A5108031768- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Lysosomal Storage Disorders Research
- Multiple Myeloma Research and Treatments
- Cellular transport and secretion
- Neuropeptides and Animal Physiology
- Synthesis and Biological Evaluation
- Axon Guidance and Neuronal Signaling
- Vascular Tumors and Angiosarcomas
- Hematopoietic Stem Cell Transplantation
- Lymphatic System and Diseases
- Intensive Care Unit Cognitive Disorders
- Viral Infectious Diseases and Gene Expression in Insects
- PI3K/AKT/mTOR signaling in cancer
- Trypanosoma species research and implications
- Cell death mechanisms and regulation
- Photoacoustic and Ultrasonic Imaging
- RNA Interference and Gene Delivery
- Animal Virus Infections Studies
- Kruppel-like factors research
- Enzyme Catalysis and Immobilization
- Pharmacogenetics and Drug Metabolism
- Genetic and Kidney Cyst Diseases
- Plant Virus Research Studies
- Hippo pathway signaling and YAP/TAZ
Neuroscience Institute
2009-2020
National Research Council
2009-2020
University of Milan
1983-2014
Institute of Chemistry of Molecular Recognition
2007
Institut Pasteur de Lille
1983
Inserm
1983
The anti-lymphoma activity and mechanism(s) of action the multikinase inhibitor sorafenib were investigated using a panel lymphoma cell lines, including SU-DHL-4V, Granta-519, HD-MyZ, KMS-11 lines. In vitro, significantly decreased proliferation phosphorylation levels MAPK PI3K/Akt pathways while increased apoptotic death. vivo, treatment resulted in cytostatic rather than cytotoxic effect on tumor growth associated with limited inhibition volumes. However, induced an average 50% reduction...
POF1B is a candidate gene for premature ovarian failure (POF); it mainly expressed in polarised epithelial tissues, but its function these tissues and the relationship with disorder are unknown. Here we show colocalisation of markers both adherens tight junctions human jejunum. The junction localisation was maintained by stably MDCK cell line, whereas lost R329Q variant associated POF. Localisation apico-basal polarity ultrastructure were cells expressing mutant. However, assembly altered,...
DEPARTMENTS: A Closing Word: Innovation in Clinical Practice: Preliminary Study on Delirium Assessment Intensive Care Unit Using an Application for Smartphone
Quantitative characterization of the in vivo effects vascular-targeted therapies on tumor vessels is hampered by absence useful 3D vascular network descriptors aside from microvessel density. In this study, we extended quantification planar vessel distribution to analysis volumes studying antiangiogenic (sorafenib and sunitinib) or antivascular (combretastatin A4 phosphate) treatments quantity spatial distributions thin microvessels. These observations were restricted perinecrotic areas...
The α3β4 subtype is the predominant neuronal nicotinic acetylcholine receptor present in sensory and autonomic ganglia a subpopulation of brain neurons. This can form pentameric receptors with either 2 or 3 β4 subunits that have different pharmacologic functional properties. To further investigate role fifth subunit, we coexpressed dimeric construct coding for single polypeptide containing α3 subunit sequences, monomeric subunits. With this strategy, which allowed formation populations...
We performed a three-dimensional (3D) analysis of the microvascular network cerebral cortex twitcher mice (an authentic model Krabbe disease) using restricted set indexes that are able to describe arrangement tree in CD31-stained sections. obtained near-linear graphical "fingerprint" microangioarchitecture wild-type and animals describes amounts, spatial dispersion, relationships adjacent classes caliber-filtered microvessels. observed significant alterations mice, whereas no occur renal...
Blood vessel micro-angioarchitecture plays a pivotal role in tumor progression, metastatic dissemination and response to therapy. Thus, methods able quantify microvascular trees their anomalies may allow better comprehension of the neovascularization process evaluation vascular-targeted therapies cancer. To this aim, development restricted set indexes describe arrangement tree is eagerly required. We addressed goal through 3D analysis functional network sulfo-biotin-stained human multiple...
Krabbe disease (KD) is an autosomal recessive sphingolipidosis caused by the deficiency of lysosomal hydrolase β-galactosylceramidase (GALC). Oligodendroglia degeneration and demyelination nervous system lead to neurological dysfunctions which are usually lethal two years age. At present, only clinical treatment with any proven efficacy hematopoietic stem-cell transplantation, more effective when administered in neonatal period presymptomatic recipients. Bone marrow (BM) sinusoidal...