A5102995571- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- Tuberculosis Research and Epidemiology
- Animal testing and alternatives
- Immune Cell Function and Interaction
- interferon and immune responses
- Head and Neck Surgical Oncology
- Advanced Proteomics Techniques and Applications
- Antimicrobial Peptides and Activities
- Diagnosis and treatment of tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Veterinary Orthopedics and Neurology
- Immune responses and vaccinations
- Mycobacterium research and diagnosis
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- Long-Term Effects of COVID-19
- Veterinary Oncology Research
- T-cell and B-cell Immunology
Imperial College London
2021-2024
NIHR Imperial Biomedical Research Centre
2021-2024
St George's, University of London
2020-2022
University Hospital Southampton NHS Foundation Trust
2017
University of Southampton
2017
University of Bath
2013-2014
Knowledge of the window SARS-CoV-2 infectiousness is crucial in developing policies to curb transmission. Mathematical modelling based on scarce empirical evidence and key assumptions has driven isolation testing policy, but real-world data are needed. We aimed characterise across full course infection a community setting.The Assessment Transmission Contagiousness COVID-19 Contacts (ATACCC) study was UK prospective, longitudinal, cohort contacts newly diagnosed, PCR-confirmed index cases....
Research antibodies are used by thousands of scientists working in diverse disciplines, but it is common to hear concerns about antibody quality. This means that researchers need carefully choose the they use avoid wasting time and money. A well accepted way selecting a research identify one which has been previously, where associated data peer-reviewed results published. CiteAb searchable database ranks number times have cited. allows easily find publications accompanying citations listed,...
Introduction Sodium-glucose co-transporter inhibitors have potential glycaemic and non-glycaemic benefits in people with type 1 diabetes (T1D). However, the increased risk of diabetic ketoacidosis (DKA) limits their widespread use. We hypothesise that dapagliflozin 10 mg daily, combined use continuous ketone monitoring (CKM) education strategies to mitigate progression DKA, will demonstrate improved control without increasing DKA events. Methods analysis PARTNER is a multisite 6-month...
Abstract Blood transcriptional biomarkers of acute viral infections typically reflect type 1 interferon (IFN) signalling, but it is not known whether there are biological differences in their regulation that can be leveraged for distinct translational applications. We use high frequency sampling the SARS-CoV-2 human challenge model to show induction IFN-stimulated gene (ISG) expression with different temporal and cellular profiles. MX1 correlates a rapid transient wave ISG across all cell...
Research antibodies are used in a wide range of bioscience disciplines, yet it is common to hear dissatisfaction amongst researchers with respect their quality. Although blame often attributed the manufacturers, scientists not doing all they can help themselves. One example this reporting research antibody use. Publications routinely lack key details, including host species, code number and even company who supplied antibody. Authors also fail demonstrate that validation has taken place....
Summary Evaluation of host-response blood transcriptional signatures viral infection have so far failed to test whether these biomarkers reflect different biological processes that may be leveraged for distinct translational applications. We addressed this question in the SARS-CoV-2 human challenge model. found differential time profiles interferon (IFN) stimulated responses represented by measurement single genes. MX1 transcripts correlated with a rapid and transient wave type 1 IFN genes...
<ns4:p>Research antibodies are used in a wide range of bioscience disciplines, yet it is common to hear dissatisfaction amongst researchers with respect their quality. Although blame often attributed the manufacturers, scientists not doing all they can help themselves. One example this reporting research antibody use. Publications routinely lack key details, including host species, code number and even company who supplied antibody. Authors also fail demonstrate that validation has taken...
Abstract Vδ2+ T cells can recognize malignantly transformed as well those infected with mycobacteria. This cross-reactivity supports the idea of using mycobacteria to manipulate in cancer immunotherapy. To date, therapeutic interventions have involved expanding these or ex vivo zoledronic acid (ZA). Here, we show that mycobacterium Bacillus Calmette–Guérin (BCG) also causes T-cell expansion vitro and resulting cell populations are cytotoxic toward tumour lines. We both ZA BCG-expanded...
Release of granulysin by γδ T cells contributes to tumour cell killing. A cytolytic 9000 MW isoform kills directly, whereas a 15 000 precursor has been hypothesized cause both the maturation and migration dendritic (DC) populations. Recruiting DC is beneficial as these initiate adaptive immune responses, which contribute eradication malignancies. In this study, Vδ2+ were activated stimulation peripheral blood mononuclear with zoledronic acid or Bacillus Calmette-Guérin (BCG), isolated...
Background: The SARS-CoV-2 Delta variant is highly transmissible and spreading globally but a detailed understanding of community transmission risks in vaccinated populations lacking.Methods: Between September 2020 August 2021, we recruited 510 contacts 422 UK COVID-19 cases to cohort study. A total 7194 upper respiratory tract (URT) samples were tested from sequential daily sampling participants for up 20 days. We analysed risk by vaccination status 139 exposed the variant. compared viral...
The success of case isolation and contact tracing for the control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission depends on accuracy speed identification. We assessed whether inclusion additional symptoms alongside three canonical (CS),
The relationship between gastrointestinal tract infection, the host immune response, and clinical outcome of disease is not well understood in COVID-19. We sought to understand effect intestinal responses SARS-CoV-2 on patient outcomes including magnitude systemic antibody induction. Combining two prospective cohort studies, International Severe Acute Respiratory emerging Infections Consortium Comprehensive Clinical Characterisations Collaboration (ISARIC4C) Integrated Network for...
Abstract SARS-CoV-2 immune-escape variants have only been observed to arise in immunosuppressed COVID-19 cases, during prolonged viral shedding. Through daily longitudinal RT-qPCR, quantitative culture and sequencing, we observe for the first time evolution of transmissible harbouring mutations consistent with mild community cases within 2 weeks infection.
<h3>Objectives</h3> The wide spectrum of clinical outcomes to SARS-CoV-2 exposure suggests that early immune responses play a pivotal role.<sup>1</sup> We aim describe early, longitudinal, local (nasal mucosal lining fluid) and systemic (peripheral blood) cytokine cellular in symptomatic index case their household contacts with detailed virological phenotyping. hypothesise at symptom onset would correlate outcomes. <h3>Methods</h3> Participants from the London area are referred INSTINCT...