A5048940967- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- COVID-19 and healthcare impacts
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Nonmelanoma Skin Cancer Studies
- Heat shock proteins research
- Sarcoma Diagnosis and Treatment
- Endometriosis Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Minimally Invasive Surgical Techniques
- Advances in Oncology and Radiotherapy
- Maternal and fetal healthcare
- Immune cells in cancer
- Cancer and Skin Lesions
- Urological Disorders and Treatments
- Cancer Genomics and Diagnostics
- Diversity and Career in Medicine
- Ureteral procedures and complications
- Pelvic and Acetabular Injuries
- Hernia repair and management
- Immune Cell Function and Interaction
- Anatomy and Medical Technology
- Sperm and Testicular Function
The Royal Wolverhampton NHS Trust
2015-2024
New Cross Hospital
2023-2024
Wolverhampton Hospital
2015-2024
Royal Hospital
2024
Australia New Zealand Gynaecological Oncology Group
2019
University of Alabama at Birmingham
2019
Plymouth Hospital
2011
St James's University Hospital
2007-2009
St. James's Hospital
2009
Bradford Royal Infirmary
2005
In England, through the Genomic Medicine Service Alliances (GMSAs), a national transformation project aims to embed robust pathways deliver universal Lynch syndrome (LS) testing for patients with colorectal and endometrial cancers. Prior commencement of project, there was evidence variation low levels in eligible which is consistent other health systems; however, we believe this amenable systematic improvement responsibility delivery by local cancer teams supported regional infrastructure. A...
ABSTRACT: In order to examine the predictive value of determining sperm head shape, acrosomal size, presence vacuoles, and challenged acrosome reaction (AR) on outcome a standard in vitro fertilization (IVF) program, prospective study was conducted that included 75 couples undergoing IVF treatment. An assessment morphology performed using Hobson Sperm Tracker (Hobson Limited, Sheffield, United Kingdom). The AR before after adding pooled undiluted human follicular fluid (FF). measure an rate...
Early evidence suggests a strong impact of tumour-infiltrating lymphocytes (TILs) on both the prognosis and clinical behaviour ovarian cancer. Proven associations, however, have not yet translated to successful immunotherapies further work in field is urgently needed. We aimed analyse tumour microenvironment well-characterised cohort cancer samples. Tumour markers were selected owing their comparative underrepresentation current literature. Paraffin-embedded, formalin-fixed tissue blocks 138...
Secondary ovarian cancers, Krukenberg tumors, are a distinctive subset of metastatic tumors arising from the gastrointestinal tract (stomach, colon, and appendix), biliary system, breast, or other genital organs. These account for 5% all malignancies. Such metastases could mimic primary mucinous adenocarcinomas. Metastases urinary uncommon. Primary adenocarcinoma bladder accounts less than 1% malignancies; one third these urachal in origin. Urachal cancers rare tend to occur older men (mean...
A 37-yr-old patient previously diagnosed with human immunodeficiency virus initially presented a genital lesion which upon histologic assessment was as pseudotumor associated herpes simplex infection. The responded to initial treatment Acyclovir, however, the recurred 2 yr later and plasma cell vulvitis. We discuss clinical presentation, diagnostic work up options of such rare lesion.
Heat shock proteins (hsps) are molecular chaperones that known to play a pivotal role in regulating intracellular homeostasis. hsp27 may have diagnostic and prognostic values for different gynecological malignancies. A cross-sectional analytical study was conducted at the Department of Pathology, The University Liverpool, UK. Included were 80 cervical glandular lesions various histologic types, representing tuboendometrial metaplasia/endometriosis (n = 19), intraepithelial neoplasia 33),...
The coronavirus pandemic caused global devastation with over 2 million deaths and put unprecedented pressure on health care facilities world-wide. response to the differed globally as countries faced different challenges. Within Gynaecological oncology, a multitude of guidance was published by various organisations which demonstrated major themes. These consisted implementations aimed at reducing transmission, managing limited resources, treatment prioritisation whilst continuing urgent...
Encountering patients who present with rare conditions is daunting considering the scarcity of published recommendations. Charcot-Marie-Tooth (CMT) Disease a neuromuscular disorder. We review case strongly suspected CMT disease in patient presenting for hip surgery and assess clinical course successful treatment outcome following neuraxial anesthesia sedation. Furthermore, literature reviewed assessing effects on various physiological systems during peri-operative period.
Isthmocele is emerging as an increasingly common yet troublesome diagnosis. The spectrum of potential symptoms large, with subsequent management strategies continuing to evolve. For clinicians, having first recognized the inconsistencies in presentation, familiarity differing treatment options important. We reviewed interesting case whereby a large isthmocele secondary pseudocyst was diagnosed. diagnosis 10 years following cesarean section and three vaginal birth after section. Complex...
Ovarian cancer is a major cause of cancer-related deaths in women. Our previous study highlighted the interaction between cells and host immune response solid cancers. The present aimed to analyse proportion, density distribution T B lymphocytes within tumour surrounding stroma, their prognostic significance young women with borderline malignant ovarian surface epithelial tumours. Full clinicopathological outcome data were collected for 57 aged <50 years diagnosed January 2010 December 2015....
The coronavirus pandemic (COVID-19) has had unprecedented effects on healthcare delivery. A 34-question online survey was sent to obstetrics and gynaecology trainees within the West Midlands assess impact of training, working practices well-being. 101 responses were received from trainees. Trainees reported a significant reduction in both elective emergency surgeries as well outpatient clinics. Over one third respondents felt additional training time may be required following clinical...
Whilst the morphological (shape) and morphometric (sperm head size) attributes of ejaculated spermatozoa have been well studied, qualities testicular epididymal retrieved from males with obstructive nonobstructive azoospermia is much less documented. We wished to examine effect aetiology site retrieval on spermatozoa. This was a prospective observational study 30 consecutive successful sperm retrievals, six for 24 obstructive, which five were epididymis remainder testis. The proportion...
Heat shock proteins (hsps) are molecular chaperones that known to play a pivotal role in regulating intracellular homeostasis. hsp27 may have diagnostic and prognostic values for different gynecological malignancies. A cross-sectional analytical study was conducted at the Department of Pathology, The University Liverpool, UK. Included were 80 cervical glandular lesions various histologic types, representing tuboendometrial metaplasia/endometriosis ( n = 19), intraepithelial neoplasia 33),...
The incidence of cervical glandular intraepithelial neoplasia and adenocarcinoma is rising, our limited knowledge about these lesions presents the gynecologist with a management dilemma. Recently, pathologists have paid increasing attention to diagnosis pathogenesis cervix. Although there no uniformity in lesions, nonradical surgery appears give satisfactory results especially young women who want preserve their fertility. This review focuses on issues surrounding histologic endocervical...
Vulval extraskeletal myxoid chondrosarcoma (EMC) is a rare cause of vulval swelling, reported <10 times in the literature to date. EMC this location frequently misdiagnosed due its rarity, and patients may incur delays diagnosis treatment. We herein present management case 42‑year‑old Caucasian female patient who presented 2011 with swelling on right labium majus. The tumour was initially as Bartholin's cyst managed conservatively. ultimately diagnosed treated by radical surgical excision...