A5047075491- Rural development and sustainability
- Land Use and Ecosystem Services
- Immunotherapy and Immune Responses
- Nitric Oxide and Endothelin Effects
- Environmental Conservation and Management
- Urban Agriculture and Sustainability
- interferon and immune responses
- Organic Food and Agriculture
- Financial Crisis of the 21st Century
- Energy, Environment, Agriculture Analysis
- Urban Green Space and Health
- Forest Management and Policy
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Eicosanoids and Hypertension Pharmacology
- Agricultural Economics and Policy
- Agriculture, Land Use, Rural Development
- Urban Planning and Landscape Design
- Urban Planning and Valuation
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Sepsis Diagnosis and Treatment
- Sustainability and Climate Change Governance
- French Urban and Social Studies
VIB-UGent Center for Medical Biotechnology
2010-2024
Ghent University
2009-2023
Vlaams Instituut voor Biotechnologie
2005-2021
Instituut voor Landbouw en Visserijonderzoek
2019-2021
Research Institute of Organic Agriculture
2017
VIB-UGent Center for Inflammation Research
2014-2015
Eurogentec (Belgium)
2014
KU Leuven
2004-2009
Flemish Government
2007
Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized early excessive cytokine production the endogenous release of several toxic damaging molecules. These necessary to fight resolve cause SIRS, but often end up progressively cells tissues, leading life-threatening multiple organ dysfunction syndrome (MODS). As inflammasome-dependent cytokines interleukin-1β critically...
Food production on the urban–rural fringe is under pressure due to competing land uses. We discuss potential improve resilience for regions by enhancing food as part of multifunctional use. Through studies peri-urban in Gothenburg (Sweden), Copenhagen (Denmark) and Gent (Belgium), recent developments are analysed. Arable farming has been declining since 2000 all three areas urban expansion recreational use changes. In city plans, networks protected green spaces their importance human...
Purpose Networks and partnerships are commonly-used tools to foster knowledge sharing between actors organisations in the Agricultural Knowledge Innovation System (AKIS), but Europe policy emphasis on including users, such as farmers foresters, is relatively recent. This paper assesses user involvement a diverse set of European Union (EU)-funded non-EU (formal informal) multi-actor partnerships.Design/methodology/approach A review 200 projects other drawn from an integrated database several...
The effects of nitric oxide (NO) in the cardiovascular system are attributed part to cGMP synthesis by α1β1 isoform soluble guanylate cyclase (sGC). Because available sGC inhibitors neither enzyme- nor isoform-specific, we generated knockout mice for α1 subunit (sGCα1−/− mice) order investigate function sGCα1β1 regulation blood pressure and cardiac function. Blood was evaluated, using both non-invasive invasive haemodynamic techniques, intact gonadectomized male female sGCα1−/− wild-type...
An ideal generic cancer immunotherapy should mobilize the immune system to destroy tumor cells without harming healthy and remain active in case of recurrence. Furthermore, it preferably not rely on tumor-specific surface markers, as these are only available a limited set malignancies. Despite approval for treatment various cancers, clinical application cytokines is still impeded by their multiple toxic side effects. Type I IFN has long history cancer, but its multifaceted activity pattern...
Abstract Oxidative stress, a central mediator of cardiovascular disease, results in loss the prosthetic haem group soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC. are viable and develop hypertension. The haemodynamic effects NO abolished, but those sGC activator cinaciguat enhanced apo-sGC mice, suggesting that on smooth muscle relaxation, blood pressure regulation inhibition platelet aggregation...
Despite approval for the treatment of various malignancies, clinical application cytokines such as type I interferon (IFN) is severely impeded by their systemic toxicity. AcTakines (Activity-on-Target cytokines) are optimized immunocytokines that, when injected in mice, only reveal activity upon cell-specific impact. We here show that IFN-derived AcTaferon targeted to tumor displays strong antitumor without any associated toxicity, contrast with wild IFN. Treatment CD20-targeted CD20+...
Abstract More and more cities develop urban food strategies (UFSs) to guide their efforts practices towards sustainable systems. An emerging theme shaping these policy endeavours, especially prominent in North South America, concerns the enhancement of social justice within To operationalise this a European governance context we adopt Nancy Fraser’s three-dimensional theory justice: economic redistribution, cultural recognition political representation. In paper, discuss findings an...
• The OIS concept can be used to analyse multi-actor co-innovation partnerships.• Co-innovation partnerships in agriculture and forestry occur many forms.• Often based on existing networks, they mobilise complementary forms of knowledge.• 'Outreach' practices foster dialogue with a 'larger periphery' are commonly used.• 'enabling environment' affects the performance partnership.
The key European Union (EU) policy instrument in support of innovation agriculture, forestry and related sectors is the Innovation Partnership for Agricultural Productivity Sustainability. It applies 'interactive model' which brings together actors with complementary types knowledge. This implemented inter alia through multi-actor projects funded via Horizon 2020 (H2020) Research (R&I) programme. Although H2020 account a substantial part EU project funding sector R&I, systematic comparative...
Abstract Type I interferon (IFN) is a potent antitumoral drug, with an important history in the treatment of hematologic malignancies. However, its pleiotropic nature leads to severe dose-limiting toxicities that blunt therapeutic potential. To achieve selective targeting specific immune or tumor cells, AcTakines (Activity-on-Target Cytokines), i.e., immunocytokines utilizing attenuated cytokines, and clinically optimized A-Kines™ were developed. In syngeneic murine models, CD20-targeted...