs (non-pharmaceutical interventions), like hand washing, wearing face coverings social distancing,...

To examine the relationship between pregnancy coercion and partner knowledge of contraceptive use. Cross-sectional Performance Monitoring for Action-Ethiopia data were collected in October-November 2019 from a nationally representative sample women ages 15-49. The analytical (n=2,469) included partnered using contraception past year. We used multinomial logistic regression to associations past-year (none, less severe, more severe) knowledge/couple discussion use (overt with couple before...

Introduction The challenge of achieving maternal and neonatal health-related goals in developing countries is significantly impacted by high fertility rates, which are partly attributed to limited access family planning the healthcare systems. most widely used indicator monitor coverage proportion women reproductive age using contraception (CPR). However, this metric does not accurately reflect true coverage, as it fails account for diverse needs age. Not all category require contraception,...

Model-based geostatistics (MBG) is a subfield of spatial statistics focused on predicting spatially continuous phenomena using data collected at discrete locations. Geostatistical models often rely the assumptions stationarity and isotropy for practical conceptual simplicity. However, an alternative perspective involves considering non-stationarity, where statistical characteristics vary across study area. While previous work has explored non-stationary processes, particularly those...

Abstract Background : One of the main challenges to achieving maternal and neonatal health-related goals in developing countries is high fertility, resulting, part, from lower family planning coverage. In Ethiopia, coverage modern contraceptive use among all women under reproductive age below 40%. To inform program efforts effectively meet needs, it essential identify factors associated with uptake contraception design geographically targeted intervention mechanisms guided by up-to-date...

In many clinical trials, in order to characterize the safety profile of a subject with given treatment, multiple measurements are taken over time. Mostly, from same not independent. Thus, cases where dependent variable is categorical, use logistic regression models assuming independence between observations appropriate. this paper, marginal and random effect that take correlation among into account were fitted extensions on existing also proposed. The applied data obtained phase-III trial...

Abstract Geostatistical models are widely used to analyze malaria data, and obtain spatial predictions at un-sampled locations based on the First Law of Geography (close things in space more similar than distant things). When environmental covariates affect not only mean underlying process under investigation but also its covariance structure, stationary for prediction questionable. In this paper, we illustrate how incorporate spatially referenced risk-factors into function model...